Fanconi syndrome with hepatorenal karyomegaly in a young Sphynx cat
Case summary A 3-year-old male neutered Sphynx cat was referred for history of chronically increased liver enzymes and lower urinary tract signs that were first reported when the cat was 5 months old. Urine metabolic profile revealed increased amino aciduria and glucosuria despite normoglycemia, sug...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-10-01
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| Series: | Journal of Feline Medicine and Surgery Open Reports |
| Online Access: | https://doi.org/10.1177/20551169231190611 |
| _version_ | 1797663858784993280 |
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| author | Petra Cˇerná Michaela M Botts Maggie Williams Tawfik A Aboellail Sarah Shropshire |
| author_facet | Petra Cˇerná Michaela M Botts Maggie Williams Tawfik A Aboellail Sarah Shropshire |
| author_sort | Petra Cˇerná |
| collection | DOAJ |
| description | Case summary A 3-year-old male neutered Sphynx cat was referred for history of chronically increased liver enzymes and lower urinary tract signs that were first reported when the cat was 5 months old. Urine metabolic profile revealed increased amino aciduria and glucosuria despite normoglycemia, suggesting Fanconi syndrome. Urine sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed a banding pattern suggestive of primary tubular damage. Serial blood work showed non-regenerative normocytic normochromic anemia, persistently elevated liver enzymes, worsening azotemia and progressive hyperchloremic metabolic acidosis. Ultrasound revealed irregular kidneys and bilaterally hyperechoic cortices and medullae with a loss of normal corticomedullary distinction. Laparoscopic kidney biopsy revealed a moderate-to-severe chronic interstitial fibrosis with chronic lymphoplasmacytic inflammation, tubular degeneration and atrophy, mild glomerulosclerosis and mild large vascular amyloidosis. Tubular epithelial cell karyomegaly was multifocally evident throughout the kidney. The liver had moderate diffuse zone 1 hepatocellular atrophy, periportal fibrosis, biliary hyperplasia, mild perisinusoidal amyloidosis and hepatocyte karyomegaly in zones 2 and 3. The patient continued to decline and developed polyuria, polydipsia, lethargy and hyporexia irrespective of rigorous management, which failed to curtail the progressive anemia and azotemia. The patient was euthanized 8 months from the onset of clinical signs. Relevance and novel information Fanconi syndrome in cats is a rare condition, with most reports occurring secondary to chlorambucil treatment. This is the first known case of Fanconi syndrome occurring with concurrent hepatorenal epithelial karyomegaly in a young Sphynx cat. |
| first_indexed | 2024-03-11T19:20:52Z |
| format | Article |
| id | doaj.art-39f5ea3f0fbe4a94bc319217b671b152 |
| institution | Directory Open Access Journal |
| issn | 2055-1169 |
| language | English |
| last_indexed | 2024-03-11T19:20:52Z |
| publishDate | 2023-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Feline Medicine and Surgery Open Reports |
| spelling | doaj.art-39f5ea3f0fbe4a94bc319217b671b1522023-10-07T09:03:45ZengSAGE PublishingJournal of Feline Medicine and Surgery Open Reports2055-11692023-10-01910.1177/20551169231190611Fanconi syndrome with hepatorenal karyomegaly in a young Sphynx catPetra Cˇerná0Michaela M Botts1Maggie Williams2Tawfik A Aboellail3Sarah Shropshire4Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USADepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USAFaculty of Veterinary Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USADepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USACase summary A 3-year-old male neutered Sphynx cat was referred for history of chronically increased liver enzymes and lower urinary tract signs that were first reported when the cat was 5 months old. Urine metabolic profile revealed increased amino aciduria and glucosuria despite normoglycemia, suggesting Fanconi syndrome. Urine sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed a banding pattern suggestive of primary tubular damage. Serial blood work showed non-regenerative normocytic normochromic anemia, persistently elevated liver enzymes, worsening azotemia and progressive hyperchloremic metabolic acidosis. Ultrasound revealed irregular kidneys and bilaterally hyperechoic cortices and medullae with a loss of normal corticomedullary distinction. Laparoscopic kidney biopsy revealed a moderate-to-severe chronic interstitial fibrosis with chronic lymphoplasmacytic inflammation, tubular degeneration and atrophy, mild glomerulosclerosis and mild large vascular amyloidosis. Tubular epithelial cell karyomegaly was multifocally evident throughout the kidney. The liver had moderate diffuse zone 1 hepatocellular atrophy, periportal fibrosis, biliary hyperplasia, mild perisinusoidal amyloidosis and hepatocyte karyomegaly in zones 2 and 3. The patient continued to decline and developed polyuria, polydipsia, lethargy and hyporexia irrespective of rigorous management, which failed to curtail the progressive anemia and azotemia. The patient was euthanized 8 months from the onset of clinical signs. Relevance and novel information Fanconi syndrome in cats is a rare condition, with most reports occurring secondary to chlorambucil treatment. This is the first known case of Fanconi syndrome occurring with concurrent hepatorenal epithelial karyomegaly in a young Sphynx cat.https://doi.org/10.1177/20551169231190611 |
| spellingShingle | Petra Cˇerná Michaela M Botts Maggie Williams Tawfik A Aboellail Sarah Shropshire Fanconi syndrome with hepatorenal karyomegaly in a young Sphynx cat Journal of Feline Medicine and Surgery Open Reports |
| title | Fanconi syndrome with hepatorenal karyomegaly in a young Sphynx cat |
| title_full | Fanconi syndrome with hepatorenal karyomegaly in a young Sphynx cat |
| title_fullStr | Fanconi syndrome with hepatorenal karyomegaly in a young Sphynx cat |
| title_full_unstemmed | Fanconi syndrome with hepatorenal karyomegaly in a young Sphynx cat |
| title_short | Fanconi syndrome with hepatorenal karyomegaly in a young Sphynx cat |
| title_sort | fanconi syndrome with hepatorenal karyomegaly in a young sphynx cat |
| url | https://doi.org/10.1177/20551169231190611 |
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