Association of blood group a with colorectal cancer prevalence in Croatian population
Purpose: The aim of our study was to investigate the association of ABO phenotypes and genotypes with colorectal cancer prevalence in Croatian population. Methods: Study included 80 patients (51 men) with colorectal cancer and 303 healthy volunteer blood donors (180 men) in the control group. Using...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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University Hospital for Tumors
2023-01-01
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| Series: | Libri Oncologici |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/454009 |
| _version_ | 1827281523330514944 |
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| author | Matea Vinković Nikolina Parašilovac Pavica Šonjić Jasna Bingulac-Popović Karmela Barišić Irena Jukić |
| author_facet | Matea Vinković Nikolina Parašilovac Pavica Šonjić Jasna Bingulac-Popović Karmela Barišić Irena Jukić |
| author_sort | Matea Vinković |
| collection | DOAJ |
| description | Purpose: The aim of our study was to investigate the association of ABO phenotypes and genotypes with colorectal cancer prevalence in Croatian population.
Methods: Study included 80 patients (51 men) with colorectal cancer and 303 healthy volunteer blood donors (180 men) in the control group. Using the PCR-SSP method, genotyping was performed on 5 main alleles (O1, O2, A1, A2, B), resulting in 15 ABO genotypes.
Results: There was no difference in the prevalence of colorectal cancer between men and women. There was no difference in a specific blood group phenotype between patients and healthy controls. However, there was a statistically significant higher odds ratio for individuals to carry blood group A than O in patients with colorectal cancer. There was no significant higher odds ratio for non-O genotypes compared to all genotypes constituting O blood group in patients with colorectal cancer.
Conclusion: Our study has shown that there are higher odds for blood group A in colorectal patients than O when compared to healthy controls, suggesting blood group A could be a potential risk factor for colorectal cancer. This is accordant with some previously published studies. Further studies with larger group of patients and controls are needed to confirm this observation. |
| first_indexed | 2024-04-24T09:02:43Z |
| format | Article |
| id | doaj.art-39f73cd94ab24c08993e0e5d2c06b24c |
| institution | Directory Open Access Journal |
| issn | 0300-8142 2584-3826 |
| language | English |
| last_indexed | 2024-04-24T09:02:43Z |
| publishDate | 2023-01-01 |
| publisher | University Hospital for Tumors |
| record_format | Article |
| series | Libri Oncologici |
| spelling | doaj.art-39f73cd94ab24c08993e0e5d2c06b24c2024-04-15T19:21:47ZengUniversity Hospital for TumorsLibri Oncologici0300-81422584-38262023-01-01512-3657010.20471/LO.2023.51.02-03.10Association of blood group a with colorectal cancer prevalence in Croatian populationMatea Vinković0Nikolina Parašilovac1Pavica Šonjić2Jasna Bingulac-Popović3Karmela Barišić4Irena Jukić5Research and Development Department, Croatian Institute of Transfusion Medicine (CITM), Zagreb, Croatia and Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, CroatiaDepartment of Medical Biochemistry and Laboratory Medicine, Merkur University Hospital, Zagreb, CroatiaClinical Department for Laboratory Diagnostics, Clinical Hospital Center Rijeka, Rijeka, CroatiaMolecular Diagnostics Department, Croatian Institute of Transfusion Medicine (CITM), Zagreb, CroatiaFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, CroatiaMedical Department, Croatian Institute of Transfusion Medicine (CITM), Zagreb, CroatiaPurpose: The aim of our study was to investigate the association of ABO phenotypes and genotypes with colorectal cancer prevalence in Croatian population. Methods: Study included 80 patients (51 men) with colorectal cancer and 303 healthy volunteer blood donors (180 men) in the control group. Using the PCR-SSP method, genotyping was performed on 5 main alleles (O1, O2, A1, A2, B), resulting in 15 ABO genotypes. Results: There was no difference in the prevalence of colorectal cancer between men and women. There was no difference in a specific blood group phenotype between patients and healthy controls. However, there was a statistically significant higher odds ratio for individuals to carry blood group A than O in patients with colorectal cancer. There was no significant higher odds ratio for non-O genotypes compared to all genotypes constituting O blood group in patients with colorectal cancer. Conclusion: Our study has shown that there are higher odds for blood group A in colorectal patients than O when compared to healthy controls, suggesting blood group A could be a potential risk factor for colorectal cancer. This is accordant with some previously published studies. Further studies with larger group of patients and controls are needed to confirm this observation.https://hrcak.srce.hr/file/454009colorectal neoplasmsABO blood-group systemblood group antigens |
| spellingShingle | Matea Vinković Nikolina Parašilovac Pavica Šonjić Jasna Bingulac-Popović Karmela Barišić Irena Jukić Association of blood group a with colorectal cancer prevalence in Croatian population Libri Oncologici colorectal neoplasms ABO blood-group system blood group antigens |
| title | Association of blood group a with colorectal cancer prevalence in Croatian population |
| title_full | Association of blood group a with colorectal cancer prevalence in Croatian population |
| title_fullStr | Association of blood group a with colorectal cancer prevalence in Croatian population |
| title_full_unstemmed | Association of blood group a with colorectal cancer prevalence in Croatian population |
| title_short | Association of blood group a with colorectal cancer prevalence in Croatian population |
| title_sort | association of blood group a with colorectal cancer prevalence in croatian population |
| topic | colorectal neoplasms ABO blood-group system blood group antigens |
| url | https://hrcak.srce.hr/file/454009 |
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