Nerve Growth Factor and the Role of Inflammation in Tumor Development
Nerve growth factor (NGF) plays a dual role both in inflammatory states and cancer, acting both as a pro-inflammatory and oncogenic factor and as an anti-inflammatory and pro-apoptotic mediator in a context-dependent way based on the signaling networks and its interaction with diverse cellular compo...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/46/2/62 |
| _version_ | 1827343854074855424 |
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| author | Giampiero Ferraguti Sergio Terracina Luigi Tarani Francesca Fanfarillo Sara Allushi Brunella Caronti Paola Tirassa Antonella Polimeni Marco Lucarelli Luca Cavalcanti Antonio Greco Marco Fiore |
| author_facet | Giampiero Ferraguti Sergio Terracina Luigi Tarani Francesca Fanfarillo Sara Allushi Brunella Caronti Paola Tirassa Antonella Polimeni Marco Lucarelli Luca Cavalcanti Antonio Greco Marco Fiore |
| author_sort | Giampiero Ferraguti |
| collection | DOAJ |
| description | Nerve growth factor (NGF) plays a dual role both in inflammatory states and cancer, acting both as a pro-inflammatory and oncogenic factor and as an anti-inflammatory and pro-apoptotic mediator in a context-dependent way based on the signaling networks and its interaction with diverse cellular components within the microenvironment. This report aims to provide a summary and subsequent review of the literature on the role of NGF in regulating the inflammatory microenvironment and tumor cell growth, survival, and death. The role of NGF in inflammation and tumorigenesis as a component of the inflammatory system, its interaction with the various components of the respective microenvironments, its ability to cause epigenetic changes, and its role in the treatment of cancer have been highlighted in this paper. |
| first_indexed | 2024-03-07T22:37:29Z |
| format | Article |
| id | doaj.art-39f7767e01fd4f9eab43dc2d8408bd22 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-07T22:37:29Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-39f7767e01fd4f9eab43dc2d8408bd222024-02-23T15:12:33ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-01-0146296598910.3390/cimb46020062Nerve Growth Factor and the Role of Inflammation in Tumor DevelopmentGiampiero Ferraguti0Sergio Terracina1Luigi Tarani2Francesca Fanfarillo3Sara Allushi4Brunella Caronti5Paola Tirassa6Antonella Polimeni7Marco Lucarelli8Luca Cavalcanti9Antonio Greco10Marco Fiore11Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Human Neurosciences, Sapienza University Hospital of Rome, 00185 Rome, ItalyInstitute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Odontostomatological and Maxillofacial Sciences, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Sensory Organs, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Sensory Organs, Sapienza University of Rome, 00185 Rome, ItalyInstitute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, ItalyNerve growth factor (NGF) plays a dual role both in inflammatory states and cancer, acting both as a pro-inflammatory and oncogenic factor and as an anti-inflammatory and pro-apoptotic mediator in a context-dependent way based on the signaling networks and its interaction with diverse cellular components within the microenvironment. This report aims to provide a summary and subsequent review of the literature on the role of NGF in regulating the inflammatory microenvironment and tumor cell growth, survival, and death. The role of NGF in inflammation and tumorigenesis as a component of the inflammatory system, its interaction with the various components of the respective microenvironments, its ability to cause epigenetic changes, and its role in the treatment of cancer have been highlighted in this paper.https://www.mdpi.com/1467-3045/46/2/62apoptosiscancer stem cellsmetastasisepigeneticinflammationmicroenvironment |
| spellingShingle | Giampiero Ferraguti Sergio Terracina Luigi Tarani Francesca Fanfarillo Sara Allushi Brunella Caronti Paola Tirassa Antonella Polimeni Marco Lucarelli Luca Cavalcanti Antonio Greco Marco Fiore Nerve Growth Factor and the Role of Inflammation in Tumor Development Current Issues in Molecular Biology apoptosis cancer stem cells metastasis epigenetic inflammation microenvironment |
| title | Nerve Growth Factor and the Role of Inflammation in Tumor Development |
| title_full | Nerve Growth Factor and the Role of Inflammation in Tumor Development |
| title_fullStr | Nerve Growth Factor and the Role of Inflammation in Tumor Development |
| title_full_unstemmed | Nerve Growth Factor and the Role of Inflammation in Tumor Development |
| title_short | Nerve Growth Factor and the Role of Inflammation in Tumor Development |
| title_sort | nerve growth factor and the role of inflammation in tumor development |
| topic | apoptosis cancer stem cells metastasis epigenetic inflammation microenvironment |
| url | https://www.mdpi.com/1467-3045/46/2/62 |
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