Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season
Influenza vaccination is the most effective way of preventing influenza infections but its coverage is extremely low in China. Poor influenza vaccine effectiveness (VE) was reported in the 2014/15 season in some Northern Hemisphere countries with a predominance of H3N2 viruses belonging to the 3C.2a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-10-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1359364 |
| _version_ | 1797677535401607168 |
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| author | Chunna Ma Yang Pan Li Zhang Yi Zhang Shuangsheng Wu Ying Sun Wei Duan Man Zhang Quanyi Wang Peng Yang |
| author_facet | Chunna Ma Yang Pan Li Zhang Yi Zhang Shuangsheng Wu Ying Sun Wei Duan Man Zhang Quanyi Wang Peng Yang |
| author_sort | Chunna Ma |
| collection | DOAJ |
| description | Influenza vaccination is the most effective way of preventing influenza infections but its coverage is extremely low in China. Poor influenza vaccine effectiveness (VE) was reported in the 2014/15 season in some Northern Hemisphere countries with a predominance of H3N2 viruses belonging to the 3C.2a clade. However, there is limited information regarding the preventive effect of influenza vaccination for the same season in China, in which H3N2 viruses belonging to the 3C.3a clade predominated. Through influenza virological surveillance in Beijing, China during the 2014/15 season, we estimated the influenza VE against medically attended influenza-like illness (ILI) associated with laboratory-confirmed influenza virus infection using a test-negative design, and the effect of prior vaccination on current vaccination was examined. In total, 9297 patients with ILI were enrolled in this study. Among them, 3434 (36.9%) tested positive for influenza viruses: 2167 (63.1%) for A(H3N2), 1261 (36.7%) for influenza B, and 3 (0.1%) for A(H1N1)pdm09. The adjusted VE was estimated as −25% (95% CI: −70%, 8%) against A(H3N2) and −8% (95% CI: −50%, 23%) against B, with an overall VE of −18% (95% CI: −49%, 6%). The overall VE estimate for patients who received 2014/15 vaccination only was −12% (−57%, 20%), while VE for patients who received both 2013/14 and 2014/15 vaccinations was −27% (−72%, 7%). There was no evidence that the influenza vaccine protected vaccinees against medically attended influenza in Beijing, China during the 2014/15 season. |
| first_indexed | 2024-03-11T22:46:35Z |
| format | Article |
| id | doaj.art-39fb527d7fb64336876db79bfdcf2ab1 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:46:35Z |
| publishDate | 2017-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-39fb527d7fb64336876db79bfdcf2ab12023-09-22T08:17:51ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2017-10-0113102379238410.1080/21645515.2017.13593641359364Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 seasonChunna Ma0Yang Pan1Li Zhang2Yi Zhang3Shuangsheng Wu4Ying Sun5Wei Duan6Man Zhang7Quanyi Wang8Peng Yang9Beijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlInfluenza vaccination is the most effective way of preventing influenza infections but its coverage is extremely low in China. Poor influenza vaccine effectiveness (VE) was reported in the 2014/15 season in some Northern Hemisphere countries with a predominance of H3N2 viruses belonging to the 3C.2a clade. However, there is limited information regarding the preventive effect of influenza vaccination for the same season in China, in which H3N2 viruses belonging to the 3C.3a clade predominated. Through influenza virological surveillance in Beijing, China during the 2014/15 season, we estimated the influenza VE against medically attended influenza-like illness (ILI) associated with laboratory-confirmed influenza virus infection using a test-negative design, and the effect of prior vaccination on current vaccination was examined. In total, 9297 patients with ILI were enrolled in this study. Among them, 3434 (36.9%) tested positive for influenza viruses: 2167 (63.1%) for A(H3N2), 1261 (36.7%) for influenza B, and 3 (0.1%) for A(H1N1)pdm09. The adjusted VE was estimated as −25% (95% CI: −70%, 8%) against A(H3N2) and −8% (95% CI: −50%, 23%) against B, with an overall VE of −18% (95% CI: −49%, 6%). The overall VE estimate for patients who received 2014/15 vaccination only was −12% (−57%, 20%), while VE for patients who received both 2013/14 and 2014/15 vaccinations was −27% (−72%, 7%). There was no evidence that the influenza vaccine protected vaccinees against medically attended influenza in Beijing, China during the 2014/15 season.http://dx.doi.org/10.1080/21645515.2017.1359364chinainfluenzainfluenza-like illnesstest-negative designvaccine effectiveness |
| spellingShingle | Chunna Ma Yang Pan Li Zhang Yi Zhang Shuangsheng Wu Ying Sun Wei Duan Man Zhang Quanyi Wang Peng Yang Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season Human Vaccines & Immunotherapeutics china influenza influenza-like illness test-negative design vaccine effectiveness |
| title | Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season |
| title_full | Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season |
| title_fullStr | Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season |
| title_full_unstemmed | Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season |
| title_short | Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season |
| title_sort | influenza vaccine effectiveness against medically attended influenza illness in beijing china 2014 15 season |
| topic | china influenza influenza-like illness test-negative design vaccine effectiveness |
| url | http://dx.doi.org/10.1080/21645515.2017.1359364 |
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