Current Understanding of the Role of Senescent Melanocytes in Skin Ageing
Melanocytes reside within the basal epidermis of human skin, and function to protect the skin from ultraviolet light through the production of melanin. Prolonged exposure of the skin to UV light can induce irreparable DNA damage and drive cells into senescence, a sustained cell cycle arrest that pre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/12/3111 |
| _version_ | 1797461340670918656 |
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| author | Bethany K. Hughes Cleo L. Bishop |
| author_facet | Bethany K. Hughes Cleo L. Bishop |
| author_sort | Bethany K. Hughes |
| collection | DOAJ |
| description | Melanocytes reside within the basal epidermis of human skin, and function to protect the skin from ultraviolet light through the production of melanin. Prolonged exposure of the skin to UV light can induce irreparable DNA damage and drive cells into senescence, a sustained cell cycle arrest that prevents the propagation of this damage. Senescent cells can also be detrimental and contribute to skin ageing phenotypes through their senescence-associated secretory phenotype. Senescent cells can act in both an autocrine and paracrine manner to produce widespread tissue inflammation and skin ageing. Recently, melanocytes have been identified as the main senescent cell population within the epidermis and have been linked to a variety of skin ageing phenotypes, such as epidermal thinning and the presence of wrinkles. However, the literature surrounding melanocyte senescence is limited and tends to focus on the role of senescence in the prevention of melanoma. Therefore, this review aims to explore the current understanding of the contribution of senescent melanocytes to human skin ageing. |
| first_indexed | 2024-03-09T17:18:02Z |
| format | Article |
| id | doaj.art-39fbf576240a48b4b19ab557eaf3e606 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:18:02Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-39fbf576240a48b4b19ab557eaf3e6062023-11-24T13:27:01ZengMDPI AGBiomedicines2227-90592022-12-011012311110.3390/biomedicines10123111Current Understanding of the Role of Senescent Melanocytes in Skin AgeingBethany K. Hughes0Cleo L. Bishop1Barts and the London Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, 4, Newark Street, London E1 2AT, UKBarts and the London Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, 4, Newark Street, London E1 2AT, UKMelanocytes reside within the basal epidermis of human skin, and function to protect the skin from ultraviolet light through the production of melanin. Prolonged exposure of the skin to UV light can induce irreparable DNA damage and drive cells into senescence, a sustained cell cycle arrest that prevents the propagation of this damage. Senescent cells can also be detrimental and contribute to skin ageing phenotypes through their senescence-associated secretory phenotype. Senescent cells can act in both an autocrine and paracrine manner to produce widespread tissue inflammation and skin ageing. Recently, melanocytes have been identified as the main senescent cell population within the epidermis and have been linked to a variety of skin ageing phenotypes, such as epidermal thinning and the presence of wrinkles. However, the literature surrounding melanocyte senescence is limited and tends to focus on the role of senescence in the prevention of melanoma. Therefore, this review aims to explore the current understanding of the contribution of senescent melanocytes to human skin ageing.https://www.mdpi.com/2227-9059/10/12/3111melanocytesenescenceskinageingUV |
| spellingShingle | Bethany K. Hughes Cleo L. Bishop Current Understanding of the Role of Senescent Melanocytes in Skin Ageing Biomedicines melanocyte senescence skin ageing UV |
| title | Current Understanding of the Role of Senescent Melanocytes in Skin Ageing |
| title_full | Current Understanding of the Role of Senescent Melanocytes in Skin Ageing |
| title_fullStr | Current Understanding of the Role of Senescent Melanocytes in Skin Ageing |
| title_full_unstemmed | Current Understanding of the Role of Senescent Melanocytes in Skin Ageing |
| title_short | Current Understanding of the Role of Senescent Melanocytes in Skin Ageing |
| title_sort | current understanding of the role of senescent melanocytes in skin ageing |
| topic | melanocyte senescence skin ageing UV |
| url | https://www.mdpi.com/2227-9059/10/12/3111 |
| work_keys_str_mv | AT bethanykhughes currentunderstandingoftheroleofsenescentmelanocytesinskinageing AT cleolbishop currentunderstandingoftheroleofsenescentmelanocytesinskinageing |