Evaluation of the clinical significance of serum pentraxin-3 levels in patients with polycystic ovary syndrome
Background: Polycystic ovary syndrome (PCOS) is commonly associated with insulin resistance (IR), hyperinsulinemia, and dyslipidemia, which play a role in the development of endothelial dysfunction and promote the early onset of cardiovascular diseases. The aim of this study was to evaluate the clin...
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| Format: | Article |
| Language: | English |
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IMR Press
2022-02-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/49/2/10.31083/j.ceog4902038 |
| _version_ | 1818232064160301056 |
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| author | Fatih Yeşil Köksal Deveci Pervin Karli |
| author_facet | Fatih Yeşil Köksal Deveci Pervin Karli |
| author_sort | Fatih Yeşil |
| collection | DOAJ |
| description | Background: Polycystic ovary syndrome (PCOS) is commonly associated with insulin resistance (IR), hyperinsulinemia, and dyslipidemia, which play a role in the development of endothelial dysfunction and promote the early onset of cardiovascular diseases. The aim of this study was to evaluate the clinical importance of pentraxin-3 levels in PCOS patients. Methods: Forty-five female patients diagnosed with PCOS according to the 2003 Rotterdam criteria and 42 healthy women were included in the study. All women studied were tested within 3 and 5 days of their menstrual cycle. Ultrasonographic evaluation of each patient was first conducted using the suprapubic method. Serum PTX-3, endothelin 1 (ET-1), vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and nitric oxide levels were measured using the enzyme-linked immunosorbent assay method. Results: Pentraxine-3 (PTX-3) levels in the patient group were significantly lower than those in the control group (p < 0.05). PTX-3 levels in the group with hirsutism were significantly higher than those in the nonhirsutism group (p < 0.05). Homeostatic model assessment for IR (HOMA-IR) levels in the patient group were significantly higher than those in the control group (p < 0.01). A weak negative correlation was found between PTX-3 and HbA1c levels. The accuracy rate of the PTX-3 test in distinguishing patients and nonpatients was moderate with a 0.634 area-under-the-curve value. Conclusions: During the follow-up of patients with PCOS, a decrease in serum PTX-3 levels associated with hirsutism and IR may be observed. |
| first_indexed | 2024-12-12T11:00:20Z |
| format | Article |
| id | doaj.art-39fced1f14c24a08a6bd8fa1953c856c |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-12-12T11:00:20Z |
| publishDate | 2022-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-39fced1f14c24a08a6bd8fa1953c856c2022-12-22T00:26:32ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-02-014923810.31083/j.ceog4902038S0390-6663(22)01687-6Evaluation of the clinical significance of serum pentraxin-3 levels in patients with polycystic ovary syndromeFatih Yeşil0Köksal Deveci1Pervin Karli2Department of Biochemistry, Gaziosmanpaşa University, Faculty of Medicine, 60250 Tokat, TurkeyDepartment of Biochemistry, Gaziosmanpaşa University, Faculty of Medicine, 60250 Tokat, TurkeyDepartment of Obstetrics and Gynecology, İstinye University Medical Park Hospital, 34250 Samsun, TurkeyBackground: Polycystic ovary syndrome (PCOS) is commonly associated with insulin resistance (IR), hyperinsulinemia, and dyslipidemia, which play a role in the development of endothelial dysfunction and promote the early onset of cardiovascular diseases. The aim of this study was to evaluate the clinical importance of pentraxin-3 levels in PCOS patients. Methods: Forty-five female patients diagnosed with PCOS according to the 2003 Rotterdam criteria and 42 healthy women were included in the study. All women studied were tested within 3 and 5 days of their menstrual cycle. Ultrasonographic evaluation of each patient was first conducted using the suprapubic method. Serum PTX-3, endothelin 1 (ET-1), vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and nitric oxide levels were measured using the enzyme-linked immunosorbent assay method. Results: Pentraxine-3 (PTX-3) levels in the patient group were significantly lower than those in the control group (p < 0.05). PTX-3 levels in the group with hirsutism were significantly higher than those in the nonhirsutism group (p < 0.05). Homeostatic model assessment for IR (HOMA-IR) levels in the patient group were significantly higher than those in the control group (p < 0.01). A weak negative correlation was found between PTX-3 and HbA1c levels. The accuracy rate of the PTX-3 test in distinguishing patients and nonpatients was moderate with a 0.634 area-under-the-curve value. Conclusions: During the follow-up of patients with PCOS, a decrease in serum PTX-3 levels associated with hirsutism and IR may be observed.https://www.imrpress.com/journal/CEOG/49/2/10.31083/j.ceog4902038pcosendothelium dysfunctionpentraxin-3homa-ir |
| spellingShingle | Fatih Yeşil Köksal Deveci Pervin Karli Evaluation of the clinical significance of serum pentraxin-3 levels in patients with polycystic ovary syndrome Clinical and Experimental Obstetrics & Gynecology pcos endothelium dysfunction pentraxin-3 homa-ir |
| title | Evaluation of the clinical significance of serum pentraxin-3 levels in patients with polycystic ovary syndrome |
| title_full | Evaluation of the clinical significance of serum pentraxin-3 levels in patients with polycystic ovary syndrome |
| title_fullStr | Evaluation of the clinical significance of serum pentraxin-3 levels in patients with polycystic ovary syndrome |
| title_full_unstemmed | Evaluation of the clinical significance of serum pentraxin-3 levels in patients with polycystic ovary syndrome |
| title_short | Evaluation of the clinical significance of serum pentraxin-3 levels in patients with polycystic ovary syndrome |
| title_sort | evaluation of the clinical significance of serum pentraxin 3 levels in patients with polycystic ovary syndrome |
| topic | pcos endothelium dysfunction pentraxin-3 homa-ir |
| url | https://www.imrpress.com/journal/CEOG/49/2/10.31083/j.ceog4902038 |
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