Maternal vitamin D status and attention deficit hyperactivity disorder (ADHD), an under diagnosed risk factor; A review
Vitamin D is important to mediate several brain processes such as proliferation, apoptosis, and neurotransmission in early stages of life. Vitamin D deficiency during critical periods of development can lead to persistent brain alterations. Vitamin D homeostasis during pregnancy is affected by two f...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-02-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X231161013 |
| _version_ | 1828001609815162880 |
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| author | Hafsa Tahir Naveed Munir Syeda Saira Iqbal Umar Bacha Saira Amir Hassaan Umar Muhammad Riaz Imtiaz Mahmood Tahir Syed Muhammad Ali Shah Almina Shafiq Muhammad Akram |
| author_facet | Hafsa Tahir Naveed Munir Syeda Saira Iqbal Umar Bacha Saira Amir Hassaan Umar Muhammad Riaz Imtiaz Mahmood Tahir Syed Muhammad Ali Shah Almina Shafiq Muhammad Akram |
| author_sort | Hafsa Tahir |
| collection | DOAJ |
| description | Vitamin D is important to mediate several brain processes such as proliferation, apoptosis, and neurotransmission in early stages of life. Vitamin D deficiency during critical periods of development can lead to persistent brain alterations. Vitamin D homeostasis during pregnancy is affected by two factors which includes an increase in mother’s calcitriol levels and an increase in mother’s Vitamin D Binding protein concentrations. Attention deficient hyperactivity disorder (ADHD) is an outcome of a complicated interaction between genetic, environmental, and developmental traits, and genetic factors cover about 80% of the cases. The efficiency of the immune system can be altered by a deficiency of Vitamin D in maternal body and maternal stress during gestation such as perinatal depression. Studies have proved that during gestation if there is a deficiency of vitamin D in maternal body, it can influence the brain development of the fetus and can also alter the synthesis of the brain-derived neurotropic factor. The current manuscript has been compiled to elaborate different factors which are associated with ADHD particularly focusing on the relationship of vitamin D deficiency in mothers. References material was selected from NCBI (PUBMED), Science direct, Google scholar, Publons etc. Using the terms ADHD, Vitamin D and Maternal nutritional status. Although, controversial relationship was found between the deficiency of Vitamin D level in pregnant women and development of ADHD in children but more controlled trials are required for future direction as well as to rule out other associated causes. |
| first_indexed | 2024-04-10T06:31:42Z |
| format | Article |
| id | doaj.art-39fcfd04baeb4e13a280978421831d2e |
| institution | Directory Open Access Journal |
| issn | 2058-7392 |
| language | English |
| last_indexed | 2024-04-10T06:31:42Z |
| publishDate | 2023-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-39fcfd04baeb4e13a280978421831d2e2023-03-01T07:03:15ZengSAGE PublishingEuropean Journal of Inflammation2058-73922023-02-012110.1177/1721727X231161013Maternal vitamin D status and attention deficit hyperactivity disorder (ADHD), an under diagnosed risk factor; A reviewHafsa TahirNaveed MunirSyeda Saira IqbalUmar BachaSaira AmirHassaan UmarMuhammad RiazImtiaz Mahmood TahirSyed Muhammad Ali ShahAlmina ShafiqMuhammad AkramVitamin D is important to mediate several brain processes such as proliferation, apoptosis, and neurotransmission in early stages of life. Vitamin D deficiency during critical periods of development can lead to persistent brain alterations. Vitamin D homeostasis during pregnancy is affected by two factors which includes an increase in mother’s calcitriol levels and an increase in mother’s Vitamin D Binding protein concentrations. Attention deficient hyperactivity disorder (ADHD) is an outcome of a complicated interaction between genetic, environmental, and developmental traits, and genetic factors cover about 80% of the cases. The efficiency of the immune system can be altered by a deficiency of Vitamin D in maternal body and maternal stress during gestation such as perinatal depression. Studies have proved that during gestation if there is a deficiency of vitamin D in maternal body, it can influence the brain development of the fetus and can also alter the synthesis of the brain-derived neurotropic factor. The current manuscript has been compiled to elaborate different factors which are associated with ADHD particularly focusing on the relationship of vitamin D deficiency in mothers. References material was selected from NCBI (PUBMED), Science direct, Google scholar, Publons etc. Using the terms ADHD, Vitamin D and Maternal nutritional status. Although, controversial relationship was found between the deficiency of Vitamin D level in pregnant women and development of ADHD in children but more controlled trials are required for future direction as well as to rule out other associated causes.https://doi.org/10.1177/1721727X231161013 |
| spellingShingle | Hafsa Tahir Naveed Munir Syeda Saira Iqbal Umar Bacha Saira Amir Hassaan Umar Muhammad Riaz Imtiaz Mahmood Tahir Syed Muhammad Ali Shah Almina Shafiq Muhammad Akram Maternal vitamin D status and attention deficit hyperactivity disorder (ADHD), an under diagnosed risk factor; A review European Journal of Inflammation |
| title | Maternal vitamin D status and attention deficit hyperactivity disorder (ADHD), an under diagnosed risk factor; A review |
| title_full | Maternal vitamin D status and attention deficit hyperactivity disorder (ADHD), an under diagnosed risk factor; A review |
| title_fullStr | Maternal vitamin D status and attention deficit hyperactivity disorder (ADHD), an under diagnosed risk factor; A review |
| title_full_unstemmed | Maternal vitamin D status and attention deficit hyperactivity disorder (ADHD), an under diagnosed risk factor; A review |
| title_short | Maternal vitamin D status and attention deficit hyperactivity disorder (ADHD), an under diagnosed risk factor; A review |
| title_sort | maternal vitamin d status and attention deficit hyperactivity disorder adhd an under diagnosed risk factor a review |
| url | https://doi.org/10.1177/1721727X231161013 |
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