Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review
The blood-brain barrier (BBB), which is composed of endothelial cells, pericytes, astrocytes, and neurons, separates the brain extracellular fluid from the circulating blood, and maintains the homeostasis of the central nervous system (CNS). The BBB endothelial cells have well-developed tight juncti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/12/1236 |
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| author | Keisuke Tachibana Yumi Iwashita Erika Wakayama Itsuki Nishino Taiki Nishikaji Masuo Kondoh |
| author_facet | Keisuke Tachibana Yumi Iwashita Erika Wakayama Itsuki Nishino Taiki Nishikaji Masuo Kondoh |
| author_sort | Keisuke Tachibana |
| collection | DOAJ |
| description | The blood-brain barrier (BBB), which is composed of endothelial cells, pericytes, astrocytes, and neurons, separates the brain extracellular fluid from the circulating blood, and maintains the homeostasis of the central nervous system (CNS). The BBB endothelial cells have well-developed tight junctions (TJs) and express specific polarized transport systems to tightly control the paracellular movements of solutes, ions, and water. There are two types of TJs: bicellular TJs (bTJs), which is a structure at the contact of two cells, and tricellular TJs (tTJs), which is a structure at the contact of three cells. Claudin-5 and angulin-1 are important components of bTJs and tTJs in the brain, respectively. Here, we review TJ-modulating bioprobes that enable drug delivery to the brain across the BBB, focusing on claudin-5 and angulin-1. |
| first_indexed | 2024-03-10T13:55:59Z |
| format | Article |
| id | doaj.art-39fda606b47547188c488ab643fb588a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T13:55:59Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-39fda606b47547188c488ab643fb588a2023-11-21T01:37:02ZengMDPI AGPharmaceutics1999-49232020-12-011212123610.3390/pharmaceutics12121236Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A ReviewKeisuke Tachibana0Yumi Iwashita1Erika Wakayama2Itsuki Nishino3Taiki Nishikaji4Masuo Kondoh5Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, JapanGraduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, JapanSchool of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, JapanSchool of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, JapanSchool of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, JapanGraduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, JapanThe blood-brain barrier (BBB), which is composed of endothelial cells, pericytes, astrocytes, and neurons, separates the brain extracellular fluid from the circulating blood, and maintains the homeostasis of the central nervous system (CNS). The BBB endothelial cells have well-developed tight junctions (TJs) and express specific polarized transport systems to tightly control the paracellular movements of solutes, ions, and water. There are two types of TJs: bicellular TJs (bTJs), which is a structure at the contact of two cells, and tricellular TJs (tTJs), which is a structure at the contact of three cells. Claudin-5 and angulin-1 are important components of bTJs and tTJs in the brain, respectively. Here, we review TJ-modulating bioprobes that enable drug delivery to the brain across the BBB, focusing on claudin-5 and angulin-1.https://www.mdpi.com/1999-4923/12/12/1236blood-brain barrier (BBB)tight junction (TJ)claudinangulinangubindin-1antibody |
| spellingShingle | Keisuke Tachibana Yumi Iwashita Erika Wakayama Itsuki Nishino Taiki Nishikaji Masuo Kondoh Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review Pharmaceutics blood-brain barrier (BBB) tight junction (TJ) claudin angulin angubindin-1 antibody |
| title | Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review |
| title_full | Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review |
| title_fullStr | Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review |
| title_full_unstemmed | Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review |
| title_short | Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review |
| title_sort | tight junction modulating bioprobes for drug delivery system to the brain a review |
| topic | blood-brain barrier (BBB) tight junction (TJ) claudin angulin angubindin-1 antibody |
| url | https://www.mdpi.com/1999-4923/12/12/1236 |
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