Effects of trans‐ versus cis‐resveratrol on adrenergic contractions of the rat tail artery and role of endothelium
Abstract The health benefits of the natural polyphenol trans‐resveratrol may play an important role in preventing a variety of diseases. Resveratrol has been shown to reduce blood pressure and improve metabolic diseases such as type 2 diabetes mellitus and obesity. Our previous studies examined the...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.14666 |
| _version_ | 1818345042290409472 |
|---|---|
| author | Ian R. VanAntwerp Laura E. Phelps Jacob D. Peuler Phillip G. Kopf |
| author_facet | Ian R. VanAntwerp Laura E. Phelps Jacob D. Peuler Phillip G. Kopf |
| author_sort | Ian R. VanAntwerp |
| collection | DOAJ |
| description | Abstract The health benefits of the natural polyphenol trans‐resveratrol may play an important role in preventing a variety of diseases. Resveratrol has been shown to reduce blood pressure and improve metabolic diseases such as type 2 diabetes mellitus and obesity. Our previous studies examined the role of K+ channels in the vasorelaxation responses to trans‐resveratrol in the rat tail artery. During these studies, we uncovered a novel transient contraction prior to the sustained relaxation effect of trans‐resveratrol. Thus, the purpose of this study was to determine the role of the endothelium in these vascular contraction and relaxation responses to trans‐resveratrol. We additionally sought to determine if the cis‐isomer of resveratrol exerts any of the same vascular effects as the trans‐isomer. The vascular responses to trans‐resveratrol were examined in rat tail arteries with intact or denuded endothelium over a 2‐hr period. Additionally, the vascular responses to trans‐ and cis‐resveratrol were compared in rat tail arteries with intact endothelium. Both the transient contractile response and the persistent relaxation response to trans‐resveratrol were similar in the arterial rings with intact or denuded endothelium. There was a significant correlation between the initial contraction‐enhancing action of trans‐resveratrol and the magnitude of the sustained relaxation for vessels with both intact and denuded endothelium. Moreover, we demonstrated that cis‐resveratrol produced a significantly greater relaxation response as compared to trans‐resveratrol without the initial contractile response. These data demonstrate the role of the vascular smooth muscle in the vascular responses to resveratrol and the potential clinical benefits of the cis‐isomer of resveratrol as compared to the trans‐isomer. |
| first_indexed | 2024-12-13T16:56:05Z |
| format | Article |
| id | doaj.art-39fe7ca2e9e24e5f97c40cd004074736 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-13T16:56:05Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-39fe7ca2e9e24e5f97c40cd0040747362022-12-21T23:37:54ZengWileyPhysiological Reports2051-817X2021-01-01824n/an/a10.14814/phy2.14666Effects of trans‐ versus cis‐resveratrol on adrenergic contractions of the rat tail artery and role of endotheliumIan R. VanAntwerp0Laura E. Phelps1Jacob D. Peuler2Phillip G. Kopf3Department of Pharmacology Midwestern University Downers Grove IL USADepartment of Pharmacology Midwestern University Downers Grove IL USADepartment of Pharmacology Midwestern University Downers Grove IL USADepartment of Pharmacology Midwestern University Downers Grove IL USAAbstract The health benefits of the natural polyphenol trans‐resveratrol may play an important role in preventing a variety of diseases. Resveratrol has been shown to reduce blood pressure and improve metabolic diseases such as type 2 diabetes mellitus and obesity. Our previous studies examined the role of K+ channels in the vasorelaxation responses to trans‐resveratrol in the rat tail artery. During these studies, we uncovered a novel transient contraction prior to the sustained relaxation effect of trans‐resveratrol. Thus, the purpose of this study was to determine the role of the endothelium in these vascular contraction and relaxation responses to trans‐resveratrol. We additionally sought to determine if the cis‐isomer of resveratrol exerts any of the same vascular effects as the trans‐isomer. The vascular responses to trans‐resveratrol were examined in rat tail arteries with intact or denuded endothelium over a 2‐hr period. Additionally, the vascular responses to trans‐ and cis‐resveratrol were compared in rat tail arteries with intact endothelium. Both the transient contractile response and the persistent relaxation response to trans‐resveratrol were similar in the arterial rings with intact or denuded endothelium. There was a significant correlation between the initial contraction‐enhancing action of trans‐resveratrol and the magnitude of the sustained relaxation for vessels with both intact and denuded endothelium. Moreover, we demonstrated that cis‐resveratrol produced a significantly greater relaxation response as compared to trans‐resveratrol without the initial contractile response. These data demonstrate the role of the vascular smooth muscle in the vascular responses to resveratrol and the potential clinical benefits of the cis‐isomer of resveratrol as compared to the trans‐isomer.https://doi.org/10.14814/phy2.14666adrenergic contractionscis‐isomerendotheliumrat tail arteryresveratrol |
| spellingShingle | Ian R. VanAntwerp Laura E. Phelps Jacob D. Peuler Phillip G. Kopf Effects of trans‐ versus cis‐resveratrol on adrenergic contractions of the rat tail artery and role of endothelium Physiological Reports adrenergic contractions cis‐isomer endothelium rat tail artery resveratrol |
| title | Effects of trans‐ versus cis‐resveratrol on adrenergic contractions of the rat tail artery and role of endothelium |
| title_full | Effects of trans‐ versus cis‐resveratrol on adrenergic contractions of the rat tail artery and role of endothelium |
| title_fullStr | Effects of trans‐ versus cis‐resveratrol on adrenergic contractions of the rat tail artery and role of endothelium |
| title_full_unstemmed | Effects of trans‐ versus cis‐resveratrol on adrenergic contractions of the rat tail artery and role of endothelium |
| title_short | Effects of trans‐ versus cis‐resveratrol on adrenergic contractions of the rat tail artery and role of endothelium |
| title_sort | effects of trans versus cis resveratrol on adrenergic contractions of the rat tail artery and role of endothelium |
| topic | adrenergic contractions cis‐isomer endothelium rat tail artery resveratrol |
| url | https://doi.org/10.14814/phy2.14666 |
| work_keys_str_mv | AT ianrvanantwerp effectsoftransversuscisresveratrolonadrenergiccontractionsoftherattailarteryandroleofendothelium AT lauraephelps effectsoftransversuscisresveratrolonadrenergiccontractionsoftherattailarteryandroleofendothelium AT jacobdpeuler effectsoftransversuscisresveratrolonadrenergiccontractionsoftherattailarteryandroleofendothelium AT phillipgkopf effectsoftransversuscisresveratrolonadrenergiccontractionsoftherattailarteryandroleofendothelium |