The human microbiome in evolution
Abstract The trillions of microbes living in the gut—the gut microbiota—play an important role in human biology and disease. While much has been done to explore its diversity, a full understanding of our microbiomes demands an evolutionary perspective. In this review, we compare microbiomes from hum...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | BMC Biology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12915-017-0454-7 |
| _version_ | 1819040101259280384 |
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| author | Emily R. Davenport Jon G. Sanders Se Jin Song Katherine R. Amato Andrew G. Clark Rob Knight |
| author_facet | Emily R. Davenport Jon G. Sanders Se Jin Song Katherine R. Amato Andrew G. Clark Rob Knight |
| author_sort | Emily R. Davenport |
| collection | DOAJ |
| description | Abstract The trillions of microbes living in the gut—the gut microbiota—play an important role in human biology and disease. While much has been done to explore its diversity, a full understanding of our microbiomes demands an evolutionary perspective. In this review, we compare microbiomes from human populations, placing them in the context of microbes from humanity’s near and distant animal relatives. We discuss potential mechanisms to generate host-specific microbiome configurations and the consequences of disrupting those configurations. Finally, we propose that this broader phylogenetic perspective is useful for understanding the mechanisms underlying human–microbiome interactions. |
| first_indexed | 2024-12-21T09:03:45Z |
| format | Article |
| id | doaj.art-39ffd08adcb44972b3478cd48293499b |
| institution | Directory Open Access Journal |
| issn | 1741-7007 |
| language | English |
| last_indexed | 2024-12-21T09:03:45Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj.art-39ffd08adcb44972b3478cd48293499b2022-12-21T19:09:25ZengBMCBMC Biology1741-70072017-12-0115111210.1186/s12915-017-0454-7The human microbiome in evolutionEmily R. Davenport0Jon G. Sanders1Se Jin Song2Katherine R. Amato3Andrew G. Clark4Rob Knight5Department of Molecular Biology and Genetics, Cornell UniversityDepartment of Pediatrics, University of California San DiegoDepartment of Pediatrics, University of California San DiegoDepartment of Anthropology, Northwestern UniversityDepartment of Molecular Biology and Genetics, Cornell UniversityDepartment of Pediatrics, University of California San DiegoAbstract The trillions of microbes living in the gut—the gut microbiota—play an important role in human biology and disease. While much has been done to explore its diversity, a full understanding of our microbiomes demands an evolutionary perspective. In this review, we compare microbiomes from human populations, placing them in the context of microbes from humanity’s near and distant animal relatives. We discuss potential mechanisms to generate host-specific microbiome configurations and the consequences of disrupting those configurations. Finally, we propose that this broader phylogenetic perspective is useful for understanding the mechanisms underlying human–microbiome interactions.http://link.springer.com/article/10.1186/s12915-017-0454-7MicrobiomeEvolutionCodiversificationHabitat filteringTransmission |
| spellingShingle | Emily R. Davenport Jon G. Sanders Se Jin Song Katherine R. Amato Andrew G. Clark Rob Knight The human microbiome in evolution BMC Biology Microbiome Evolution Codiversification Habitat filtering Transmission |
| title | The human microbiome in evolution |
| title_full | The human microbiome in evolution |
| title_fullStr | The human microbiome in evolution |
| title_full_unstemmed | The human microbiome in evolution |
| title_short | The human microbiome in evolution |
| title_sort | human microbiome in evolution |
| topic | Microbiome Evolution Codiversification Habitat filtering Transmission |
| url | http://link.springer.com/article/10.1186/s12915-017-0454-7 |
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