Determinants of drug-resistant tuberculosis in Hunan province, China: a case-control study
Abstract Background Drug-resistant tuberculosis (DR-TB) is a major public health threat in Hunan Province, with an increasing clinical burden in recent years. This study aimed to identify socio-demographic and clinical factors associated with DR-TB in Hunan province, China. Methods A case-control st...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-024-09106-5 |
| _version_ | 1797275673574768640 |
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| author | Temesgen Yihunie Akalu Archie C. A. Clements Zuhui Xu Liqiong Bai Kefyalew Addis Alene |
| author_facet | Temesgen Yihunie Akalu Archie C. A. Clements Zuhui Xu Liqiong Bai Kefyalew Addis Alene |
| author_sort | Temesgen Yihunie Akalu |
| collection | DOAJ |
| description | Abstract Background Drug-resistant tuberculosis (DR-TB) is a major public health threat in Hunan Province, with an increasing clinical burden in recent years. This study aimed to identify socio-demographic and clinical factors associated with DR-TB in Hunan province, China. Methods A case-control study was conducted in Hunan province. Cases were all DR-TB patients who were confirmed by culture and Drug susceptibility testing (DST) and enrolled at the DR-TB treatment center of Hunan Chest Hospital from 2013 to 2018. Controls were all Drug Susceptible TB (DS-TB) patients confirmed by DST and enrolled at the same hospital during the same period. A multivariable logistic regression model was fitted to identify factors significantly associated with DR-TB. Results A total of 17,808 patients (15,534 DS-TB controls and 2274 DR-TB cases) were included in the study, with a mean age of 42.5 years (standard deviation (SD) ± 17.5 years) for cases and 46.1 years (SD ± 19.1 years) for controls. Age 15-64 years (Adjusted odds ratio (AOR = 1.5, 95% CI; 1.4, 1.8)), ethnic minorities (AOR = 1.5; 95% CI; 1.4, 1.8), and a history of previous TB treatment (AOR) = 1.84; 95% CI: 1.57, 2.15) was significantly associated with DR-TB. Being resident in a province outside Hunan was also a significant risk factor (AOR = 1.67; 1.27, 2.21) for DR-TB. Conclusion and recommendations To prevent the occurrence of DR-TB in Hunan Province, interventions should be targeted at high-risk demographic groups such as ethnic minorities, individuals of productive age, and residents living outside the province. Interventions must also be targeted to previously treated cases, suggesting the appropriateness of diagnosis, treatment, and follow-up. Understanding the risk factors at the province level helps design strategies for controlling DR-TB due to variations by socioeconomic differences, quality of health care, and healthcare access. |
| first_indexed | 2024-03-07T15:17:52Z |
| format | Article |
| id | doaj.art-39ffd361aaf04b37907227dc00f18749 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-07T15:17:52Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-39ffd361aaf04b37907227dc00f187492024-03-05T17:48:51ZengBMCBMC Infectious Diseases1471-23342024-02-012411810.1186/s12879-024-09106-5Determinants of drug-resistant tuberculosis in Hunan province, China: a case-control studyTemesgen Yihunie Akalu0Archie C. A. Clements1Zuhui Xu2Liqiong Bai3Kefyalew Addis Alene4School of Population Health, Faculty of Health Sciences, Curtin UniversityGeospatial and Tuberculosis Research Team, Telethon Kids InstituteXiangya School of Public Health, Central South UniversityTB Control Institute of Hunan ProvinceSchool of Population Health, Faculty of Health Sciences, Curtin UniversityAbstract Background Drug-resistant tuberculosis (DR-TB) is a major public health threat in Hunan Province, with an increasing clinical burden in recent years. This study aimed to identify socio-demographic and clinical factors associated with DR-TB in Hunan province, China. Methods A case-control study was conducted in Hunan province. Cases were all DR-TB patients who were confirmed by culture and Drug susceptibility testing (DST) and enrolled at the DR-TB treatment center of Hunan Chest Hospital from 2013 to 2018. Controls were all Drug Susceptible TB (DS-TB) patients confirmed by DST and enrolled at the same hospital during the same period. A multivariable logistic regression model was fitted to identify factors significantly associated with DR-TB. Results A total of 17,808 patients (15,534 DS-TB controls and 2274 DR-TB cases) were included in the study, with a mean age of 42.5 years (standard deviation (SD) ± 17.5 years) for cases and 46.1 years (SD ± 19.1 years) for controls. Age 15-64 years (Adjusted odds ratio (AOR = 1.5, 95% CI; 1.4, 1.8)), ethnic minorities (AOR = 1.5; 95% CI; 1.4, 1.8), and a history of previous TB treatment (AOR) = 1.84; 95% CI: 1.57, 2.15) was significantly associated with DR-TB. Being resident in a province outside Hunan was also a significant risk factor (AOR = 1.67; 1.27, 2.21) for DR-TB. Conclusion and recommendations To prevent the occurrence of DR-TB in Hunan Province, interventions should be targeted at high-risk demographic groups such as ethnic minorities, individuals of productive age, and residents living outside the province. Interventions must also be targeted to previously treated cases, suggesting the appropriateness of diagnosis, treatment, and follow-up. Understanding the risk factors at the province level helps design strategies for controlling DR-TB due to variations by socioeconomic differences, quality of health care, and healthcare access.https://doi.org/10.1186/s12879-024-09106-5Case-controlDeterminantsHunan ProvinceDrug-resistant tuberculosis |
| spellingShingle | Temesgen Yihunie Akalu Archie C. A. Clements Zuhui Xu Liqiong Bai Kefyalew Addis Alene Determinants of drug-resistant tuberculosis in Hunan province, China: a case-control study BMC Infectious Diseases Case-control Determinants Hunan Province Drug-resistant tuberculosis |
| title | Determinants of drug-resistant tuberculosis in Hunan province, China: a case-control study |
| title_full | Determinants of drug-resistant tuberculosis in Hunan province, China: a case-control study |
| title_fullStr | Determinants of drug-resistant tuberculosis in Hunan province, China: a case-control study |
| title_full_unstemmed | Determinants of drug-resistant tuberculosis in Hunan province, China: a case-control study |
| title_short | Determinants of drug-resistant tuberculosis in Hunan province, China: a case-control study |
| title_sort | determinants of drug resistant tuberculosis in hunan province china a case control study |
| topic | Case-control Determinants Hunan Province Drug-resistant tuberculosis |
| url | https://doi.org/10.1186/s12879-024-09106-5 |
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