Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population
Abstract Background Susceptibility to Chronic Myeloid Leukemia (CML) may be modulated by genetic variables. However, the majority of previous investigations have focused on genetically homogeneous populations, resulting in a lack of evidence on how genetic factors may influence the development of CM...
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| Format: | Article |
| Language: | English |
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Wiley
2021-07-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.1694 |
| _version_ | 1818458124106858496 |
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| author | Natasha Monte Karla B. C. C. Pantoja Juliana C. G. Rodrigues Darlen C. deCarvalho Tereza C. B. Azevedo Esdras E. B. Pereira Paulo P. deAssumpção Sidney E. B. dosSantos Marianne R. Fernandes Ney P. C. dosSantos |
| author_facet | Natasha Monte Karla B. C. C. Pantoja Juliana C. G. Rodrigues Darlen C. deCarvalho Tereza C. B. Azevedo Esdras E. B. Pereira Paulo P. deAssumpção Sidney E. B. dosSantos Marianne R. Fernandes Ney P. C. dosSantos |
| author_sort | Natasha Monte |
| collection | DOAJ |
| description | Abstract Background Susceptibility to Chronic Myeloid Leukemia (CML) may be modulated by genetic variables. However, the majority of previous investigations have focused on genetically homogeneous populations, resulting in a lack of evidence on how genetic factors may influence the development of CML in miscegenated populations. We analyzed 30 polymorphisms in genes related to DNA repair, folate metabolism, transmembrane transport, xenobiotic metabolism, and pyrimidine synthesis in relation to their potential role in the susceptibility of the individual to CML. Methods This case‐control study included 126 healthy individuals and 143 patients diagnosed with CML from the admixed population of the Brazilian Amazon. The samples were genotyped by real‐time PCR and the genetic ancestry analysis was based on a panel of 61 ancestry informative markers. Results The results indicated a protective effect against the development of CML in carriers of the C allele of the rs28399433 (CYP2A6) gene and the CC genotype of the rs3742106 (ABCC4) gene. Conclusion Our findings suggest that the rs3742106 (ABCC4) and rs28399433 (CYP2A6) polymorphisms may modulate susceptibility to CML in a population of the Brazilian Amazon region. |
| first_indexed | 2024-12-14T22:53:28Z |
| format | Article |
| id | doaj.art-3a00af5bb12d46e5b5cb8b08f7ea8310 |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-12-14T22:53:28Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-3a00af5bb12d46e5b5cb8b08f7ea83102022-12-21T22:44:38ZengWileyMolecular Genetics & Genomic Medicine2324-92692021-07-0197n/an/a10.1002/mgg3.1694Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon populationNatasha Monte0Karla B. C. C. Pantoja1Juliana C. G. Rodrigues2Darlen C. deCarvalho3Tereza C. B. Azevedo4Esdras E. B. Pereira5Paulo P. deAssumpção6Sidney E. B. dosSantos7Marianne R. Fernandes8Ney P. C. dosSantos9Núcleo de Pesquisas em Oncologia Instituto de Ciências BiológicasUniversidade Federal do ParáHospital Universitário João de Barros BarretoUnidade de Alta Complexidade em Oncologia Belém BrazilNúcleo de Pesquisas em Oncologia Instituto de Ciências BiológicasUniversidade Federal do ParáHospital Universitário João de Barros BarretoUnidade de Alta Complexidade em Oncologia Belém BrazilNúcleo de Pesquisas em Oncologia Instituto de Ciências BiológicasUniversidade Federal do ParáHospital Universitário João de Barros BarretoUnidade de Alta Complexidade em Oncologia Belém BrazilNúcleo de Pesquisas em Oncologia Instituto de Ciências BiológicasUniversidade Federal do ParáHospital Universitário João de Barros BarretoUnidade de Alta Complexidade em Oncologia Belém BrazilDepartamento de Oncohematologia Hospital Ophir Loyola Belém BrazilNúcleo de Pesquisas em Oncologia Instituto de Ciências BiológicasUniversidade Federal do ParáHospital Universitário João de Barros BarretoUnidade de Alta Complexidade em Oncologia Belém BrazilNúcleo de Pesquisas em Oncologia Instituto de Ciências BiológicasUniversidade Federal do ParáHospital Universitário João de Barros BarretoUnidade de Alta Complexidade em Oncologia Belém BrazilNúcleo de Pesquisas em Oncologia Instituto de Ciências BiológicasUniversidade Federal do ParáHospital Universitário João de Barros BarretoUnidade de Alta Complexidade em Oncologia Belém BrazilNúcleo de Pesquisas em Oncologia Instituto de Ciências BiológicasUniversidade Federal do ParáHospital Universitário João de Barros BarretoUnidade de Alta Complexidade em Oncologia Belém BrazilNúcleo de Pesquisas em Oncologia Instituto de Ciências BiológicasUniversidade Federal do ParáHospital Universitário João de Barros BarretoUnidade de Alta Complexidade em Oncologia Belém BrazilAbstract Background Susceptibility to Chronic Myeloid Leukemia (CML) may be modulated by genetic variables. However, the majority of previous investigations have focused on genetically homogeneous populations, resulting in a lack of evidence on how genetic factors may influence the development of CML in miscegenated populations. We analyzed 30 polymorphisms in genes related to DNA repair, folate metabolism, transmembrane transport, xenobiotic metabolism, and pyrimidine synthesis in relation to their potential role in the susceptibility of the individual to CML. Methods This case‐control study included 126 healthy individuals and 143 patients diagnosed with CML from the admixed population of the Brazilian Amazon. The samples were genotyped by real‐time PCR and the genetic ancestry analysis was based on a panel of 61 ancestry informative markers. Results The results indicated a protective effect against the development of CML in carriers of the C allele of the rs28399433 (CYP2A6) gene and the CC genotype of the rs3742106 (ABCC4) gene. Conclusion Our findings suggest that the rs3742106 (ABCC4) and rs28399433 (CYP2A6) polymorphisms may modulate susceptibility to CML in a population of the Brazilian Amazon region.https://doi.org/10.1002/mgg3.1694ABCC4ancestrychronic myeloid leukemiaCYP2A6genetic susceptibility |
| spellingShingle | Natasha Monte Karla B. C. C. Pantoja Juliana C. G. Rodrigues Darlen C. deCarvalho Tereza C. B. Azevedo Esdras E. B. Pereira Paulo P. deAssumpção Sidney E. B. dosSantos Marianne R. Fernandes Ney P. C. dosSantos Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population Molecular Genetics & Genomic Medicine ABCC4 ancestry chronic myeloid leukemia CYP2A6 genetic susceptibility |
| title | Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population |
| title_full | Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population |
| title_fullStr | Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population |
| title_full_unstemmed | Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population |
| title_short | Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population |
| title_sort | polymorphisms in the cyp2a6 and abcc4 genes are associated with a protective effect on chronic myeloid leukemia in the brazilian amazon population |
| topic | ABCC4 ancestry chronic myeloid leukemia CYP2A6 genetic susceptibility |
| url | https://doi.org/10.1002/mgg3.1694 |
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