Cervical Vertebral Maturation Method: Reproducibility and Efficiency of Chronological Age Estimation

The aim of this study was to investigate the reproducibility of the Cervical Vertebral Maturation (CVM) method and the potential for chronological age estimation using this method. The sample consisted of 474 lateral cephalometric radiographs, from orthodontic patients aged 6.4–22.4 years. Six rater...

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Main Authors: Lydia Schoretsaniti, Anastasia Mitsea, Kety Karayianni, Iosif Sifakakis
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Applied Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3417/11/7/3160
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author Lydia Schoretsaniti
Anastasia Mitsea
Kety Karayianni
Iosif Sifakakis
author_facet Lydia Schoretsaniti
Anastasia Mitsea
Kety Karayianni
Iosif Sifakakis
author_sort Lydia Schoretsaniti
collection DOAJ
description The aim of this study was to investigate the reproducibility of the Cervical Vertebral Maturation (CVM) method and the potential for chronological age estimation using this method. The sample consisted of 474 lateral cephalometric radiographs, from orthodontic patients aged 6.4–22.4 years. Six raters were trained to the CVM method (Baccetti). All images were assessed twice. Intra- and inter-rater agreements were assessed by Cohen’s weighted kappa and intraclass correlation coefficient, respectively. Analysis of variance was performed to investigate the correlation between cervical maturation stages and chronological age. The age prediction potential of the method was tested by general linear model regression analysis. Intra-rater reliability ranged from 0.857 to 0.931. Intra-rater absolute agreement ranged from 77% to 87% however inter-rater absolute agreement was lower than 50%. Inter-rater reliability was higher than 0.9. The 3rd Cervical Maturation Stage (CS3) showed the lowest reproducibility. The mean age differences among the 6 CS stages were statistically significant and increased as the CS increased. CS and gender could roughly explain the 60% (adjusted <i>R</i><sup>2</sup> = 0.61) of the age variance of the sample. This CVM method proved able to show high reliability; however, it cannot predict accurately the pubertal growth spurt. A direct correlation was found between cervical stages and chronological age. This method provides a broad estimation of chronological age.
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spelling doaj.art-3a011e2eee3840ae92d778c4ec607c582023-11-21T13:53:33ZengMDPI AGApplied Sciences2076-34172021-04-01117316010.3390/app11073160Cervical Vertebral Maturation Method: Reproducibility and Efficiency of Chronological Age EstimationLydia Schoretsaniti0Anastasia Mitsea1Kety Karayianni2Iosif Sifakakis3Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Oral Diagnosis & Radiology, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Oral Diagnosis & Radiology, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, GreeceThe aim of this study was to investigate the reproducibility of the Cervical Vertebral Maturation (CVM) method and the potential for chronological age estimation using this method. The sample consisted of 474 lateral cephalometric radiographs, from orthodontic patients aged 6.4–22.4 years. Six raters were trained to the CVM method (Baccetti). All images were assessed twice. Intra- and inter-rater agreements were assessed by Cohen’s weighted kappa and intraclass correlation coefficient, respectively. Analysis of variance was performed to investigate the correlation between cervical maturation stages and chronological age. The age prediction potential of the method was tested by general linear model regression analysis. Intra-rater reliability ranged from 0.857 to 0.931. Intra-rater absolute agreement ranged from 77% to 87% however inter-rater absolute agreement was lower than 50%. Inter-rater reliability was higher than 0.9. The 3rd Cervical Maturation Stage (CS3) showed the lowest reproducibility. The mean age differences among the 6 CS stages were statistically significant and increased as the CS increased. CS and gender could roughly explain the 60% (adjusted <i>R</i><sup>2</sup> = 0.61) of the age variance of the sample. This CVM method proved able to show high reliability; however, it cannot predict accurately the pubertal growth spurt. A direct correlation was found between cervical stages and chronological age. This method provides a broad estimation of chronological age.https://www.mdpi.com/2076-3417/11/7/3160agecervical vertebraeskeletal maturation
spellingShingle Lydia Schoretsaniti
Anastasia Mitsea
Kety Karayianni
Iosif Sifakakis
Cervical Vertebral Maturation Method: Reproducibility and Efficiency of Chronological Age Estimation
Applied Sciences
age
cervical vertebrae
skeletal maturation
title Cervical Vertebral Maturation Method: Reproducibility and Efficiency of Chronological Age Estimation
title_full Cervical Vertebral Maturation Method: Reproducibility and Efficiency of Chronological Age Estimation
title_fullStr Cervical Vertebral Maturation Method: Reproducibility and Efficiency of Chronological Age Estimation
title_full_unstemmed Cervical Vertebral Maturation Method: Reproducibility and Efficiency of Chronological Age Estimation
title_short Cervical Vertebral Maturation Method: Reproducibility and Efficiency of Chronological Age Estimation
title_sort cervical vertebral maturation method reproducibility and efficiency of chronological age estimation
topic age
cervical vertebrae
skeletal maturation
url https://www.mdpi.com/2076-3417/11/7/3160
work_keys_str_mv AT lydiaschoretsaniti cervicalvertebralmaturationmethodreproducibilityandefficiencyofchronologicalageestimation
AT anastasiamitsea cervicalvertebralmaturationmethodreproducibilityandefficiencyofchronologicalageestimation
AT ketykarayianni cervicalvertebralmaturationmethodreproducibilityandefficiencyofchronologicalageestimation
AT iosifsifakakis cervicalvertebralmaturationmethodreproducibilityandefficiencyofchronologicalageestimation