Physiological Actions of Fibroblast Growth Factor-23

Physiological Actions of Fibroblast Growth Factor-23

Fibroblast growth factor-23 (FGF23) is a bone-derived hormone suppressing phosphate reabsorption and vitamin D hormone synthesis in the kidney. At physiological concentrations of the hormone, the endocrine actions of FGF23 in the kidney are αKlotho-dependent, because high-affinity binding of FGF23 t...

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Bibliographic Details
Main Author:	Reinhold G. Erben
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-05-01
Series:	Frontiers in Endocrinology
Subjects:	fibroblast growth factor-23 Klotho vitamin D 1α-hydroxylase bone mineralization phosphate metabolism
Online Access:	https://www.frontiersin.org/article/10.3389/fendo.2018.00267/full

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