Determinants of compliance with malaria chemoprophylaxis among French soldiers during missions in inter-tropical Africa
<p>Abstract</p> <p>Background</p> <p>The effectiveness of malaria chemoprophylaxis is limited by the lack of compliance whose determinants are not well known.</p> <p>Methods</p> <p>The compliance with malaria chemoprophylaxis has been estimated a...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-02-01
|
| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/9/1/41 |
| _version_ | 1818050579730006016 |
|---|---|
| author | Pradines Bruno Texier Gaetan Orlandi-Pradines Eve Ollivier Lénaick Machault Vanessa Resseguier Noémie Gaudart Jean Buguet Alain Tourette-Turgis Catherine Rogier Christophe |
| author_facet | Pradines Bruno Texier Gaetan Orlandi-Pradines Eve Ollivier Lénaick Machault Vanessa Resseguier Noémie Gaudart Jean Buguet Alain Tourette-Turgis Catherine Rogier Christophe |
| author_sort | Pradines Bruno |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The effectiveness of malaria chemoprophylaxis is limited by the lack of compliance whose determinants are not well known.</p> <p>Methods</p> <p>The compliance with malaria chemoprophylaxis has been estimated and analysed by validated questionnaires administered before and after the short-term missions (about four months) in five tropical African countries of 2,093 French soldiers from 19 military companies involved in a prospective cohort study. "Correct compliance" was defined as "no missed doses" of daily drug intake during the entire mission and was analysed using multiple mixed-effect logistic regression model.</p> <p>Results</p> <p>The averaged prevalence rate of correct compliance was 46.2%, ranging from 9.6%to 76.6% according to the companies. Incorrect compliance was significantly associated with eveningness (p = 0.028), a medical history of clinical malaria (p < 0.001) and a perceived mosquito attractiveness inferior or superior to the others (p < 0.007). Correct compliance was significantly associated with the systematic use of protective measures against mosquito bites (p < 0.001), the type of military operations (combat vs. training activities, p < 0.001) and other individual factors (p < 0.05).</p> <p>Conclusions</p> <p>The identification of circumstances and profiles of persons at higher risk of lack of compliance would pave the way to specifically targeted strategies aimed to improve compliance with malaria chemoprophylaxis and, therefore, its effectiveness.</p> |
| first_indexed | 2024-12-10T10:55:43Z |
| format | Article |
| id | doaj.art-3a02a7dfe36442e6811d9d2ce747ee86 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-10T10:55:43Z |
| publishDate | 2010-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-3a02a7dfe36442e6811d9d2ce747ee862022-12-22T01:51:53ZengBMCMalaria Journal1475-28752010-02-01914110.1186/1475-2875-9-41Determinants of compliance with malaria chemoprophylaxis among French soldiers during missions in inter-tropical AfricaPradines BrunoTexier GaetanOrlandi-Pradines EveOllivier LénaickMachault VanessaResseguier NoémieGaudart JeanBuguet AlainTourette-Turgis CatherineRogier Christophe<p>Abstract</p> <p>Background</p> <p>The effectiveness of malaria chemoprophylaxis is limited by the lack of compliance whose determinants are not well known.</p> <p>Methods</p> <p>The compliance with malaria chemoprophylaxis has been estimated and analysed by validated questionnaires administered before and after the short-term missions (about four months) in five tropical African countries of 2,093 French soldiers from 19 military companies involved in a prospective cohort study. "Correct compliance" was defined as "no missed doses" of daily drug intake during the entire mission and was analysed using multiple mixed-effect logistic regression model.</p> <p>Results</p> <p>The averaged prevalence rate of correct compliance was 46.2%, ranging from 9.6%to 76.6% according to the companies. Incorrect compliance was significantly associated with eveningness (p = 0.028), a medical history of clinical malaria (p < 0.001) and a perceived mosquito attractiveness inferior or superior to the others (p < 0.007). Correct compliance was significantly associated with the systematic use of protective measures against mosquito bites (p < 0.001), the type of military operations (combat vs. training activities, p < 0.001) and other individual factors (p < 0.05).</p> <p>Conclusions</p> <p>The identification of circumstances and profiles of persons at higher risk of lack of compliance would pave the way to specifically targeted strategies aimed to improve compliance with malaria chemoprophylaxis and, therefore, its effectiveness.</p>http://www.malariajournal.com/content/9/1/41 |
| spellingShingle | Pradines Bruno Texier Gaetan Orlandi-Pradines Eve Ollivier Lénaick Machault Vanessa Resseguier Noémie Gaudart Jean Buguet Alain Tourette-Turgis Catherine Rogier Christophe Determinants of compliance with malaria chemoprophylaxis among French soldiers during missions in inter-tropical Africa Malaria Journal |
| title | Determinants of compliance with malaria chemoprophylaxis among French soldiers during missions in inter-tropical Africa |
| title_full | Determinants of compliance with malaria chemoprophylaxis among French soldiers during missions in inter-tropical Africa |
| title_fullStr | Determinants of compliance with malaria chemoprophylaxis among French soldiers during missions in inter-tropical Africa |
| title_full_unstemmed | Determinants of compliance with malaria chemoprophylaxis among French soldiers during missions in inter-tropical Africa |
| title_short | Determinants of compliance with malaria chemoprophylaxis among French soldiers during missions in inter-tropical Africa |
| title_sort | determinants of compliance with malaria chemoprophylaxis among french soldiers during missions in inter tropical africa |
| url | http://www.malariajournal.com/content/9/1/41 |
| work_keys_str_mv | AT pradinesbruno determinantsofcompliancewithmalariachemoprophylaxisamongfrenchsoldiersduringmissionsinintertropicalafrica AT texiergaetan determinantsofcompliancewithmalariachemoprophylaxisamongfrenchsoldiersduringmissionsinintertropicalafrica AT orlandipradineseve determinantsofcompliancewithmalariachemoprophylaxisamongfrenchsoldiersduringmissionsinintertropicalafrica AT ollivierlenaick determinantsofcompliancewithmalariachemoprophylaxisamongfrenchsoldiersduringmissionsinintertropicalafrica AT machaultvanessa determinantsofcompliancewithmalariachemoprophylaxisamongfrenchsoldiersduringmissionsinintertropicalafrica AT resseguiernoemie determinantsofcompliancewithmalariachemoprophylaxisamongfrenchsoldiersduringmissionsinintertropicalafrica AT gaudartjean determinantsofcompliancewithmalariachemoprophylaxisamongfrenchsoldiersduringmissionsinintertropicalafrica AT buguetalain determinantsofcompliancewithmalariachemoprophylaxisamongfrenchsoldiersduringmissionsinintertropicalafrica AT touretteturgiscatherine determinantsofcompliancewithmalariachemoprophylaxisamongfrenchsoldiersduringmissionsinintertropicalafrica AT rogierchristophe determinantsofcompliancewithmalariachemoprophylaxisamongfrenchsoldiersduringmissionsinintertropicalafrica |