11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases
Glucocorticoids (GCs) belong to the group of steroid hormones. Their representative in humans is cortisol. GCs are involved in most physiological processes of the body and play a significant role in important biological processes, including reproduction, growth, immune responses, metabolism, mainten...
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/20/6190 |
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| author | Daria Kupczyk Renata Studzińska Renata Kołodziejska Szymon Baumgart Martyna Modrzejewska Alina Woźniak |
| author_facet | Daria Kupczyk Renata Studzińska Renata Kołodziejska Szymon Baumgart Martyna Modrzejewska Alina Woźniak |
| author_sort | Daria Kupczyk |
| collection | DOAJ |
| description | Glucocorticoids (GCs) belong to the group of steroid hormones. Their representative in humans is cortisol. GCs are involved in most physiological processes of the body and play a significant role in important biological processes, including reproduction, growth, immune responses, metabolism, maintenance of water and electrolyte balance, functioning of the central nervous system and the cardiovascular system. The availability of cortisol to the glucocorticoid receptor is locally controlled by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). Evidence of changes in intracellular GC metabolism in the pathogenesis of obesity, metabolic syndrome (MetS) and cardiovascular complications highlights the role of selective 11β-HSD1 inhibition in the pharmacotherapy of these diseases. This paper discusses the role of 11β-HSD1 in MetS and its cardiovascular complications and the importance of selective inhibition of 11β-HSD1. |
| first_indexed | 2024-03-09T03:35:20Z |
| format | Article |
| id | doaj.art-3a030a9af9804993abf820107b0a6d39 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T03:35:20Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3a030a9af9804993abf820107b0a6d392023-12-03T14:49:00ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011120619010.3390/jcm1120619011β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular DiseasesDaria Kupczyk0Renata Studzińska1Renata Kołodziejska2Szymon Baumgart3Martyna Modrzejewska4Alina Woźniak5Department of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24, 85-092 Bydgoszcz, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza 2, 85-089 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24, 85-092 Bydgoszcz, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza 2, 85-089 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24, 85-092 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24, 85-092 Bydgoszcz, PolandGlucocorticoids (GCs) belong to the group of steroid hormones. Their representative in humans is cortisol. GCs are involved in most physiological processes of the body and play a significant role in important biological processes, including reproduction, growth, immune responses, metabolism, maintenance of water and electrolyte balance, functioning of the central nervous system and the cardiovascular system. The availability of cortisol to the glucocorticoid receptor is locally controlled by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). Evidence of changes in intracellular GC metabolism in the pathogenesis of obesity, metabolic syndrome (MetS) and cardiovascular complications highlights the role of selective 11β-HSD1 inhibition in the pharmacotherapy of these diseases. This paper discusses the role of 11β-HSD1 in MetS and its cardiovascular complications and the importance of selective inhibition of 11β-HSD1.https://www.mdpi.com/2077-0383/11/20/619011β-hydroxysteroid dehydrogenaseglucocorticoidsmetabolic syndromecardiovascular diseases11β-HSD1 selective inhibitors |
| spellingShingle | Daria Kupczyk Renata Studzińska Renata Kołodziejska Szymon Baumgart Martyna Modrzejewska Alina Woźniak 11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases Journal of Clinical Medicine 11β-hydroxysteroid dehydrogenase glucocorticoids metabolic syndrome cardiovascular diseases 11β-HSD1 selective inhibitors |
| title | 11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases |
| title_full | 11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases |
| title_fullStr | 11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases |
| title_full_unstemmed | 11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases |
| title_short | 11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases |
| title_sort | 11β hydroxysteroid dehydrogenase type 1 as a potential treatment target in cardiovascular diseases |
| topic | 11β-hydroxysteroid dehydrogenase glucocorticoids metabolic syndrome cardiovascular diseases 11β-HSD1 selective inhibitors |
| url | https://www.mdpi.com/2077-0383/11/20/6190 |
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