Medical micro- and nanomotors in the body
Attributed to the miniaturized body size and active mobility, micro- and nanomotors (MNMs) have demonstrated tremendous potential for medical applications. However, from bench to bedside, massive efforts are needed to address critical issues, such as cost-effective fabrication, on-demand integration...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-02-01
|
| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221138352200435X |
| _version_ | 1797897286216318976 |
|---|---|
| author | Huaan Li Fei Peng Xiaohui Yan Chun Mao Xing Ma Daniela A. Wilson Qiang He Yingfeng Tu |
| author_facet | Huaan Li Fei Peng Xiaohui Yan Chun Mao Xing Ma Daniela A. Wilson Qiang He Yingfeng Tu |
| author_sort | Huaan Li |
| collection | DOAJ |
| description | Attributed to the miniaturized body size and active mobility, micro- and nanomotors (MNMs) have demonstrated tremendous potential for medical applications. However, from bench to bedside, massive efforts are needed to address critical issues, such as cost-effective fabrication, on-demand integration of multiple functions, biocompatibility, biodegradability, controlled propulsion and in vivo navigation. Herein, we summarize the advances of biomedical MNMs reported in the past two decades, with particular emphasis on the design, fabrication, propulsion, navigation, and the abilities of biological barriers penetration, biosensing, diagnosis, minimally invasive surgery and targeted cargo delivery. Future perspectives and challenges are discussed as well. This review can lay the foundation for the future direction of medical MNMs, pushing one step forward on the road to achieving practical theranostics using MNMs. |
| first_indexed | 2024-04-10T07:55:04Z |
| format | Article |
| id | doaj.art-3a03e45e743e4ed28e7c89d0dc5086c5 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-04-10T07:55:04Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-3a03e45e743e4ed28e7c89d0dc5086c52023-02-23T04:31:17ZengElsevierActa Pharmaceutica Sinica B2211-38352023-02-01132517541Medical micro- and nanomotors in the bodyHuaan Li0Fei Peng1Xiaohui Yan2Chun Mao3Xing Ma4Daniela A. Wilson5Qiang He6Yingfeng Tu7Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China; School of Pharmaceutical Science, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, ChinaSchool of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China; Corresponding authors. Fax: +86 020 62789590.State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Centre for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China; Corresponding authors. Fax: +86 020 62789590.National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; Corresponding authors. Fax: +86 020 62789590.Sauvage Laboratory for Smart Materials, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China; Corresponding authors. Fax: +86 020 62789590.Institute for Molecules and Materials, Radboud University, Nijmegen, 6525 AJ, the Netherlands; Corresponding authors. Fax: +86 020 62789590.Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), School of Medicine and Health, Harbin Institute of Technology, Harbin 150080, China; Corresponding authors. Fax: +86 020 62789590.Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China; School of Pharmaceutical Science, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China; Corresponding authors. Fax: +86 020 62789590.Attributed to the miniaturized body size and active mobility, micro- and nanomotors (MNMs) have demonstrated tremendous potential for medical applications. However, from bench to bedside, massive efforts are needed to address critical issues, such as cost-effective fabrication, on-demand integration of multiple functions, biocompatibility, biodegradability, controlled propulsion and in vivo navigation. Herein, we summarize the advances of biomedical MNMs reported in the past two decades, with particular emphasis on the design, fabrication, propulsion, navigation, and the abilities of biological barriers penetration, biosensing, diagnosis, minimally invasive surgery and targeted cargo delivery. Future perspectives and challenges are discussed as well. This review can lay the foundation for the future direction of medical MNMs, pushing one step forward on the road to achieving practical theranostics using MNMs.http://www.sciencedirect.com/science/article/pii/S221138352200435XMicro- and nanomotorsFunction integrationControlled propulsionIn vivo navigationBiomedical applicationsMinimally invasive microsurgery |
| spellingShingle | Huaan Li Fei Peng Xiaohui Yan Chun Mao Xing Ma Daniela A. Wilson Qiang He Yingfeng Tu Medical micro- and nanomotors in the body Acta Pharmaceutica Sinica B Micro- and nanomotors Function integration Controlled propulsion In vivo navigation Biomedical applications Minimally invasive microsurgery |
| title | Medical micro- and nanomotors in the body |
| title_full | Medical micro- and nanomotors in the body |
| title_fullStr | Medical micro- and nanomotors in the body |
| title_full_unstemmed | Medical micro- and nanomotors in the body |
| title_short | Medical micro- and nanomotors in the body |
| title_sort | medical micro and nanomotors in the body |
| topic | Micro- and nanomotors Function integration Controlled propulsion In vivo navigation Biomedical applications Minimally invasive microsurgery |
| url | http://www.sciencedirect.com/science/article/pii/S221138352200435X |
| work_keys_str_mv | AT huaanli medicalmicroandnanomotorsinthebody AT feipeng medicalmicroandnanomotorsinthebody AT xiaohuiyan medicalmicroandnanomotorsinthebody AT chunmao medicalmicroandnanomotorsinthebody AT xingma medicalmicroandnanomotorsinthebody AT danielaawilson medicalmicroandnanomotorsinthebody AT qianghe medicalmicroandnanomotorsinthebody AT yingfengtu medicalmicroandnanomotorsinthebody |