Efficacy of Acetylshikonin in Preventing Obesity and Hepatic Steatosis in db/db Mice

Efficacy of Acetylshikonin in Preventing Obesity and Hepatic Steatosis in db/db Mice

Zicao (Lithospermum erythrorhizon) has been used in clinics as a traditional Chinese medicine for thousands of years. Acetylshikonin (AS) is the main ingredient of Zicao, Xinjiang, China. The objective of this study was to investigate the anti-obesity and anti-nonalcoholic fatty liver disease (NAFLD...

Full description

Bibliographic Details
Main Authors:	Mei-Ling Su, Yu He, Qi-Sen Li, Bang-Hao Zhu
Format:	Article
Language:	English
Published:	MDPI AG 2016-07-01
Series:	Molecules
Subjects:	acetylshikonin obesity nonalcoholic fatty liver disease lipid metabolism inflammatory cytokines
Online Access:	http://www.mdpi.com/1420-3049/21/8/976

Similar Items

Electromagnetic Fields Ameliorate Insulin Resistance and Hepatic Steatosis by Modulating Redox Homeostasis and SREBP-1c Expression in db/db Mice
by: Zhai M, et al.
Published: (2021-03-01)

Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation
by: Ming Hong, et al.
Published: (2019-11-01)

Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice
by: Panshuang Qiao, et al.
Published: (2022-08-01)

Accuracy of attenuation imaging in the assessment of pediatric hepatic steatosis: correlation with the controlled attenuation parameter
by: Pyeong Hwa Kim, et al.
Published: (2022-10-01)

Acetylshikonin inhibits the migration and invasion of A375 cells by reversing EMT process via the PI3K/Akt/mTOR pathway
by: Shuang Jiang, et al.
Published: (2019-01-01)

Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice
by: Haeng Jeon Hur, et al.
Published: (2020-10-01)

Modifications decrease hepatic steatosis in Taiwanese with metabolic‐associated fatty liver disease
by: Tso‐Tsai Liu, et al.
Published: (2022-10-01)

The aqueous extract of Phragmites rhizome improves hepatic steatosis in obese mice via the AMPK-mediated inhibition of ER stress
by: Tae Woo Jung, et al.
Published: (2022-08-01)

Inter-platform reproducibility of ultrasound-based fat fraction for evaluating hepatic steatosis in nonalcoholic fatty liver disease
by: Sun Kyung Jeon, et al.
Published: (2024-02-01)

Examining genetic associations with hepatic steatosis in Mexican-origin adults
by: Mario Jesus Trejo, et al.
Published: (2023-09-01)

Traditional Chinese Medicine formula Dai-Zong-Fang alleviating hepatic steatosis in db/db mice via gut microbiota modulation
by: Li-Wei Zhang, et al.
Published: (2024-01-01)

Stevia and Stevioside Attenuate Liver Steatosis through PPARα-Mediated Lipophagy in <i>db/db</i> Mice Hepatocytes
by: Miey Park, et al.
Published: (2022-12-01)

Honokiol Improves Liver Steatosis in Ovariectomized Mice
by: Yeon-Hui Jeong, et al.
Published: (2018-01-01)

Update on Imaging-based Noninvasive Methods for Assessing Hepatic Steatosis in Nonalcoholic Fatty Liver Disease
by: Chia-Chien Kang, et al.
Published: (2024-04-01)

How many times should we repeat measurements of the ultrasound-guided attenuation parameter for evaluating hepatic steatosis?
by: Duck Min Seo, et al.
Published: (2023-04-01)

Cytokines and inflammatory markers in nonalcoholic fatty liver disease: A narrative review
by: Sujal Patel, et al.
Published: (2023-01-01)

Genome-Wide Identification of <i>LeBAHDs</i> in <i>Lithospermum erythrorhizon</i> and In Vivo Transgenic Studies Confirm the Critical Roles of <i>LeBAHD1/LeSAT1</i> in the Conversion of Shikonin to Acetylshikonin
by: Xuan Wang, et al.
Published: (2022-11-01)

Comparison between obese and non-obese nonalcoholic fatty liver disease
by: Wah-Kheong Chan
Published: (2023-02-01)

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development
by: Nadia Boudaba, et al.
Published: (2018-02-01)

Hepatic overexpression of protein targeting to glycogen attenuates obesity and improves hyperglycemia in db/db mice
by: Iliana López-Soldado, et al.
Published: (2022-09-01)

Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan
by: Mahsa Miryan, et al.
Published: (2024-04-01)

Lean vs. obese phenotypes of nonalcoholic fatty liver disease: similar or different?
by: Ho Soo Chun, et al.
Published: (2023-04-01)

Hepatic Steatosis Index in the Detection of Fatty Liver in Patients with Chronic Hepatitis B Receiving Antiviral Therapy
by: Jin Won Chang, et al.
Published: (2021-01-01)

Obesity and nonalcoholic fatty liver disease: metabolic risks and their correction
by: Kseniya Andreevna Komshilova, et al.
Published: (2015-08-01)

Ultrasound Stratification of Hepatic Steatosis Using Hepatorenal Index
by: Stephen I. Johnson, et al.
Published: (2021-08-01)

Sex-Dependent Effects of Eicosapentaenoic Acid on Hepatic Steatosis in UCP1 Knockout Mice
by: Kembra Albracht-Schulte, et al.
Published: (2021-10-01)

The relationship between Lipocalin-2 level and hepatic steatosis in obese patients with NAFLD after bariatric surgery
by: Jiaqi Chen, et al.
Published: (2022-01-01)

Fatty Liver, and Not Visceral Fat, Is More Associated with Liver Fibrosis and Diabetes in Non-Obese Japanese Individuals: A Cross-Sectional Study
by: Noriyo Urata, et al.
Published: (2020-09-01)

Wilson disease diagnosed incidentally by targeted gene panel sequencing in a Korean boy with severe obesity
by: Minji Im, et al.
Published: (2022-09-01)

Noninvasive serum biomarkers for liver steatosis in nonalcoholic fatty liver disease: Current and future developments
by: Sang Bong Ahn
Published: (2023-02-01)

Circulating Levels of Pro-Neurotensin and Its Relationship with Nonalcoholic Steatohepatitis and Hepatic Lipid Metabolism
by: Beatriz Villar, et al.
Published: (2021-06-01)

Correlational study of nonalcoholic fatty liver disease diagnosed by ultrasonography with lipid profile and body mass index in adult nepalese population
by: Umesh P Khanal, et al.
Published: (2019-01-01)

Hepatic steatosis in women with polycystic ovary syndrome
by: Xinyu Hong, et al.
Published: (2023-09-01)

Similar insulin regulation of splanchnic FFA and VLDL-TG in men with nonalcoholic hepatic steatosis and steatohepatitis
by: Jeyanthini Risikesan, et al.
Published: (2024-07-01)

1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice
by: Qingpu Liu, et al.
Published: (2016-02-01)

Effects of probiotics combined with dietary and lifestyle modification on clinical, biochemical, and radiological parameters in obese children with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis: a randomized clinical trial
by: Thushara Rodrigo, et al.
Published: (2022-06-01)

Malnutrition and inflammation status in nonobese patients with inflammatory bowel disease are associated with nonalcoholic fatty liver disease: a retrospective study
by: Takahiro Nagata, et al.
Published: (2023-10-01)

Polyphenolic extract of lotus root (edible rhizome of <it>Nelumbo nucifera</it>) alleviates hepatic steatosis in obese diabetic <it>db/db </it>mice
by: Tsuruta Yumi, et al.
Published: (2011-11-01)

Acetaminophen-Induced Hepatotoxicity in Obesity and Nonalcoholic Fatty Liver Disease: A Critical Review
by: Karima Begriche, et al.
Published: (2023-01-01)

Nonalcoholic fatty liver disease: Noninvasive methods of diagnosing hepatic steatosis
by: Rasha AlShaalan, et al.
Published: (2015-01-01)