The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in rats
Abstract Background Given the difficulties or incapacity of teeth movement in orthodontic treatment, the ways to speed tooth movement must be investigated. Besides, nonsteroidal anti-inflammatory drugs (NSAIDs) were utilized to treat pain caused by tooth movement during orthodontic treatment. The pu...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-023-03359-3 |
| _version_ | 1797451259413790720 |
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| author | Jiao Xin Xinxin Zhan Fu Zheng Huazhi Li Yixiang Wang Cuiying Li Jiuhui Jiang |
| author_facet | Jiao Xin Xinxin Zhan Fu Zheng Huazhi Li Yixiang Wang Cuiying Li Jiuhui Jiang |
| author_sort | Jiao Xin |
| collection | DOAJ |
| description | Abstract Background Given the difficulties or incapacity of teeth movement in orthodontic treatment, the ways to speed tooth movement must be investigated. Besides, nonsteroidal anti-inflammatory drugs (NSAIDs) were utilized to treat pain caused by tooth movement during orthodontic treatment. The purpose of this study is to examine the impact of aspirin and low-frequency high-intensity ultrasound (LFHIU) on rat orthodontic tooth movement in rats. Methods Thirty-six male Sprague-Dawley rats were divided into three groups: orthodontic (O), ultrasound-treated orthodontic (OU), and ultrasound-treated orthodontic with aspirin gavage (OUA) group. In the OU and OUA group, LFHIU (44 W/cm2, 28 kHz) was applied to the buccal side of the maxillary first molar alveolar bone for 10 s every day. In the OUA group, aspirin was given by gavage every day. The rats were sacrificed on days 1, 3, 7, and 14. Results After ultrasonic treatment, the speed of tooth movement was increased by about 1.5 times. And the number of osteoclasts considerably increased by about 2 times. However, they decreased slightly after aspirin gavage. By Applying ultrasound therapy, Receptor Activator for Nuclear Factor-κ B Ligand (RANKL) levels in periodontal tissue were elevated. Aspirin was able to reduce these increases. Results from Micro Computed Tomography (Micro-CT) revealed that bone mineral density decreased by about 1/5 after ultrasound treatment on the compression side. The rate of bone mineral apposition indicated that bone was forming under tension, and that of the OU group increased by about 1.3 times that O group. Conclusions Although aspirin slowed this trend, LFHIU still enhanced overall tooth mobility in orthodontic treatment. |
| first_indexed | 2024-03-09T14:52:08Z |
| format | Article |
| id | doaj.art-3a05d140fda14a159690b9569777ad38 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-03-09T14:52:08Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-3a05d140fda14a159690b9569777ad382023-11-26T14:25:03ZengBMCBMC Oral Health1472-68312023-09-012311910.1186/s12903-023-03359-3The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in ratsJiao Xin0Xinxin Zhan1Fu Zheng2Huazhi Li3Yixiang Wang4Cuiying Li5Jiuhui Jiang6Central Laboratory, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesCentral Laboratory, Department of Oral and Maxillofacial Surgery, Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University SchoolCentral Laboratory, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesAbstract Background Given the difficulties or incapacity of teeth movement in orthodontic treatment, the ways to speed tooth movement must be investigated. Besides, nonsteroidal anti-inflammatory drugs (NSAIDs) were utilized to treat pain caused by tooth movement during orthodontic treatment. The purpose of this study is to examine the impact of aspirin and low-frequency high-intensity ultrasound (LFHIU) on rat orthodontic tooth movement in rats. Methods Thirty-six male Sprague-Dawley rats were divided into three groups: orthodontic (O), ultrasound-treated orthodontic (OU), and ultrasound-treated orthodontic with aspirin gavage (OUA) group. In the OU and OUA group, LFHIU (44 W/cm2, 28 kHz) was applied to the buccal side of the maxillary first molar alveolar bone for 10 s every day. In the OUA group, aspirin was given by gavage every day. The rats were sacrificed on days 1, 3, 7, and 14. Results After ultrasonic treatment, the speed of tooth movement was increased by about 1.5 times. And the number of osteoclasts considerably increased by about 2 times. However, they decreased slightly after aspirin gavage. By Applying ultrasound therapy, Receptor Activator for Nuclear Factor-κ B Ligand (RANKL) levels in periodontal tissue were elevated. Aspirin was able to reduce these increases. Results from Micro Computed Tomography (Micro-CT) revealed that bone mineral density decreased by about 1/5 after ultrasound treatment on the compression side. The rate of bone mineral apposition indicated that bone was forming under tension, and that of the OU group increased by about 1.3 times that O group. Conclusions Although aspirin slowed this trend, LFHIU still enhanced overall tooth mobility in orthodontic treatment.https://doi.org/10.1186/s12903-023-03359-3AspirinOrthodonticTooth movementUltrasound |
| spellingShingle | Jiao Xin Xinxin Zhan Fu Zheng Huazhi Li Yixiang Wang Cuiying Li Jiuhui Jiang The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in rats BMC Oral Health Aspirin Orthodontic Tooth movement Ultrasound |
| title | The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in rats |
| title_full | The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in rats |
| title_fullStr | The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in rats |
| title_full_unstemmed | The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in rats |
| title_short | The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in rats |
| title_sort | effect of low frequency high intensity ultrasound combined with aspirin on tooth movement in rats |
| topic | Aspirin Orthodontic Tooth movement Ultrasound |
| url | https://doi.org/10.1186/s12903-023-03359-3 |
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