Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine
In recent years, the incidence of different types of cancer and patient survival have been rising, as well as their prevalence. The increase in survival in recent years exposes the patients to a set of stressful factors such as more rigorous follow-up and more aggressive therapeutic regimens that, a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.956923/full |
| _version_ | 1811260976264118272 |
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| author | Oscar Fraile-Martinez Oscar Fraile-Martinez Miguel A. Alvarez-Mon Miguel A. Alvarez-Mon Miguel A. Alvarez-Mon Cielo Garcia-Montero Cielo Garcia-Montero Leonel Pekarek Leonel Pekarek Leonel Pekarek Luis G. Guijarro Luis G. Guijarro Guillermo Lahera Guillermo Lahera Guillermo Lahera Miguel A. Saez Miguel A. Saez Miguel A. Saez Jorge Monserrat Jorge Monserrat Domitila Motogo Javier Quintero Javier Quintero Melchor Alvarez-Mon Melchor Alvarez-Mon Melchor Alvarez-Mon Miguel A. Ortega Miguel A. Ortega Miguel A. Ortega |
| author_facet | Oscar Fraile-Martinez Oscar Fraile-Martinez Miguel A. Alvarez-Mon Miguel A. Alvarez-Mon Miguel A. Alvarez-Mon Cielo Garcia-Montero Cielo Garcia-Montero Leonel Pekarek Leonel Pekarek Leonel Pekarek Luis G. Guijarro Luis G. Guijarro Guillermo Lahera Guillermo Lahera Guillermo Lahera Miguel A. Saez Miguel A. Saez Miguel A. Saez Jorge Monserrat Jorge Monserrat Domitila Motogo Javier Quintero Javier Quintero Melchor Alvarez-Mon Melchor Alvarez-Mon Melchor Alvarez-Mon Miguel A. Ortega Miguel A. Ortega Miguel A. Ortega |
| author_sort | Oscar Fraile-Martinez |
| collection | DOAJ |
| description | In recent years, the incidence of different types of cancer and patient survival have been rising, as well as their prevalence. The increase in survival in recent years exposes the patients to a set of stressful factors such as more rigorous follow-up and more aggressive therapeutic regimens that, added to the diagnosis of the disease itself, cause an increase in the incidence of depressive disorders. These alterations have important consequences for the patients, reducing their average survival and quality of life, and for these reasons, special emphasis has been placed on developing numerous screening tests and early recognition of depressive symptoms. Despite that cancer and major depressive disorder are complex and heterogeneous entities, they also share many critical pathophysiological mechanisms, aiding to explain this complex relationship from a biological perspective. Moreover, a growing body of evidence is supporting the relevant role of lifestyle habits in the prevention and management of both depression and cancer. Therefore, the present study aims to perform a thorough review of the intricate relationship between depression and cancer, with a special focus on its biological links, clinical management, challenges, and the central role of lifestyle medicine as adjunctive and preventive approaches to improve the quality of life of these patients. |
| first_indexed | 2024-04-12T18:55:34Z |
| format | Article |
| id | doaj.art-3a065979576e45c5bba32bb7f2954490 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T18:55:34Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3a065979576e45c5bba32bb7f29544902022-12-22T03:20:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.956923956923Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicineOscar Fraile-Martinez0Oscar Fraile-Martinez1Miguel A. Alvarez-Mon2Miguel A. Alvarez-Mon3Miguel A. Alvarez-Mon4Cielo Garcia-Montero5Cielo Garcia-Montero6Leonel Pekarek7Leonel Pekarek8Leonel Pekarek9Luis G. Guijarro10Luis G. Guijarro11Guillermo Lahera12Guillermo Lahera13Guillermo Lahera14Miguel A. Saez15Miguel A. Saez16Miguel A. Saez17Jorge Monserrat18Jorge Monserrat19Domitila Motogo20Javier Quintero21Javier Quintero22Melchor Alvarez-Mon23Melchor Alvarez-Mon24Melchor Alvarez-Mon25Miguel A. Ortega26Miguel A. Ortega27Miguel A. Ortega28Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, SpainDepartment of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, SpainOncology Service, Guadalajara University Hospital, Guadalajara, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, SpainUnit of Biochemistry and Molecular Biology, Department of System Biology, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), University of Alcalá, Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, SpainPsychiatry Service, Center for Biomedical Research in the Mental Health Network, University Hospital Príncipe de Asturias Centro de Investigación Biomédica en Red en el Área temática de Salud Mental (CIBERSAM), Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, SpainPathological Anatomy Service, Central University Hospital of Defence-UAH Madrid, Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, SpainDepartment of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, Madrid, SpainDepartment of Legal Medicine and Psychiatry, Complutense University, Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, SpainImmune System Diseases-Rheumatology, Oncology Service an Internal Medicine, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), University Hospital Príncipe de Asturias, Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain0Cancer Registry and Pathology Department, Principe de Asturias University Hospital, Alcala de Henares, SpainIn recent years, the incidence of different types of cancer and patient survival have been rising, as well as their prevalence. The increase in survival in recent years exposes the patients to a set of stressful factors such as more rigorous follow-up and more aggressive therapeutic regimens that, added to the diagnosis of the disease itself, cause an increase in the incidence of depressive disorders. These alterations have important consequences for the patients, reducing their average survival and quality of life, and for these reasons, special emphasis has been placed on developing numerous screening tests and early recognition of depressive symptoms. Despite that cancer and major depressive disorder are complex and heterogeneous entities, they also share many critical pathophysiological mechanisms, aiding to explain this complex relationship from a biological perspective. Moreover, a growing body of evidence is supporting the relevant role of lifestyle habits in the prevention and management of both depression and cancer. Therefore, the present study aims to perform a thorough review of the intricate relationship between depression and cancer, with a special focus on its biological links, clinical management, challenges, and the central role of lifestyle medicine as adjunctive and preventive approaches to improve the quality of life of these patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.956923/fullcancerdepressionlifestyle medicinemultidisciplinary approachesclinical challengesTranslational medicine |
| spellingShingle | Oscar Fraile-Martinez Oscar Fraile-Martinez Miguel A. Alvarez-Mon Miguel A. Alvarez-Mon Miguel A. Alvarez-Mon Cielo Garcia-Montero Cielo Garcia-Montero Leonel Pekarek Leonel Pekarek Leonel Pekarek Luis G. Guijarro Luis G. Guijarro Guillermo Lahera Guillermo Lahera Guillermo Lahera Miguel A. Saez Miguel A. Saez Miguel A. Saez Jorge Monserrat Jorge Monserrat Domitila Motogo Javier Quintero Javier Quintero Melchor Alvarez-Mon Melchor Alvarez-Mon Melchor Alvarez-Mon Miguel A. Ortega Miguel A. Ortega Miguel A. Ortega Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine Frontiers in Oncology cancer depression lifestyle medicine multidisciplinary approaches clinical challenges Translational medicine |
| title | Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine |
| title_full | Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine |
| title_fullStr | Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine |
| title_full_unstemmed | Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine |
| title_short | Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine |
| title_sort | understanding the basis of major depressive disorder in oncological patients biological links clinical management challenges and lifestyle medicine |
| topic | cancer depression lifestyle medicine multidisciplinary approaches clinical challenges Translational medicine |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.956923/full |
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