Defects in GnRH Neuron Migration/Development and Hypothalamic-Pituitary Signaling Impact Clinical Variability of Kallmann Syndrome

Defects in GnRH Neuron Migration/Development and Hypothalamic-Pituitary Signaling Impact Clinical Variability of Kallmann Syndrome

Kallmann syndrome (KS) is a combination of isolated hypogonadotropic hypogonadism (IHH) with olfactory dysfunction, representing a heterogeneous disorder with a broad phenotypic spectrum. The genetic background of KS has not yet been fully established. This study was conducted on 46 Polish KS subjec...

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Bibliographic Details
Main Authors: Małgorzata Kałużna, Bartłomiej Budny, Michał Rabijewski, Jarosław Kałużny, Agnieszka Dubiel, Małgorzata Trofimiuk-Müldner, Elżbieta Wrotkowska, Alicja Hubalewska-Dydejczyk, Marek Ruchała, Katarzyna Ziemnicka
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Genes
Subjects:
Kallmann syndrome (KS)
isolated hypogonadotropic hypogonadism (IHH)
next-generation sequencing (NGS)
combined pituitary hormone deficiency (CPHD)
GnRH neuron
anosmia
Online Access:https://www.mdpi.com/2073-4425/12/6/868

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