Human Norovirus: Experimental Models of Infection
Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. HuNoV infections lead to substantial societal and economic burdens. There are currently no licensed vaccines or therapeutics for the prevention or treatment of HuNoVs. A lack of well-characterized <i>in vitro<...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/11/2/151 |
| _version_ | 1818993599911559168 |
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| author | Kyle V. Todd Ralph A. Tripp |
| author_facet | Kyle V. Todd Ralph A. Tripp |
| author_sort | Kyle V. Todd |
| collection | DOAJ |
| description | Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. HuNoV infections lead to substantial societal and economic burdens. There are currently no licensed vaccines or therapeutics for the prevention or treatment of HuNoVs. A lack of well-characterized <i>in vitro</i> and <i>in vivo</i> infection models has limited the development of HuNoV countermeasures. Experimental infection of human volunteers and the use of related viruses such as murine NoV have provided helpful insights into HuNoV biology and vaccine and therapeutic development. There remains a need for robust animal models and reverse genetic systems to further HuNoV research. This review summarizes available HuNoV animal models and reverse genetic systems, while providing insight into their usefulness for vaccine and therapeutic development. |
| first_indexed | 2024-12-20T20:44:37Z |
| format | Article |
| id | doaj.art-3a07f23d06494112aad6690558495056 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-20T20:44:37Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-3a07f23d06494112aad66905584950562022-12-21T19:27:05ZengMDPI AGViruses1999-49152019-02-0111215110.3390/v11020151v11020151Human Norovirus: Experimental Models of InfectionKyle V. Todd0Ralph A. Tripp1Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USADepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USAHuman noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. HuNoV infections lead to substantial societal and economic burdens. There are currently no licensed vaccines or therapeutics for the prevention or treatment of HuNoVs. A lack of well-characterized <i>in vitro</i> and <i>in vivo</i> infection models has limited the development of HuNoV countermeasures. Experimental infection of human volunteers and the use of related viruses such as murine NoV have provided helpful insights into HuNoV biology and vaccine and therapeutic development. There remains a need for robust animal models and reverse genetic systems to further HuNoV research. This review summarizes available HuNoV animal models and reverse genetic systems, while providing insight into their usefulness for vaccine and therapeutic development.https://www.mdpi.com/1999-4915/11/2/151norovirushuman norovirusanimal modelsreverse geneticsvaccine development |
| spellingShingle | Kyle V. Todd Ralph A. Tripp Human Norovirus: Experimental Models of Infection Viruses norovirus human norovirus animal models reverse genetics vaccine development |
| title | Human Norovirus: Experimental Models of Infection |
| title_full | Human Norovirus: Experimental Models of Infection |
| title_fullStr | Human Norovirus: Experimental Models of Infection |
| title_full_unstemmed | Human Norovirus: Experimental Models of Infection |
| title_short | Human Norovirus: Experimental Models of Infection |
| title_sort | human norovirus experimental models of infection |
| topic | norovirus human norovirus animal models reverse genetics vaccine development |
| url | https://www.mdpi.com/1999-4915/11/2/151 |
| work_keys_str_mv | AT kylevtodd humannorovirusexperimentalmodelsofinfection AT ralphatripp humannorovirusexperimentalmodelsofinfection |