Design and analysis of a Petri net model of the Von Hippel-Lindau (VHL) tumor suppressor interaction network.
Von Hippel-Lindau (VHL) syndrome is a hereditary condition predisposing to the development of different cancer forms, related to germline inactivation of the homonymous tumor suppressor pVHL. The best characterized function of pVHL is the ubiquitination dependent degradation of Hypoxia Inducible Fac...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4041725?pdf=render |
| _version_ | 1828528044801785856 |
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| author | Giovanni Minervini Elisabetta Panizzoni Manuel Giollo Alessandro Masiero Carlo Ferrari Silvio C E Tosatto |
| author_facet | Giovanni Minervini Elisabetta Panizzoni Manuel Giollo Alessandro Masiero Carlo Ferrari Silvio C E Tosatto |
| author_sort | Giovanni Minervini |
| collection | DOAJ |
| description | Von Hippel-Lindau (VHL) syndrome is a hereditary condition predisposing to the development of different cancer forms, related to germline inactivation of the homonymous tumor suppressor pVHL. The best characterized function of pVHL is the ubiquitination dependent degradation of Hypoxia Inducible Factor (HIF) via the proteasome. It is also involved in several cellular pathways acting as a molecular hub and interacting with more than 200 different proteins. Molecular details of pVHL plasticity remain in large part unknown. Here, we present a novel manually curated Petri Net (PN) model of the main pVHL functional pathways. The model was built using functional information derived from the literature. It includes all major pVHL functions and is able to credibly reproduce VHL syndrome at the molecular level. The reliability of the PN model also allowed in silico knockout experiments, driven by previous model analysis. Interestingly, PN analysis suggests that the variability of different VHL manifestations is correlated with the concomitant inactivation of different metabolic pathways. |
| first_indexed | 2024-12-11T21:47:45Z |
| format | Article |
| id | doaj.art-3a0e46a2cfa1443699aac52dfb9bc19e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T21:47:45Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3a0e46a2cfa1443699aac52dfb9bc19e2022-12-22T00:49:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9698610.1371/journal.pone.0096986Design and analysis of a Petri net model of the Von Hippel-Lindau (VHL) tumor suppressor interaction network.Giovanni MinerviniElisabetta PanizzoniManuel GiolloAlessandro MasieroCarlo FerrariSilvio C E TosattoVon Hippel-Lindau (VHL) syndrome is a hereditary condition predisposing to the development of different cancer forms, related to germline inactivation of the homonymous tumor suppressor pVHL. The best characterized function of pVHL is the ubiquitination dependent degradation of Hypoxia Inducible Factor (HIF) via the proteasome. It is also involved in several cellular pathways acting as a molecular hub and interacting with more than 200 different proteins. Molecular details of pVHL plasticity remain in large part unknown. Here, we present a novel manually curated Petri Net (PN) model of the main pVHL functional pathways. The model was built using functional information derived from the literature. It includes all major pVHL functions and is able to credibly reproduce VHL syndrome at the molecular level. The reliability of the PN model also allowed in silico knockout experiments, driven by previous model analysis. Interestingly, PN analysis suggests that the variability of different VHL manifestations is correlated with the concomitant inactivation of different metabolic pathways.http://europepmc.org/articles/PMC4041725?pdf=render |
| spellingShingle | Giovanni Minervini Elisabetta Panizzoni Manuel Giollo Alessandro Masiero Carlo Ferrari Silvio C E Tosatto Design and analysis of a Petri net model of the Von Hippel-Lindau (VHL) tumor suppressor interaction network. PLoS ONE |
| title | Design and analysis of a Petri net model of the Von Hippel-Lindau (VHL) tumor suppressor interaction network. |
| title_full | Design and analysis of a Petri net model of the Von Hippel-Lindau (VHL) tumor suppressor interaction network. |
| title_fullStr | Design and analysis of a Petri net model of the Von Hippel-Lindau (VHL) tumor suppressor interaction network. |
| title_full_unstemmed | Design and analysis of a Petri net model of the Von Hippel-Lindau (VHL) tumor suppressor interaction network. |
| title_short | Design and analysis of a Petri net model of the Von Hippel-Lindau (VHL) tumor suppressor interaction network. |
| title_sort | design and analysis of a petri net model of the von hippel lindau vhl tumor suppressor interaction network |
| url | http://europepmc.org/articles/PMC4041725?pdf=render |
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