RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer

RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer

The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor RXFP1 with functi...

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Bibliographic Details
Main Authors: Thatchawan eThanasupawat, Aleksandra eGlogowska, Maxwell eBurg, William G. Wong, Cuong eHoang-Vu, Sabine eHombach-Klonisch, Thomas eKlonisch
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Endocrinology
Subjects:
Cancer
brain tumor
RXFP1
CTRP8
C1q/TNF-related proteins
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00127/full
Description
Summary:The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor RXFP1 with functions in brain cancer. Here we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.
ISSN:1664-2392

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