Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice

Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice

Summary: Ionizing radiation (IR) is a risk factor for acute myeloid leukemia (rAML). Murine rAMLs feature both hemizygous chromosome 2 deletions (Del2) and point mutations (R235) within the hematopoietic regulatory gene Spi1. We generated a heterozygous CBA Spi1 R235 mouse (CBASpm/+) which develops...

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Bibliographic Details
Main Authors: Natalie Brown, Rosemary Finnon, Paul Finnon, Roisin McCarron, Lourdes Cruz-Garcia, Grainne O’Brien, Eleanor Herbert, Cheryl L. Scudamore, Edouard Morel, Christophe Badie
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Cancer
Genetics
Molecular Genetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223016073

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