t-PA Suppresses the Immune Response and Aggravates Neurological Deficit in a Murine Model of Ischemic Stroke

t-PA Suppresses the Immune Response and Aggravates Neurological Deficit in a Murine Model of Ischemic Stroke

Introduction: Acute ischemic stroke (AIS) is a potent trigger of immunosuppression, resulting in increased infection risk. While thrombolytic therapy with tissue-type plasminogen activator (t-PA) is still the only pharmacological treatment for AIS, plasmin, the effector protease, has been reported t...

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Bibliographic Details
Main Authors: Dominik F. Draxler, Felix Lee, Heidi Ho, Charithani B. Keragala, Robert L. Medcalf, Be'eri Niego
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
stroke
MCAo
t-PA
plasminogen
immune system
immunosuppression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00591/full

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