High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice

A metagenomic analysis reveals that male and female mice exhibit sex-dependent responses to a high-fat diet (HFD), and that estrogenic ligands can attenuate certain aspects of HFDinduced dysbiosis.

Bibliographic Details
Main Authors: Linnea Hases, Lina Stepanauskaite, Madeleine Birgersson, Nele Brusselaers, Ina Schuppe-Koistinen, Amena Archer, Lars Engstrand, Cecilia Williams
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04406-5
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author Linnea Hases
Lina Stepanauskaite
Madeleine Birgersson
Nele Brusselaers
Ina Schuppe-Koistinen
Amena Archer
Lars Engstrand
Cecilia Williams
author_facet Linnea Hases
Lina Stepanauskaite
Madeleine Birgersson
Nele Brusselaers
Ina Schuppe-Koistinen
Amena Archer
Lars Engstrand
Cecilia Williams
author_sort Linnea Hases
collection DOAJ
description A metagenomic analysis reveals that male and female mice exhibit sex-dependent responses to a high-fat diet (HFD), and that estrogenic ligands can attenuate certain aspects of HFDinduced dysbiosis.
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spelling doaj.art-3a1403a1393f4fdbaf958e75f5ebbdec2023-01-15T12:18:40ZengNature PortfolioCommunications Biology2399-36422023-01-016111210.1038/s42003-022-04406-5High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in miceLinnea Hases0Lina Stepanauskaite1Madeleine Birgersson2Nele Brusselaers3Ina Schuppe-Koistinen4Amena Archer5Lars Engstrand6Cecilia Williams7Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of TechnologyScience for Life Laboratory, Department of Protein Science, KTH Royal Institute of TechnologyScience for Life Laboratory, Department of Protein Science, KTH Royal Institute of TechnologyCentre for Translational Microbiome Research, Department of Microbiology, Tumor & Cell Biology, Karolinska Institute, Science for Life LaboratoryCentre for Translational Microbiome Research, Department of Microbiology, Tumor & Cell Biology, Karolinska Institute, Science for Life LaboratoryScience for Life Laboratory, Department of Protein Science, KTH Royal Institute of TechnologyCentre for Translational Microbiome Research, Department of Microbiology, Tumor & Cell Biology, Karolinska Institute, Science for Life LaboratoryScience for Life Laboratory, Department of Protein Science, KTH Royal Institute of TechnologyA metagenomic analysis reveals that male and female mice exhibit sex-dependent responses to a high-fat diet (HFD), and that estrogenic ligands can attenuate certain aspects of HFDinduced dysbiosis.https://doi.org/10.1038/s42003-022-04406-5
spellingShingle Linnea Hases
Lina Stepanauskaite
Madeleine Birgersson
Nele Brusselaers
Ina Schuppe-Koistinen
Amena Archer
Lars Engstrand
Cecilia Williams
High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice
Communications Biology
title High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice
title_full High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice
title_fullStr High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice
title_full_unstemmed High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice
title_short High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice
title_sort high fat diet and estrogen modulate the gut microbiota in a sex dependent manner in mice
url https://doi.org/10.1038/s42003-022-04406-5
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