Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge
Although immune checkpoint inhibitors (ICIs) have dramatically revolutionized the field of oncology over the last decade, severe immune-related adverse events (irAEs) are potentially life-threatening. In comparison with toxicities involving the skin, gastrointestinal tract and endocrine system, neph...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1014257/full |
| _version_ | 1797980073326804992 |
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| author | Martina Catalano Giandomenico Roviello Ilaria Camilla Galli Raffaella Santi Gabriella Nesi |
| author_facet | Martina Catalano Giandomenico Roviello Ilaria Camilla Galli Raffaella Santi Gabriella Nesi |
| author_sort | Martina Catalano |
| collection | DOAJ |
| description | Although immune checkpoint inhibitors (ICIs) have dramatically revolutionized the field of oncology over the last decade, severe immune-related adverse events (irAEs) are potentially life-threatening. In comparison with toxicities involving the skin, gastrointestinal tract and endocrine system, nephrotoxicity is less common but often underestimated due to difficult diagnosis. Management usually consists of treatment discontinuation and/or corticosteroid use. In this review, we summarize current knowledge of ICI-induced nephrotoxicity, evaluating drawbacks and future perspectives. |
| first_indexed | 2024-04-11T05:48:36Z |
| format | Article |
| id | doaj.art-3a15a34b59e34917929f204982de56f9 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T05:48:36Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-3a15a34b59e34917929f204982de56f92022-12-22T04:42:08ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-12-01910.3389/fmed.2022.10142571014257Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challengeMartina Catalano0Giandomenico Roviello1Ilaria Camilla Galli2Raffaella Santi3Gabriella Nesi4School of Human Health Sciences, University of Florence, Florence, ItalyDepartment of Health Sciences, University of Florence, Florence, ItalyHistopathology and Molecular Diagnostics, Careggi Teaching Hospital, Florence, ItalyDepartment of Health Sciences, University of Florence, Florence, ItalyHistopathology and Molecular Diagnostics, Careggi Teaching Hospital, Florence, ItalyAlthough immune checkpoint inhibitors (ICIs) have dramatically revolutionized the field of oncology over the last decade, severe immune-related adverse events (irAEs) are potentially life-threatening. In comparison with toxicities involving the skin, gastrointestinal tract and endocrine system, nephrotoxicity is less common but often underestimated due to difficult diagnosis. Management usually consists of treatment discontinuation and/or corticosteroid use. In this review, we summarize current knowledge of ICI-induced nephrotoxicity, evaluating drawbacks and future perspectives.https://www.frontiersin.org/articles/10.3389/fmed.2022.1014257/fullimmune checkpoint inhibitorsimmune-related adverse eventsnephrotoxicityICI-induced acute kidney injurymultidisciplinary management |
| spellingShingle | Martina Catalano Giandomenico Roviello Ilaria Camilla Galli Raffaella Santi Gabriella Nesi Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge Frontiers in Medicine immune checkpoint inhibitors immune-related adverse events nephrotoxicity ICI-induced acute kidney injury multidisciplinary management |
| title | Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge |
| title_full | Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge |
| title_fullStr | Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge |
| title_full_unstemmed | Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge |
| title_short | Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge |
| title_sort | immune checkpoint inhibitor induced nephrotoxicity an ongoing challenge |
| topic | immune checkpoint inhibitors immune-related adverse events nephrotoxicity ICI-induced acute kidney injury multidisciplinary management |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1014257/full |
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