Age-related differences in integrin expression in peripheral blood lymphocytes
<p>Abstract</p> <p>Alpha integrins play an important role in cell to cell and cell to extra-cellular matrix interactions required for an effective T-lymphocyte-mediated immune response, however little is known about age related differences in expression of alpha integrins on T-cell...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-04-01
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| Series: | Immunity & Ageing |
| Online Access: | http://www.immunityageing.com/content/7/1/5 |
| _version_ | 1811243950655143936 |
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| author | Crooks Christine V Cross Martin L Wall Clare R |
| author_facet | Crooks Christine V Cross Martin L Wall Clare R |
| author_sort | Crooks Christine V |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Alpha integrins play an important role in cell to cell and cell to extra-cellular matrix interactions required for an effective T-lymphocyte-mediated immune response, however little is known about age related differences in expression of alpha integrins on T-cells in humans. We here measured alpha-4 (α4) integrin (CD49d) expression on T-lymphocytes via peripheral blood sampling, comparing parameters between cohorts of young and old adults. No age-related differences were found for the absolute numbers of T-cells, although the percentage of CD4+ T-cells in older adults was significantly greater and the percentage of CD8+ T-cells lower than in younger cohorts. Percentage and absolute numbers of CD3+ T-cells co-expressing CD49d were significantly lower in older adults compared to younger cohorts, and the percentage of gated CD4+ and CD8+ cells that co-labelled positively for CD49d was also reduced in this group. There were no age-related differences in circulating levels of cytokines (Type I interferons) that are known to regulate cell surface integrin expression. Reduced expression of alpha integrins on T-cells may be an early indicator of the loss of homeostatic control that occurs with ageing, contributing to diminished effector T-cell responses during senescence.</p> |
| first_indexed | 2024-04-12T14:16:18Z |
| format | Article |
| id | doaj.art-3a15b3c23a314e9a8715dd3dd3d16f9c |
| institution | Directory Open Access Journal |
| issn | 1742-4933 |
| language | English |
| last_indexed | 2024-04-12T14:16:18Z |
| publishDate | 2010-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Immunity & Ageing |
| spelling | doaj.art-3a15b3c23a314e9a8715dd3dd3d16f9c2022-12-22T03:29:42ZengBMCImmunity & Ageing1742-49332010-04-0171510.1186/1742-4933-7-5Age-related differences in integrin expression in peripheral blood lymphocytesCrooks Christine VCross Martin LWall Clare R<p>Abstract</p> <p>Alpha integrins play an important role in cell to cell and cell to extra-cellular matrix interactions required for an effective T-lymphocyte-mediated immune response, however little is known about age related differences in expression of alpha integrins on T-cells in humans. We here measured alpha-4 (α4) integrin (CD49d) expression on T-lymphocytes via peripheral blood sampling, comparing parameters between cohorts of young and old adults. No age-related differences were found for the absolute numbers of T-cells, although the percentage of CD4+ T-cells in older adults was significantly greater and the percentage of CD8+ T-cells lower than in younger cohorts. Percentage and absolute numbers of CD3+ T-cells co-expressing CD49d were significantly lower in older adults compared to younger cohorts, and the percentage of gated CD4+ and CD8+ cells that co-labelled positively for CD49d was also reduced in this group. There were no age-related differences in circulating levels of cytokines (Type I interferons) that are known to regulate cell surface integrin expression. Reduced expression of alpha integrins on T-cells may be an early indicator of the loss of homeostatic control that occurs with ageing, contributing to diminished effector T-cell responses during senescence.</p>http://www.immunityageing.com/content/7/1/5 |
| spellingShingle | Crooks Christine V Cross Martin L Wall Clare R Age-related differences in integrin expression in peripheral blood lymphocytes Immunity & Ageing |
| title | Age-related differences in integrin expression in peripheral blood lymphocytes |
| title_full | Age-related differences in integrin expression in peripheral blood lymphocytes |
| title_fullStr | Age-related differences in integrin expression in peripheral blood lymphocytes |
| title_full_unstemmed | Age-related differences in integrin expression in peripheral blood lymphocytes |
| title_short | Age-related differences in integrin expression in peripheral blood lymphocytes |
| title_sort | age related differences in integrin expression in peripheral blood lymphocytes |
| url | http://www.immunityageing.com/content/7/1/5 |
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