Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges
Background: Degenerate eye disorders, such as glaucoma, cataracts and age-related macular degeneration (AMD), are prevalent causes of blindness and visual impairment worldwide. Other eye disorders, including limbal stem cell deficiency (LSCD), dry eye diseases (DED), and retinitis pigmentosa (RP), r...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Advances in Ophthalmology Practice and Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266737622400009X |
| _version_ | 1797235453926047744 |
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| author | Yifei Niu Junfeng Ji Ke Yao Qiuli Fu |
| author_facet | Yifei Niu Junfeng Ji Ke Yao Qiuli Fu |
| author_sort | Yifei Niu |
| collection | DOAJ |
| description | Background: Degenerate eye disorders, such as glaucoma, cataracts and age-related macular degeneration (AMD), are prevalent causes of blindness and visual impairment worldwide. Other eye disorders, including limbal stem cell deficiency (LSCD), dry eye diseases (DED), and retinitis pigmentosa (RP), result in symptoms such as ocular discomfort and impaired visual function, significantly impacting quality of life. Traditional therapies are limited, primarily focus on delaying disease progression, while emerging stem cell therapy directly targets ocular tissues, aiming to restore ocular function by reconstructing ocular tissue. Main text: The utilization of stem cells for the treatment of diverse degenerative ocular diseases is becoming increasingly significant, owing to the regenerative and malleable properties of stem cells and their functional cells. Currently, stem cell therapy for ophthalmopathy involves various cell types, such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), and retinal progenitor cells (RPCs). In the current article, we will review the current progress regarding the utilization of stem cells for the regeneration of ocular tissue covering key eye tissues from the cornea to the retina. These therapies aim to address the loss of functional cells, restore damaged ocular tissue and or in a paracrine-mediated manner. We also provide an overview of the ocular disorders that stem cell therapy is targeting, as well as the difficulties and opportunities in this field. Conclusions: Stem cells can not only promote tissue regeneration but also release exosomes to mitigate inflammation and provide neuroprotection, making stem cell therapy emerge as a promising approach for treating a wide range of eye disorders through multiple mechanisms. |
| first_indexed | 2024-04-24T16:48:12Z |
| format | Article |
| id | doaj.art-3a167b63c2574470a1f947683adfa233 |
| institution | Directory Open Access Journal |
| issn | 2667-3762 |
| language | English |
| last_indexed | 2024-04-24T16:48:12Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Ophthalmology Practice and Research |
| spelling | doaj.art-3a167b63c2574470a1f947683adfa2332024-03-29T05:51:20ZengElsevierAdvances in Ophthalmology Practice and Research2667-37622024-05-01425264Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challengesYifei Niu0Junfeng Ji1Ke Yao2Qiuli Fu3Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, Zhejiang Province, ChinaCenter of Stem Cell and Regenerative Medicine, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, Hangzhou, ChinaEye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, Zhejiang Province, China; Corresponding author. Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, Zhejiang Province, China; Corresponding author. Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.Background: Degenerate eye disorders, such as glaucoma, cataracts and age-related macular degeneration (AMD), are prevalent causes of blindness and visual impairment worldwide. Other eye disorders, including limbal stem cell deficiency (LSCD), dry eye diseases (DED), and retinitis pigmentosa (RP), result in symptoms such as ocular discomfort and impaired visual function, significantly impacting quality of life. Traditional therapies are limited, primarily focus on delaying disease progression, while emerging stem cell therapy directly targets ocular tissues, aiming to restore ocular function by reconstructing ocular tissue. Main text: The utilization of stem cells for the treatment of diverse degenerative ocular diseases is becoming increasingly significant, owing to the regenerative and malleable properties of stem cells and their functional cells. Currently, stem cell therapy for ophthalmopathy involves various cell types, such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), and retinal progenitor cells (RPCs). In the current article, we will review the current progress regarding the utilization of stem cells for the regeneration of ocular tissue covering key eye tissues from the cornea to the retina. These therapies aim to address the loss of functional cells, restore damaged ocular tissue and or in a paracrine-mediated manner. We also provide an overview of the ocular disorders that stem cell therapy is targeting, as well as the difficulties and opportunities in this field. Conclusions: Stem cells can not only promote tissue regeneration but also release exosomes to mitigate inflammation and provide neuroprotection, making stem cell therapy emerge as a promising approach for treating a wide range of eye disorders through multiple mechanisms.http://www.sciencedirect.com/science/article/pii/S266737622400009XStem cellOcular diseasesInduced pluripotent stem cellsMesenchymal stem cellsCataractsGlaucoma |
| spellingShingle | Yifei Niu Junfeng Ji Ke Yao Qiuli Fu Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges Advances in Ophthalmology Practice and Research Stem cell Ocular diseases Induced pluripotent stem cells Mesenchymal stem cells Cataracts Glaucoma |
| title | Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges |
| title_full | Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges |
| title_fullStr | Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges |
| title_full_unstemmed | Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges |
| title_short | Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges |
| title_sort | regenerative treatment of ophthalmic diseases with stem cells principles progress and challenges |
| topic | Stem cell Ocular diseases Induced pluripotent stem cells Mesenchymal stem cells Cataracts Glaucoma |
| url | http://www.sciencedirect.com/science/article/pii/S266737622400009X |
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