Ferritin-haemoglobin ratio as a predictor of severity and fatal outcome in patients with Covid-19
Background/Aim: Although ferritin and haemoglobin were well-studied for adverse outcome prediction in COVID-19 patients, a ferritin-haemoglobin ratio (FHR) was studied poorly. The study aimed to evaluate the prognostic ability of FHR at hospital admission in hypertensive and non-hypertensive patient...
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| Format: | Article |
| Language: | English |
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2023-01-01
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| Series: | Scripta Medica |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2023/2490-33292303237S.pdf |
| _version_ | 1797664596798996480 |
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| author | Skakun Oleksiy Seredyuk Nestor Fedorov Sergiy Verbovska Olha |
| author_facet | Skakun Oleksiy Seredyuk Nestor Fedorov Sergiy Verbovska Olha |
| author_sort | Skakun Oleksiy |
| collection | DOAJ |
| description | Background/Aim: Although ferritin and haemoglobin were well-studied for adverse outcome prediction in COVID-19 patients, a ferritin-haemoglobin ratio (FHR) was studied poorly. The study aimed to evaluate the prognostic ability of FHR at hospital admission in hypertensive and non-hypertensive patients with COVID-19. Methods: The study included 135 patients hospitalised for COVID-19-associated pneumonia. The 78.5 % of patients were hypertensive. Results: FHR at admission was higher in patients with critical condition (39.8 [17.1-83.0]) than in patients with moderate (22.0 [12.1-32.1], p = 0.01) and severe condition (34.6 [15.1-64.5], p = 0.01). FHR was higher in patients who required supplemental oxygen (40.4 [29.4-47.8]) than in patients without the need for supplemental oxygen (22.0 [18.0-25.5]) (p = 0.001). FHR at admission was higher in non-survivors (40.1 [24.6-95.9]) than in survivors (24.5 [21.6-28.4]) (p = 0.047). FHR showed weak discriminative ability for the prediction of severe/critical conditions in hypertensive patients (AUC = 0.636, p = 0.015) and all (hypertensive and non-hypertensive patients) patients (AUC = 0.658, p = 0.001), whereas FHR had an acceptable discriminative ability in non-hypertensive patients (AUC = 0.764, p = 0.015). There was an acceptable discriminative ability of FHR for in-hospital mortality prediction in hypertensive patients (AUC = 0.717, p = 0.029). Patients with FHR > 33.98 (Youden index, 0.39) had higher odds of severe/critical clinical condition (OR: 4.57; 95 % CI: 1.87-11.18; p = 0.001). FHR of > 37.64 (Youden index, 0.55) was associated with higher in-hospital mortality among hypertensive patients (OR: 12.06; 95 % CI: 2.44-59.71; p = 0.002). There was no difference in AUC for the discriminative ability of FHR regarding severe/ critical condition (p = 0.296) and mortality (p = 0.663) in hypertensive and non-hypertensive patients. Conclusion: FHR at admission of > 33.98 is a predictor of severe/critical COVID-19 in both hypertensive and non-hypertensive patients. FHR of > 37.64 is a predictor of in-hospital mortality in hypertensive patients. There was no significant difference in the discriminative ability of FHR between hypertensive and non-hypertensive patients. |
| first_indexed | 2024-03-11T19:31:37Z |
| format | Article |
| id | doaj.art-3a180251c2424e928022c9cf4343e128 |
| institution | Directory Open Access Journal |
| issn | 2490-3329 2303-7954 |
| language | English |
| last_indexed | 2024-03-11T19:31:37Z |
| publishDate | 2023-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj.art-3a180251c2424e928022c9cf4343e1282023-10-06T13:16:44ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542023-01-0154323724410.5937/scriptamed54-451572490-33292303237SFerritin-haemoglobin ratio as a predictor of severity and fatal outcome in patients with Covid-19Skakun Oleksiy0Seredyuk Nestor1Fedorov Sergiy2Verbovska Olha3Ivano-Frankivsk National Medical University, Department of Internal Medicine #2 and Nursing, Ivano-Frankivsk, UkraineIvano-Frankivsk National Medical University, Department of Internal Medicine #2 and Nursing, Ivano-Frankivsk, UkraineIvano-Frankivsk National Medical University, Department of Therapy, Family and Emergency Medicine of Postgraduate Education, Ivano-Frankivsk, UkraineIvano-Frankivsk Central City Clinical Hospital, Ivano-Frankivsk, UkraineBackground/Aim: Although ferritin and haemoglobin were well-studied for adverse outcome prediction in COVID-19 patients, a ferritin-haemoglobin ratio (FHR) was studied poorly. The study aimed to evaluate the prognostic ability of FHR at hospital admission in hypertensive and non-hypertensive patients with COVID-19. Methods: The study included 135 patients hospitalised for COVID-19-associated pneumonia. The 78.5 % of patients were hypertensive. Results: FHR at admission was higher in patients with critical condition (39.8 [17.1-83.0]) than in patients with moderate (22.0 [12.1-32.1], p = 0.01) and severe condition (34.6 [15.1-64.5], p = 0.01). FHR was higher in patients who required supplemental oxygen (40.4 [29.4-47.8]) than in patients without the need for supplemental oxygen (22.0 [18.0-25.5]) (p = 0.001). FHR at admission was higher in non-survivors (40.1 [24.6-95.9]) than in survivors (24.5 [21.6-28.4]) (p = 0.047). FHR showed weak discriminative ability for the prediction of severe/critical conditions in hypertensive patients (AUC = 0.636, p = 0.015) and all (hypertensive and non-hypertensive patients) patients (AUC = 0.658, p = 0.001), whereas FHR had an acceptable discriminative ability in non-hypertensive patients (AUC = 0.764, p = 0.015). There was an acceptable discriminative ability of FHR for in-hospital mortality prediction in hypertensive patients (AUC = 0.717, p = 0.029). Patients with FHR > 33.98 (Youden index, 0.39) had higher odds of severe/critical clinical condition (OR: 4.57; 95 % CI: 1.87-11.18; p = 0.001). FHR of > 37.64 (Youden index, 0.55) was associated with higher in-hospital mortality among hypertensive patients (OR: 12.06; 95 % CI: 2.44-59.71; p = 0.002). There was no difference in AUC for the discriminative ability of FHR regarding severe/ critical condition (p = 0.296) and mortality (p = 0.663) in hypertensive and non-hypertensive patients. Conclusion: FHR at admission of > 33.98 is a predictor of severe/critical COVID-19 in both hypertensive and non-hypertensive patients. FHR of > 37.64 is a predictor of in-hospital mortality in hypertensive patients. There was no significant difference in the discriminative ability of FHR between hypertensive and non-hypertensive patients.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2023/2490-33292303237S.pdfcovid-19hypertensionferritin-haemoglobin ratioseveritymortality |
| spellingShingle | Skakun Oleksiy Seredyuk Nestor Fedorov Sergiy Verbovska Olha Ferritin-haemoglobin ratio as a predictor of severity and fatal outcome in patients with Covid-19 Scripta Medica covid-19 hypertension ferritin-haemoglobin ratio severity mortality |
| title | Ferritin-haemoglobin ratio as a predictor of severity and fatal outcome in patients with Covid-19 |
| title_full | Ferritin-haemoglobin ratio as a predictor of severity and fatal outcome in patients with Covid-19 |
| title_fullStr | Ferritin-haemoglobin ratio as a predictor of severity and fatal outcome in patients with Covid-19 |
| title_full_unstemmed | Ferritin-haemoglobin ratio as a predictor of severity and fatal outcome in patients with Covid-19 |
| title_short | Ferritin-haemoglobin ratio as a predictor of severity and fatal outcome in patients with Covid-19 |
| title_sort | ferritin haemoglobin ratio as a predictor of severity and fatal outcome in patients with covid 19 |
| topic | covid-19 hypertension ferritin-haemoglobin ratio severity mortality |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2023/2490-33292303237S.pdf |
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