DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos
The Death-domain associated protein 6 (DAXX) is an evolutionarily conserved and ubiquitously expressed multifunctional protein that is implicated in many cellular processes, including transcription, cellular proliferation, cell cycle regulation, Fas-induced apoptosis, and many other events. In the n...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/3/1313 |
| _version_ | 1797406155557830656 |
|---|---|
| author | Irina Bogolyubova Dmitry Bogolyubov |
| author_facet | Irina Bogolyubova Dmitry Bogolyubov |
| author_sort | Irina Bogolyubova |
| collection | DOAJ |
| description | The Death-domain associated protein 6 (DAXX) is an evolutionarily conserved and ubiquitously expressed multifunctional protein that is implicated in many cellular processes, including transcription, cellular proliferation, cell cycle regulation, Fas-induced apoptosis, and many other events. In the nucleus, DAXX interacts with transcription factors, epigenetic modifiers, and chromatin-remodeling proteins such as the transcription regulator ATRX—the α-thalassemia/mental retardation syndrome X-linked ATP-dependent helicase II. Accordingly, DAXX is considered one of the main players involved in chromatin silencing and one of the most important factors that maintain integrity of the genome. In this brief review, we summarize available data regarding the general and specific functions of DAXX in mammalian early development, with special emphasis on the function of DAXX as a chaperone of the histone variant H3.3. Since H3.3 plays a key role in the developmental processes, especially in the pronounced rearrangements of heterochromatin compartment during oogenesis and embryogenesis, DAXX can be considered as an important factor supporting proper development. Specifically, loss of DAXX affects the recruitment of ATRX, transcription of tandem repeats and telomere functions, which results in a decrease in the viability of early embryos. |
| first_indexed | 2024-03-09T03:22:16Z |
| format | Article |
| id | doaj.art-3a187cb1f650419c8726573836865460 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:22:16Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3a187cb1f650419c87265738368654602023-12-03T15:07:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-01223131310.3390/ijms22031313DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early EmbryosIrina Bogolyubova0Dmitry Bogolyubov1Laboratory of Cell Morphology, Institute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, RussiaLaboratory of Cell Morphology, Institute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, RussiaThe Death-domain associated protein 6 (DAXX) is an evolutionarily conserved and ubiquitously expressed multifunctional protein that is implicated in many cellular processes, including transcription, cellular proliferation, cell cycle regulation, Fas-induced apoptosis, and many other events. In the nucleus, DAXX interacts with transcription factors, epigenetic modifiers, and chromatin-remodeling proteins such as the transcription regulator ATRX—the α-thalassemia/mental retardation syndrome X-linked ATP-dependent helicase II. Accordingly, DAXX is considered one of the main players involved in chromatin silencing and one of the most important factors that maintain integrity of the genome. In this brief review, we summarize available data regarding the general and specific functions of DAXX in mammalian early development, with special emphasis on the function of DAXX as a chaperone of the histone variant H3.3. Since H3.3 plays a key role in the developmental processes, especially in the pronounced rearrangements of heterochromatin compartment during oogenesis and embryogenesis, DAXX can be considered as an important factor supporting proper development. Specifically, loss of DAXX affects the recruitment of ATRX, transcription of tandem repeats and telomere functions, which results in a decrease in the viability of early embryos.https://www.mdpi.com/1422-0067/22/3/1313mammalian early developmentchromatin remodelingheterochromatinDAXXH3.3 chaperonesATRX |
| spellingShingle | Irina Bogolyubova Dmitry Bogolyubov DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos International Journal of Molecular Sciences mammalian early development chromatin remodeling heterochromatin DAXX H3.3 chaperones ATRX |
| title | DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos |
| title_full | DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos |
| title_fullStr | DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos |
| title_full_unstemmed | DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos |
| title_short | DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos |
| title_sort | daxx is a crucial factor for proper development of mammalian oocytes and early embryos |
| topic | mammalian early development chromatin remodeling heterochromatin DAXX H3.3 chaperones ATRX |
| url | https://www.mdpi.com/1422-0067/22/3/1313 |
| work_keys_str_mv | AT irinabogolyubova daxxisacrucialfactorforproperdevelopmentofmammalianoocytesandearlyembryos AT dmitrybogolyubov daxxisacrucialfactorforproperdevelopmentofmammalianoocytesandearlyembryos |