Assessing the health risk of hyperuricemia in participants with persistent organic pollutants exposure - a systematic review and meta-analysis
Based on a systematic review and meta-analysis of articles published in PubMed, Embase, Cochrane, and Web of Science, we identified nine articles that provide evidence of the relationship between persistent organic pollutants and hyperuricemia. Our researchers assess the quality of the included stud...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323000295 |
| _version_ | 1797936439876386816 |
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| author | Yipei Yu Xuyuan Quan Huijun Wang Bing Zhang Yan Hou Chang Su |
| author_facet | Yipei Yu Xuyuan Quan Huijun Wang Bing Zhang Yan Hou Chang Su |
| author_sort | Yipei Yu |
| collection | DOAJ |
| description | Based on a systematic review and meta-analysis of articles published in PubMed, Embase, Cochrane, and Web of Science, we identified nine articles that provide evidence of the relationship between persistent organic pollutants and hyperuricemia. Our researchers assess the quality of the included studies and their risk of bias using the recommended method and tool. This study uses meta-analyses of the random effects of each exposure and outcome to estimate combined odds ratios (ORs) and 95% confidence intervals (CIs). We found that the risk of hyperuricemia was strongly associated with three perfluorinated compounds, PFNA, PFOA, and PFOS, with the OR(95%CI) of 1.26 (1.07–1.47), 1.44(1.15–1.79), and 1.23(1.01–1.50) respectively. We also found a weak association between two other perfluorinated compounds, PFDA and PFHxS. Other than that, the summary ORs (95% CIs) of incident hyperuricemia were 2.34 (1.79–3.08) for DDT, 3.25(2.40–4.39) for DDE, 2.57 (1.37–4.81) for PCBs and 3.05(2.22–4.19) in trans-nonanchlor. Therefore, DDT and its breakdown product, DDE, PCBs, and trans-nonanchlor have also been linked with an increased risk of hyperuricemia in humans. This study finds that persistent organic pollutant is a critical factor for hyperuricemia, and further studies in specific regions will be considered in the future. |
| first_indexed | 2024-04-10T18:29:41Z |
| format | Article |
| id | doaj.art-3a204b5c5d5c4df8acc1508d091f0422 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-10T18:29:41Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-3a204b5c5d5c4df8acc1508d091f04222023-02-02T04:46:56ZengElsevierEcotoxicology and Environmental Safety0147-65132023-02-01251114525Assessing the health risk of hyperuricemia in participants with persistent organic pollutants exposure - a systematic review and meta-analysisYipei Yu0Xuyuan Quan1Huijun Wang2Bing Zhang3Yan Hou4Chang Su5Peking University Health Science Center, ChinaPeking University Health Science Center, ChinaChinese Center for Disease Control and Prevention National Institute for Nutrition and Health, China; Key Laboratory of Trace Element Nutrition, National Health Commission of the People's Republic of China, ChinaChinese Center for Disease Control and Prevention National Institute for Nutrition and Health, China; Key Laboratory of Trace Element Nutrition, National Health Commission of the People's Republic of China, ChinaPeking University Health Science Center, China; Correspondence to: 55 Changping Road, Beijing, China.Chinese Center for Disease Control and Prevention National Institute for Nutrition and Health, China; Key Laboratory of Trace Element Nutrition, National Health Commission of the People's Republic of China, China; Correspondence to: 55 Changping Road, Beijing, China.Based on a systematic review and meta-analysis of articles published in PubMed, Embase, Cochrane, and Web of Science, we identified nine articles that provide evidence of the relationship between persistent organic pollutants and hyperuricemia. Our researchers assess the quality of the included studies and their risk of bias using the recommended method and tool. This study uses meta-analyses of the random effects of each exposure and outcome to estimate combined odds ratios (ORs) and 95% confidence intervals (CIs). We found that the risk of hyperuricemia was strongly associated with three perfluorinated compounds, PFNA, PFOA, and PFOS, with the OR(95%CI) of 1.26 (1.07–1.47), 1.44(1.15–1.79), and 1.23(1.01–1.50) respectively. We also found a weak association between two other perfluorinated compounds, PFDA and PFHxS. Other than that, the summary ORs (95% CIs) of incident hyperuricemia were 2.34 (1.79–3.08) for DDT, 3.25(2.40–4.39) for DDE, 2.57 (1.37–4.81) for PCBs and 3.05(2.22–4.19) in trans-nonanchlor. Therefore, DDT and its breakdown product, DDE, PCBs, and trans-nonanchlor have also been linked with an increased risk of hyperuricemia in humans. This study finds that persistent organic pollutant is a critical factor for hyperuricemia, and further studies in specific regions will be considered in the future.http://www.sciencedirect.com/science/article/pii/S0147651323000295Perfluorinated compoundPersistent organic pollutantPesticideUric acidHyperuricemiaGout |
| spellingShingle | Yipei Yu Xuyuan Quan Huijun Wang Bing Zhang Yan Hou Chang Su Assessing the health risk of hyperuricemia in participants with persistent organic pollutants exposure - a systematic review and meta-analysis Ecotoxicology and Environmental Safety Perfluorinated compound Persistent organic pollutant Pesticide Uric acid Hyperuricemia Gout |
| title | Assessing the health risk of hyperuricemia in participants with persistent organic pollutants exposure - a systematic review and meta-analysis |
| title_full | Assessing the health risk of hyperuricemia in participants with persistent organic pollutants exposure - a systematic review and meta-analysis |
| title_fullStr | Assessing the health risk of hyperuricemia in participants with persistent organic pollutants exposure - a systematic review and meta-analysis |
| title_full_unstemmed | Assessing the health risk of hyperuricemia in participants with persistent organic pollutants exposure - a systematic review and meta-analysis |
| title_short | Assessing the health risk of hyperuricemia in participants with persistent organic pollutants exposure - a systematic review and meta-analysis |
| title_sort | assessing the health risk of hyperuricemia in participants with persistent organic pollutants exposure a systematic review and meta analysis |
| topic | Perfluorinated compound Persistent organic pollutant Pesticide Uric acid Hyperuricemia Gout |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323000295 |
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