Optimization of a diagnostic algorithm for benign breast nodules
The results of examinations were studied in 76 reproductive-aged patients with benign breast nodules (BBNs). The determination of the leukocyte common antigen CD45 in the trephine biopsy specimens, as well as proteinase activity in the solid tumor homogenates and in the cyst puncture samples in the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2016-06-01
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| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/473 |
| _version_ | 1797876059784347648 |
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| author | T. E. Usmanova F. N. Il’chenko A. S. Filatov A. V. Kubyshkin |
| author_facet | T. E. Usmanova F. N. Il’chenko A. S. Filatov A. V. Kubyshkin |
| author_sort | T. E. Usmanova |
| collection | DOAJ |
| description | The results of examinations were studied in 76 reproductive-aged patients with benign breast nodules (BBNs). The determination of the leukocyte common antigen CD45 in the trephine biopsy specimens, as well as proteinase activity in the solid tumor homogenates and in the cyst puncture samples in the preoperative stage or the postpuncture period can identify groups of patients with BBNs in relation to a tissue inflammatory response. BBNs with a tissue inflammatory response showed increases in the level of nonspecific proteinases and in the expression of the leukocyte common antigen CD45, which was accompanied enhanced proliferative activity (Ki-67) and elevated levels of apoptosis proteins (p53 and Bcl-2), and estrogen and prolactin receptors. |
| first_indexed | 2024-04-10T01:56:16Z |
| format | Article |
| id | doaj.art-3a20563d8d19423bb6e16a4e4c0ff3fd |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2024-04-10T01:56:16Z |
| publishDate | 2016-06-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-3a20563d8d19423bb6e16a4e4c0ff3fd2023-03-13T08:44:35ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272016-06-01121323610.17650/1994-4098-2016-12-1-32-36480Optimization of a diagnostic algorithm for benign breast nodulesT. E. Usmanova0F. N. Il’chenko1A. S. Filatov2A. V. Kubyshkin3Медицинская академия им. С. И. Георгиевского ФГАОУ ВО «Крымский федеральный университет им. В. И. Вернадского»; Россия, 295006, Симферополь, бульвар Ленина, 5 / 7Медицинская академия им. С. И. Георгиевского ФГАОУ ВО «Крымский федеральный университет им. В. И. Вернадского»; Россия, 295006, Симферополь, бульвар Ленина, 5 / 7Медицинская академия им. С. И. Георгиевского ФГАОУ ВО «Крымский федеральный университет им. В. И. Вернадского»; Россия, 295006, Симферополь, бульвар Ленина, 5 / 7Медицинская академия им. С. И. Георгиевского ФГАОУ ВО «Крымский федеральный университет им. В. И. Вернадского»; Россия, 295006, Симферополь, бульвар Ленина, 5 / 7The results of examinations were studied in 76 reproductive-aged patients with benign breast nodules (BBNs). The determination of the leukocyte common antigen CD45 in the trephine biopsy specimens, as well as proteinase activity in the solid tumor homogenates and in the cyst puncture samples in the preoperative stage or the postpuncture period can identify groups of patients with BBNs in relation to a tissue inflammatory response. BBNs with a tissue inflammatory response showed increases in the level of nonspecific proteinases and in the expression of the leukocyte common antigen CD45, which was accompanied enhanced proliferative activity (Ki-67) and elevated levels of apoptosis proteins (p53 and Bcl-2), and estrogen and prolactin receptors.https://ojrs.abvpress.ru/ojrs/article/view/473доброкачественные узловые образования молочных желездиагностиканеспецифические протеиназыиммуногистохимиявоспаление |
| spellingShingle | T. E. Usmanova F. N. Il’chenko A. S. Filatov A. V. Kubyshkin Optimization of a diagnostic algorithm for benign breast nodules Опухоли женской репродуктивной системы доброкачественные узловые образования молочных желез диагностика неспецифические протеиназы иммуногистохимия воспаление |
| title | Optimization of a diagnostic algorithm for benign breast nodules |
| title_full | Optimization of a diagnostic algorithm for benign breast nodules |
| title_fullStr | Optimization of a diagnostic algorithm for benign breast nodules |
| title_full_unstemmed | Optimization of a diagnostic algorithm for benign breast nodules |
| title_short | Optimization of a diagnostic algorithm for benign breast nodules |
| title_sort | optimization of a diagnostic algorithm for benign breast nodules |
| topic | доброкачественные узловые образования молочных желез диагностика неспецифические протеиназы иммуногистохимия воспаление |
| url | https://ojrs.abvpress.ru/ojrs/article/view/473 |
| work_keys_str_mv | AT teusmanova optimizationofadiagnosticalgorithmforbenignbreastnodules AT fnilchenko optimizationofadiagnosticalgorithmforbenignbreastnodules AT asfilatov optimizationofadiagnosticalgorithmforbenignbreastnodules AT avkubyshkin optimizationofadiagnosticalgorithmforbenignbreastnodules |