Mass Drug Administration With Artemisinin-Piperaquine for the Elimination of Residual Foci of Malaria in São Tomé Island
Background: Mass drug administration with artemisinin-piperaquine (AP-MDA) is being considered for elimination of residual foci of malaria in Democratic Republic of São Tomé and Principe.Methods: Three monthly rounds of AP-MDA were implemented from July to October 2019. Four zones were selected. A a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.617195/full |
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| author | Mingqiang Li Fei Tuo Ruixiang Tan Hongying Zhang Shaoqin Zheng Qi Wang Qin Xu Xinbing Yu Fangli Lu Zhibing Wu Jun Huang Herodes Sacramento Rampao Carlos Alberto Bandeira D'almeida Hong Yan Jianping Song Wenfeng Guo Changsheng Deng |
| author_facet | Mingqiang Li Fei Tuo Ruixiang Tan Hongying Zhang Shaoqin Zheng Qi Wang Qin Xu Xinbing Yu Fangli Lu Zhibing Wu Jun Huang Herodes Sacramento Rampao Carlos Alberto Bandeira D'almeida Hong Yan Jianping Song Wenfeng Guo Changsheng Deng |
| author_sort | Mingqiang Li |
| collection | DOAJ |
| description | Background: Mass drug administration with artemisinin-piperaquine (AP-MDA) is being considered for elimination of residual foci of malaria in Democratic Republic of São Tomé and Principe.Methods: Three monthly rounds of AP-MDA were implemented from July to October 2019. Four zones were selected. A and B were selected as a study site and a control site, respectively. C and D were located within 1.5 and 1.5 km away from the study site, respectively. Parasite prevalence, malaria incidence, and the proportion of the Plasmodium falciparum malaria cases were evaluated.Results: After 3 monthly rounds of AP-MDA, the parasite prevalence and the gametocyte carriage rate of P. falciparum in zone A decreased from 28.29(‰) to 0 and 4.99(‰) to 0, respectively. Compared to zone B, the relative risk for the population with Plasmodium falciparum malaria in zone A was lower (RR = 0.458, 95% CI: 0.146–1.437). Malaria incidence fell from 290.49(‰) (the same period of the previous year) to 15.27(‰) (from the 29th week in 2019 to the 14th week in 2020), a decrease of 94.74% in zone A, and from 31.74 to 5.46(‰), a decline of 82.80% in zone B. Compared to the data of the same period the previous year, the cumulative number of P. falciparum malaria cases were lower, decreasing from 165 to 10 in zone A and from 17 to 4 in zone B. The proportion of the P. falciparum malaria cases on the total malaria cases of the country decreased of 90.16% in zone A and 71.34% in zone C.Conclusion: AP-MDA greatly curbed malaria transmission by reducing malaria incidence in the study site and simultaneously creating a knock-on effect of malaria control within 1.5 km of the study site and within the limited time interval of 38 weeks. |
| first_indexed | 2024-12-19T16:54:38Z |
| format | Article |
| id | doaj.art-3a218b80047143d58814229128eba4a5 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-19T16:54:38Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-3a218b80047143d58814229128eba4a52022-12-21T20:13:27ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-07-01810.3389/fmed.2021.617195617195Mass Drug Administration With Artemisinin-Piperaquine for the Elimination of Residual Foci of Malaria in São Tomé IslandMingqiang Li0Fei Tuo1Ruixiang Tan2Hongying Zhang3Shaoqin Zheng4Qi Wang5Qin Xu6Xinbing Yu7Fangli Lu8Zhibing Wu9Jun Huang10Herodes Sacramento Rampao11Carlos Alberto Bandeira D'almeida12Hong Yan13Jianping Song14Wenfeng Guo15Changsheng Deng16Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaScience and Technology Park, Guangzhou University of Chinese Medicine, Guangzhou, ChinaScience and Technology Park, Guangzhou University of Chinese Medicine, Guangzhou, ChinaArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, ChinaThe First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaSino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, ChinaCentro Nacional de Endemias, Ministry of Health, São Tomé, São Tomé and PríncipeCentro Nacional de Endemias, Ministry of Health, São Tomé, São Tomé and PríncipeScience and Technology Park, Guangzhou University of Chinese Medicine, Guangzhou, ChinaArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaBackground: Mass drug administration with artemisinin-piperaquine (AP-MDA) is being considered for elimination of residual foci of malaria in Democratic Republic of São Tomé and Principe.Methods: Three monthly rounds of AP-MDA were implemented from July to October 2019. Four zones were selected. A and B were selected as a study site and a control site, respectively. C and D were located within 1.5 and 1.5 km away from the study site, respectively. Parasite prevalence, malaria incidence, and the proportion of the Plasmodium falciparum malaria cases were evaluated.Results: After 3 monthly rounds of AP-MDA, the parasite prevalence and the gametocyte carriage rate of P. falciparum in zone A decreased from 28.29(‰) to 0 and 4.99(‰) to 0, respectively. Compared to zone B, the relative risk for the population with Plasmodium falciparum malaria in zone A was lower (RR = 0.458, 95% CI: 0.146–1.437). Malaria incidence fell from 290.49(‰) (the same period of the previous year) to 15.27(‰) (from the 29th week in 2019 to the 14th week in 2020), a decrease of 94.74% in zone A, and from 31.74 to 5.46(‰), a decline of 82.80% in zone B. Compared to the data of the same period the previous year, the cumulative number of P. falciparum malaria cases were lower, decreasing from 165 to 10 in zone A and from 17 to 4 in zone B. The proportion of the P. falciparum malaria cases on the total malaria cases of the country decreased of 90.16% in zone A and 71.34% in zone C.Conclusion: AP-MDA greatly curbed malaria transmission by reducing malaria incidence in the study site and simultaneously creating a knock-on effect of malaria control within 1.5 km of the study site and within the limited time interval of 38 weeks.https://www.frontiersin.org/articles/10.3389/fmed.2021.617195/fullmass drug administrationartemisinin-piperaquineP. falciparumeliminationmalaria foci |
| spellingShingle | Mingqiang Li Fei Tuo Ruixiang Tan Hongying Zhang Shaoqin Zheng Qi Wang Qin Xu Xinbing Yu Fangli Lu Zhibing Wu Jun Huang Herodes Sacramento Rampao Carlos Alberto Bandeira D'almeida Hong Yan Jianping Song Wenfeng Guo Changsheng Deng Mass Drug Administration With Artemisinin-Piperaquine for the Elimination of Residual Foci of Malaria in São Tomé Island Frontiers in Medicine mass drug administration artemisinin-piperaquine P. falciparum elimination malaria foci |
| title | Mass Drug Administration With Artemisinin-Piperaquine for the Elimination of Residual Foci of Malaria in São Tomé Island |
| title_full | Mass Drug Administration With Artemisinin-Piperaquine for the Elimination of Residual Foci of Malaria in São Tomé Island |
| title_fullStr | Mass Drug Administration With Artemisinin-Piperaquine for the Elimination of Residual Foci of Malaria in São Tomé Island |
| title_full_unstemmed | Mass Drug Administration With Artemisinin-Piperaquine for the Elimination of Residual Foci of Malaria in São Tomé Island |
| title_short | Mass Drug Administration With Artemisinin-Piperaquine for the Elimination of Residual Foci of Malaria in São Tomé Island |
| title_sort | mass drug administration with artemisinin piperaquine for the elimination of residual foci of malaria in sao tome island |
| topic | mass drug administration artemisinin-piperaquine P. falciparum elimination malaria foci |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.617195/full |
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