Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation

Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation

Summary: Peroxisome proliferator-activated receptor α (PPARA) is a key mediator of lipid metabolism and inflammation. Activation of PPARA in rodents causes hepatocyte proliferation, but the underlying mechanism is poorly understood. This study focused on genes repressed by PPARA and analyzed the mec...

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Bibliographic Details
Main Authors: Daisuke Aibara, Shogo Takahashi, Tomoki Yagai, Donghwan Kim, Chad N. Brocker, Moshe Levi, Kimihiko Matsusue, Frank J. Gonzalez
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:iScience
Subjects:
Molecular biology
Molecular mechanism of gene regulation
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222004667

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