The SMYD family proteins in immunology: An update of their obvious and non-obvious relations with the immune system
Epigenetics is an emerging field, due to its relevance in the regulation of a wide range of biological processes. The Su(Var)3–9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing (SMYD) proteins, named SMYD1, SMYD2, SMYD3, SMYD4 and SMYD5, are enzymes tha...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844021014900 |
| _version_ | 1831548610350678016 |
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| author | Teresa Rubio-Tomás |
| author_facet | Teresa Rubio-Tomás |
| author_sort | Teresa Rubio-Tomás |
| collection | DOAJ |
| description | Epigenetics is an emerging field, due to its relevance in the regulation of a wide range of biological processes. The Su(Var)3–9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing (SMYD) proteins, named SMYD1, SMYD2, SMYD3, SMYD4 and SMYD5, are enzymes that catalyse methylation of histone and non-histone substrates, thereby playing a key role in gene expression regulation in many biological contexts, such as muscle development and physiology, haematopoiesis and many types of cancer. This review focuses on a relatively unexplored aspect of SMYD family members - their relation with immunology. Here, immunology is defined in the broadest sense of the word, including basic research on macrophage function or host immunity against pathogen infection, as well as clinical studies, most of which are centred on blood cancers. |
| first_indexed | 2024-12-17T02:23:19Z |
| format | Article |
| id | doaj.art-3a22a1509279414c85760575a4a49d89 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-17T02:23:19Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-3a22a1509279414c85760575a4a49d892022-12-21T22:07:12ZengElsevierHeliyon2405-84402021-06-0176e07387The SMYD family proteins in immunology: An update of their obvious and non-obvious relations with the immune systemTeresa Rubio-Tomás0Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain; School of Medicine, University of Crete, 70013, Herakleion, Crete, Greece; Biomedical Sciences Research Center Alexander Fleming, 16672, Vari, Greece; Corresponding author.Epigenetics is an emerging field, due to its relevance in the regulation of a wide range of biological processes. The Su(Var)3–9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing (SMYD) proteins, named SMYD1, SMYD2, SMYD3, SMYD4 and SMYD5, are enzymes that catalyse methylation of histone and non-histone substrates, thereby playing a key role in gene expression regulation in many biological contexts, such as muscle development and physiology, haematopoiesis and many types of cancer. This review focuses on a relatively unexplored aspect of SMYD family members - their relation with immunology. Here, immunology is defined in the broadest sense of the word, including basic research on macrophage function or host immunity against pathogen infection, as well as clinical studies, most of which are centred on blood cancers.http://www.sciencedirect.com/science/article/pii/S2405844021014900SMYDMethyltransferasesEpigeneticsImmunologyCancerMuscle |
| spellingShingle | Teresa Rubio-Tomás The SMYD family proteins in immunology: An update of their obvious and non-obvious relations with the immune system Heliyon SMYD Methyltransferases Epigenetics Immunology Cancer Muscle |
| title | The SMYD family proteins in immunology: An update of their obvious and non-obvious relations with the immune system |
| title_full | The SMYD family proteins in immunology: An update of their obvious and non-obvious relations with the immune system |
| title_fullStr | The SMYD family proteins in immunology: An update of their obvious and non-obvious relations with the immune system |
| title_full_unstemmed | The SMYD family proteins in immunology: An update of their obvious and non-obvious relations with the immune system |
| title_short | The SMYD family proteins in immunology: An update of their obvious and non-obvious relations with the immune system |
| title_sort | smyd family proteins in immunology an update of their obvious and non obvious relations with the immune system |
| topic | SMYD Methyltransferases Epigenetics Immunology Cancer Muscle |
| url | http://www.sciencedirect.com/science/article/pii/S2405844021014900 |
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