Tocotrienol in the Treatment of Topical Wounds: Recent Updates
Healing wounds is an important attempt to keep the internal higher organs safe. Complications in topical wound healing may lead to the formation of scars, which can affect the patient’s quality of life. Although several approaches are ongoing in parallel in the exploration of natural compounds via a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/11/2479 |
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| author | Anroop B. Nair Bapi Gorain Manisha Pandey Shery Jacob Pottathil Shinu Bandar Aldhubiab Rashed M. Almuqbil Heba S. Elsewedy Mohamed A. Morsy |
| author_facet | Anroop B. Nair Bapi Gorain Manisha Pandey Shery Jacob Pottathil Shinu Bandar Aldhubiab Rashed M. Almuqbil Heba S. Elsewedy Mohamed A. Morsy |
| author_sort | Anroop B. Nair |
| collection | DOAJ |
| description | Healing wounds is an important attempt to keep the internal higher organs safe. Complications in topical wound healing may lead to the formation of scars, which can affect the patient’s quality of life. Although several approaches are ongoing in parallel in the exploration of natural compounds via advanced delivery, in this article, an attempt has been made to highlight tocotrienol. Tocotrienol is a natural form of vitamin E and has shown its potential in certain pharmacological activities better than tocopherol. Its antioxidant, anti-inflammatory, cell signal-mediating effects, angiogenic properties, management of scar, and promotion of wound environment with essential factors have shown potential in the management of topical wound healing. Therefore, this review has aimed to focus on recent advances in topical wound healing through the application of tocotrienols. Challenges in delivering tocotrienols to the topical wound due to its large molecular weight and higher logP have also been explored using nanotechnological-based carriers, which has made tocotrienol a potential tool to facilitate the closure of wounds. Exploration of tocotrienol has also been made in human volunteers for biopsy wounds; however, the results are yet to be reported. Overall, based on the current findings in the literature, it could be inferred that tocotrienol would be a viable alternative to the existing wound dressing components for the management of topical wounds. |
| first_indexed | 2024-03-09T18:04:36Z |
| format | Article |
| id | doaj.art-3a234e18df1a487b8b8622d27bd2bb08 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T18:04:36Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3a234e18df1a487b8b8622d27bd2bb082023-11-24T09:36:30ZengMDPI AGPharmaceutics1999-49232022-11-011411247910.3390/pharmaceutics14112479Tocotrienol in the Treatment of Topical Wounds: Recent UpdatesAnroop B. Nair0Bapi Gorain1Manisha Pandey2Shery Jacob3Pottathil Shinu4Bandar Aldhubiab5Rashed M. Almuqbil6Heba S. Elsewedy7Mohamed A. Morsy8Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, IndiaDepartment of Pharmaceutical Sciences, Central University of Haryana, SSH 17, Jant, Mahendergarh 123031, IndiaDepartment of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman 4184, United Arab EmiratesDepartment of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaHealing wounds is an important attempt to keep the internal higher organs safe. Complications in topical wound healing may lead to the formation of scars, which can affect the patient’s quality of life. Although several approaches are ongoing in parallel in the exploration of natural compounds via advanced delivery, in this article, an attempt has been made to highlight tocotrienol. Tocotrienol is a natural form of vitamin E and has shown its potential in certain pharmacological activities better than tocopherol. Its antioxidant, anti-inflammatory, cell signal-mediating effects, angiogenic properties, management of scar, and promotion of wound environment with essential factors have shown potential in the management of topical wound healing. Therefore, this review has aimed to focus on recent advances in topical wound healing through the application of tocotrienols. Challenges in delivering tocotrienols to the topical wound due to its large molecular weight and higher logP have also been explored using nanotechnological-based carriers, which has made tocotrienol a potential tool to facilitate the closure of wounds. Exploration of tocotrienol has also been made in human volunteers for biopsy wounds; however, the results are yet to be reported. Overall, based on the current findings in the literature, it could be inferred that tocotrienol would be a viable alternative to the existing wound dressing components for the management of topical wounds.https://www.mdpi.com/1999-4923/14/11/2479tocotrienolstopical woundnanotechnologychallengesgrowth factorwound closure |
| spellingShingle | Anroop B. Nair Bapi Gorain Manisha Pandey Shery Jacob Pottathil Shinu Bandar Aldhubiab Rashed M. Almuqbil Heba S. Elsewedy Mohamed A. Morsy Tocotrienol in the Treatment of Topical Wounds: Recent Updates Pharmaceutics tocotrienols topical wound nanotechnology challenges growth factor wound closure |
| title | Tocotrienol in the Treatment of Topical Wounds: Recent Updates |
| title_full | Tocotrienol in the Treatment of Topical Wounds: Recent Updates |
| title_fullStr | Tocotrienol in the Treatment of Topical Wounds: Recent Updates |
| title_full_unstemmed | Tocotrienol in the Treatment of Topical Wounds: Recent Updates |
| title_short | Tocotrienol in the Treatment of Topical Wounds: Recent Updates |
| title_sort | tocotrienol in the treatment of topical wounds recent updates |
| topic | tocotrienols topical wound nanotechnology challenges growth factor wound closure |
| url | https://www.mdpi.com/1999-4923/14/11/2479 |
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