Acute limb ischemia secondary to vaccine-induced inmune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV-19
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a syndrome that resembles to heparin-induced thrombocytopenia (HIT). Platelet factor 4 (PF-4) reacts to a vaccine component resulting formation of immune complex that stimulates an autoimmune reaction triggering platelet consumption causin...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
|
| Series: | Annals of Vascular Surgery - Brief Reports and Innovations |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772687822000642 |
| _version_ | 1797788378086768640 |
|---|---|
| author | Fernando García-Boyano Clara M. Castro Ávila Miguel Arguello-Tomás Álvaro Moreno Cuervo José Manuel Ligero Ramos Cristina Pascual-Izquierdo |
| author_facet | Fernando García-Boyano Clara M. Castro Ávila Miguel Arguello-Tomás Álvaro Moreno Cuervo José Manuel Ligero Ramos Cristina Pascual-Izquierdo |
| author_sort | Fernando García-Boyano |
| collection | DOAJ |
| description | Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a syndrome that resembles to heparin-induced thrombocytopenia (HIT). Platelet factor 4 (PF-4) reacts to a vaccine component resulting formation of immune complex that stimulates an autoimmune reaction triggering platelet consumption causing thrombus formation and producing thrombotic events. When suspected is important to confirm for make a correct anticoagulation management to avoid complications related to unfractioned and low weight heparins use.In this report we describe a case of acute limb ischemia secondary to ChAdOx1 nCoV-19 vaccine (Astrazeneca, Cambridge, UK) |
| first_indexed | 2024-03-13T01:34:42Z |
| format | Article |
| id | doaj.art-3a2385cfa2cd4a3c92fcafa5c49761b3 |
| institution | Directory Open Access Journal |
| issn | 2772-6878 |
| language | English |
| last_indexed | 2024-03-13T01:34:42Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Vascular Surgery - Brief Reports and Innovations |
| spelling | doaj.art-3a2385cfa2cd4a3c92fcafa5c49761b32023-07-04T05:11:50ZengElsevierAnnals of Vascular Surgery - Brief Reports and Innovations2772-68782022-09-0123100102Acute limb ischemia secondary to vaccine-induced inmune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV-19Fernando García-Boyano0Clara M. Castro Ávila1Miguel Arguello-Tomás2Álvaro Moreno Cuervo3José Manuel Ligero Ramos4Cristina Pascual-Izquierdo5Angiology and Vascular Surgery Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain; Corresponding author at: Department of Vascular Surgery of Hospital General Universitario Gregorio Marañón de Madrid. Universidad Complutense de Madrid. C/ Dr. Esquerdo 46, Madrid 28007, Spain.Angiology and Vascular Surgery Department, Hospital General Universitario Gregorio Marañon, Madrid, SpainHaematology Department, Hospital General Universitario Gregorio Marañon, Madrid, SpainAngiology and Vascular Surgery Department, Hospital General Universitario Gregorio Marañon, Madrid, SpainAngiology and Vascular Surgery Department, Hospital General Universitario Gregorio Marañon, Madrid, SpainHaematology Department, Hospital General Universitario Gregorio Marañon, Madrid, SpainVaccine-induced immune thrombotic thrombocytopenia (VITT) is a syndrome that resembles to heparin-induced thrombocytopenia (HIT). Platelet factor 4 (PF-4) reacts to a vaccine component resulting formation of immune complex that stimulates an autoimmune reaction triggering platelet consumption causing thrombus formation and producing thrombotic events. When suspected is important to confirm for make a correct anticoagulation management to avoid complications related to unfractioned and low weight heparins use.In this report we describe a case of acute limb ischemia secondary to ChAdOx1 nCoV-19 vaccine (Astrazeneca, Cambridge, UK)http://www.sciencedirect.com/science/article/pii/S2772687822000642VITTAcute limb ischemiaCovid19 |
| spellingShingle | Fernando García-Boyano Clara M. Castro Ávila Miguel Arguello-Tomás Álvaro Moreno Cuervo José Manuel Ligero Ramos Cristina Pascual-Izquierdo Acute limb ischemia secondary to vaccine-induced inmune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV-19 Annals of Vascular Surgery - Brief Reports and Innovations VITT Acute limb ischemia Covid19 |
| title | Acute limb ischemia secondary to vaccine-induced inmune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV-19 |
| title_full | Acute limb ischemia secondary to vaccine-induced inmune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV-19 |
| title_fullStr | Acute limb ischemia secondary to vaccine-induced inmune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV-19 |
| title_full_unstemmed | Acute limb ischemia secondary to vaccine-induced inmune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV-19 |
| title_short | Acute limb ischemia secondary to vaccine-induced inmune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV-19 |
| title_sort | acute limb ischemia secondary to vaccine induced inmune thrombotic thrombocytopenia vitt after chadox1 ncov 19 |
| topic | VITT Acute limb ischemia Covid19 |
| url | http://www.sciencedirect.com/science/article/pii/S2772687822000642 |
| work_keys_str_mv | AT fernandogarciaboyano acutelimbischemiasecondarytovaccineinducedinmunethromboticthrombocytopeniavittafterchadox1ncov19 AT claramcastroavila acutelimbischemiasecondarytovaccineinducedinmunethromboticthrombocytopeniavittafterchadox1ncov19 AT miguelarguellotomas acutelimbischemiasecondarytovaccineinducedinmunethromboticthrombocytopeniavittafterchadox1ncov19 AT alvaromorenocuervo acutelimbischemiasecondarytovaccineinducedinmunethromboticthrombocytopeniavittafterchadox1ncov19 AT josemanuelligeroramos acutelimbischemiasecondarytovaccineinducedinmunethromboticthrombocytopeniavittafterchadox1ncov19 AT cristinapascualizquierdo acutelimbischemiasecondarytovaccineinducedinmunethromboticthrombocytopeniavittafterchadox1ncov19 |