(Epi)genetics of pregnancy-associated diseases
This review describes the current knowledge regarding genetics and epigenetics of pregnancy-associated diseases. We discuss the effect on genetic linkage analyses when the fetal genotype determines the maternal phenotype. Secondly, the genes identified by genome-wide linkage studies to be associated...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-09-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00180/full |
| _version_ | 1818290623174672384 |
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| author | Cees eOudejans Marie eVan Dijk |
| author_facet | Cees eOudejans Marie eVan Dijk |
| author_sort | Cees eOudejans |
| collection | DOAJ |
| description | This review describes the current knowledge regarding genetics and epigenetics of pregnancy-associated diseases. We discuss the effect on genetic linkage analyses when the fetal genotype determines the maternal phenotype. Secondly, the genes identified by genome-wide linkage studies to be associated with pre-eclampsia (ACVR2A, STOX1) and the HELLP-syndrome (LINC-HELLP) are discussed regarding their potential functions in the etiology of disease. Furthermore, susceptibility genes identified by candidate gene approaches (e.g. CORIN) are described.Next we focus on the additional challenges that come when epigenetics also play a role in disease inheritance. We discuss the maternal transmission of the chromosome 10q22 pre-eclampsia linkage region containing the STOX1 gene and provide further evidence for the role of epigenetics in pre-eclampsia based on the cdkn1c mouse model of pre-eclampsia. Finally, we provide recommendations to unravel the genetics of pregnancy-associated diseases, specifically regarding clear definitions of patient groups and sufficient patient numbers, and the potential usefulness of (epi)genetic data in early non-invasive biomarker development. |
| first_indexed | 2024-12-13T02:31:07Z |
| format | Article |
| id | doaj.art-3a28227550914e2fab3f0878bcd295ba |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-13T02:31:07Z |
| publishDate | 2013-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-3a28227550914e2fab3f0878bcd295ba2022-12-22T00:02:30ZengFrontiers Media S.A.Frontiers in Genetics1664-80212013-09-01410.3389/fgene.2013.0018060542(Epi)genetics of pregnancy-associated diseasesCees eOudejans0Marie eVan Dijk1VU University Medical CenterVU University Medical CenterThis review describes the current knowledge regarding genetics and epigenetics of pregnancy-associated diseases. We discuss the effect on genetic linkage analyses when the fetal genotype determines the maternal phenotype. Secondly, the genes identified by genome-wide linkage studies to be associated with pre-eclampsia (ACVR2A, STOX1) and the HELLP-syndrome (LINC-HELLP) are discussed regarding their potential functions in the etiology of disease. Furthermore, susceptibility genes identified by candidate gene approaches (e.g. CORIN) are described.Next we focus on the additional challenges that come when epigenetics also play a role in disease inheritance. We discuss the maternal transmission of the chromosome 10q22 pre-eclampsia linkage region containing the STOX1 gene and provide further evidence for the role of epigenetics in pre-eclampsia based on the cdkn1c mouse model of pre-eclampsia. Finally, we provide recommendations to unravel the genetics of pregnancy-associated diseases, specifically regarding clear definitions of patient groups and sufficient patient numbers, and the potential usefulness of (epi)genetic data in early non-invasive biomarker development.http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00180/fullHELLP SyndromePlacentaPre-EclampsiaTrophoblastsepigeneticsimprinting |
| spellingShingle | Cees eOudejans Marie eVan Dijk (Epi)genetics of pregnancy-associated diseases Frontiers in Genetics HELLP Syndrome Placenta Pre-Eclampsia Trophoblasts epigenetics imprinting |
| title | (Epi)genetics of pregnancy-associated diseases |
| title_full | (Epi)genetics of pregnancy-associated diseases |
| title_fullStr | (Epi)genetics of pregnancy-associated diseases |
| title_full_unstemmed | (Epi)genetics of pregnancy-associated diseases |
| title_short | (Epi)genetics of pregnancy-associated diseases |
| title_sort | epi genetics of pregnancy associated diseases |
| topic | HELLP Syndrome Placenta Pre-Eclampsia Trophoblasts epigenetics imprinting |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00180/full |
| work_keys_str_mv | AT ceeseoudejans epigeneticsofpregnancyassociateddiseases AT marieevandijk epigeneticsofpregnancyassociateddiseases |