Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation

Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation

In endoplasmic reticulum-associated protein degradation (ERAD), membrane proteins are ubiquitinated, extracted from the membrane, and degraded by the proteasome. The cytosolic ATPase Cdc48 drives extraction by pulling on polyubiquitinated substrates. How hydrophobic transmembrane (TM) segments are m...

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Bibliographic Details
Main Authors: Claudia C Schmidt, Vedran Vasic, Alexander Stein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
ERAD
protein quality control
protein translocation
ubiquitin proteasome system
membrane proteins
in vitro reconstitution
Online Access:https://elifesciences.org/articles/56945

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