HDL-C Role in Acquired Aortic Valve Stenosis Patients and Its Relationship with Oxidative Stress
<i>Background and objectives</i>: Mechanical stress is currently considered as the main factor promoting calcific aortic valve stenosis (AS) onset. It causes endothelial damage and dysfunction. The chronic inflammatory process causes oxidative stress. Oxidative stress-induced high-densit...
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MDPI AG
2019-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/8/416 |
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| author | Juris Hofmanis Dace Hofmane Simons Svirskis Vitolds Mackevics Peteris Tretjakovs Aivars Lejnieks Salvatore Santo Signorelli |
| author_facet | Juris Hofmanis Dace Hofmane Simons Svirskis Vitolds Mackevics Peteris Tretjakovs Aivars Lejnieks Salvatore Santo Signorelli |
| author_sort | Juris Hofmanis |
| collection | DOAJ |
| description | <i>Background and objectives</i>: Mechanical stress is currently considered as the main factor promoting calcific aortic valve stenosis (AS) onset. It causes endothelial damage and dysfunction. The chronic inflammatory process causes oxidative stress. Oxidative stress-induced high-density lipoprotein cholesterol (HDL-C) dysfunction is an important component of the development of AS. The aim of the study was to evaluate the role of HDL-C in AS patients in three severity grades and in relation to the biomarkers of oxidative stress, thioredoxin reductase 1 (TrxR1) and myeloperoxidase (MPO). <i>Materials and Methods</i>: 18 patients with mild, 19 with moderate. and 15 with severe AS were included in the study, and 50 individuals were enrolled in the control group. Stenosis severity was determined by echocardiography. The TrxR1 and MPO were analyzed by ELISA, and HDL-C by commercially available tests. Data were analyzed using GraphPad Prism 8. <i>Results</i>: HDL-C in AS patients vs. control substantially decreases and this decline was observed in all three AS severity groups: mild (<i>p</i> = 0.018), moderate (<i>p</i> = 0.0002), and severe (<i>p</i> = 0.004). In both the control and the stenosis group, the HDL-C was higher in women than in men. In comparison to control, the HDL-C level was lower in the AS group, and more pronounced in women (<i>p</i> = 0.0001) than in men (<i>p</i> = 0.049). A higher TrxR1 level was observed in patients with mild (<i>p</i> = 0.0001) and severe AS (<i>p</i> = 0.047). However, a clear correlation between TrxR1 and HDL-C was not obtained. Analysis of MPO showed differences in all severity grades vs. control (<i>p</i> = 0.024 mild stenosis; <i>p</i> = 0.002 moderate stenosis; <i>p</i> = 0.0015 severe stenosis). A negative correlation (<i>p</i> = 0.047; <i>rp</i> = −0.28) was found between MPO and HDL-C, which confirms the adverse effects of MPO resulting in HDL-C dysfunction. <i>Conclusions</i>: In this study, we justified HDL-C level association with AS development process. The results unequivocally substantiated the association between HDL-C and AS in all severity grades in women, but only in moderate AS for men, which we explained by the small number of men in the groups. The obtained correlation between the HDL-C and MPO levels, as well as the concurrent decrease in the HDL-C level and increase in the TrxR1 level, indicate in general an HDL-C association with oxidative stress in AS patients. |
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| last_indexed | 2024-03-12T09:21:06Z |
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| spelling | doaj.art-3a287e0c77664193b0d38e459e4e79e92023-09-02T14:28:13ZengMDPI AGMedicina1010-660X2019-07-0155841610.3390/medicina55080416medicina55080416HDL-C Role in Acquired Aortic Valve Stenosis Patients and Its Relationship with Oxidative StressJuris Hofmanis0Dace Hofmane1Simons Svirskis2Vitolds Mackevics3Peteris Tretjakovs4Aivars Lejnieks5Salvatore Santo Signorelli6Faculty of Medicine, Department of Internal Diseases, Riga Stradins University and Riga East University Hospital, LV-1007 Riga, LatviaZemgale Health Center, LV-3001 Jelgava, LatviaInstitute of Microbiology and Virology, Riga Stradins University, LV-1007 Riga, LatviaFaculty of Medicine, Department of Internal Diseases, Riga Stradins University and Riga East University Hospital, LV-1007 Riga, LatviaFaculty of Medicine, Department of Human Physiology and Biochemistry, Riga Stradins University, LV-1007 Riga, LatviaFaculty of Medicine, Department of Internal Diseases, Riga Stradins University and Riga East University Hospital, LV-1007 Riga, LatviaDepartment of Clinical and Experimental Medicine, University of Catania and c/o University Hospital “G.Rodolico”, 95123 Catania, Italy<i>Background and objectives</i>: Mechanical stress is currently considered as the main factor promoting calcific aortic valve stenosis (AS) onset. It causes endothelial damage and dysfunction. The chronic inflammatory process causes oxidative stress. Oxidative stress-induced high-density lipoprotein cholesterol (HDL-C) dysfunction is an important component of the development of AS. The aim of the study was to evaluate the role of HDL-C in AS patients in three severity grades and in relation to the biomarkers of oxidative stress, thioredoxin reductase 1 (TrxR1) and myeloperoxidase (MPO). <i>Materials and Methods</i>: 18 patients with mild, 19 with moderate. and 15 with severe AS were included in the study, and 50 individuals were enrolled in the control group. Stenosis severity was determined by echocardiography. The TrxR1 and MPO were analyzed by ELISA, and HDL-C by commercially available tests. Data were analyzed using GraphPad Prism 8. <i>Results</i>: HDL-C in AS patients vs. control substantially decreases and this decline was observed in all three AS severity groups: mild (<i>p</i> = 0.018), moderate (<i>p</i> = 0.0002), and severe (<i>p</i> = 0.004). In both the control and the stenosis group, the HDL-C was higher in women than in men. In comparison to control, the HDL-C level was lower in the AS group, and more pronounced in women (<i>p</i> = 0.0001) than in men (<i>p</i> = 0.049). A higher TrxR1 level was observed in patients with mild (<i>p</i> = 0.0001) and severe AS (<i>p</i> = 0.047). However, a clear correlation between TrxR1 and HDL-C was not obtained. Analysis of MPO showed differences in all severity grades vs. control (<i>p</i> = 0.024 mild stenosis; <i>p</i> = 0.002 moderate stenosis; <i>p</i> = 0.0015 severe stenosis). A negative correlation (<i>p</i> = 0.047; <i>rp</i> = −0.28) was found between MPO and HDL-C, which confirms the adverse effects of MPO resulting in HDL-C dysfunction. <i>Conclusions</i>: In this study, we justified HDL-C level association with AS development process. The results unequivocally substantiated the association between HDL-C and AS in all severity grades in women, but only in moderate AS for men, which we explained by the small number of men in the groups. The obtained correlation between the HDL-C and MPO levels, as well as the concurrent decrease in the HDL-C level and increase in the TrxR1 level, indicate in general an HDL-C association with oxidative stress in AS patients.https://www.mdpi.com/1010-660X/55/8/416aortic valve stenosisASmyeloperoxidaseMPOhigh-density lipoprotein cholesterolHDL-Cthioredoxin reductase 1TrxR1oxidative stress |
| spellingShingle | Juris Hofmanis Dace Hofmane Simons Svirskis Vitolds Mackevics Peteris Tretjakovs Aivars Lejnieks Salvatore Santo Signorelli HDL-C Role in Acquired Aortic Valve Stenosis Patients and Its Relationship with Oxidative Stress Medicina aortic valve stenosis AS myeloperoxidase MPO high-density lipoprotein cholesterol HDL-C thioredoxin reductase 1 TrxR1 oxidative stress |
| title | HDL-C Role in Acquired Aortic Valve Stenosis Patients and Its Relationship with Oxidative Stress |
| title_full | HDL-C Role in Acquired Aortic Valve Stenosis Patients and Its Relationship with Oxidative Stress |
| title_fullStr | HDL-C Role in Acquired Aortic Valve Stenosis Patients and Its Relationship with Oxidative Stress |
| title_full_unstemmed | HDL-C Role in Acquired Aortic Valve Stenosis Patients and Its Relationship with Oxidative Stress |
| title_short | HDL-C Role in Acquired Aortic Valve Stenosis Patients and Its Relationship with Oxidative Stress |
| title_sort | hdl c role in acquired aortic valve stenosis patients and its relationship with oxidative stress |
| topic | aortic valve stenosis AS myeloperoxidase MPO high-density lipoprotein cholesterol HDL-C thioredoxin reductase 1 TrxR1 oxidative stress |
| url | https://www.mdpi.com/1010-660X/55/8/416 |
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