The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese population
Abstract Objectives The aim of this study was to assess and compare the diagnostic utility of a new diagnostic criteria for amyotrophic lateral sclerosis (ALS), abbreviated as the ‘Gold Coast Criteria’, with the revised El Escorial (rEEC) and Awaji criteria. Methods Clinical and electrophysiological...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-08-01
|
| Series: | Translational Neurodegeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40035-021-00253-2 |
| _version_ | 1818595909222531072 |
|---|---|
| author | Dongchao Shen Xunzhe Yang Yanying Wang Di He Xiaohan Sun Zhengyi Cai Jinyue Li Mingsheng Liu Liying Cui |
| author_facet | Dongchao Shen Xunzhe Yang Yanying Wang Di He Xiaohan Sun Zhengyi Cai Jinyue Li Mingsheng Liu Liying Cui |
| author_sort | Dongchao Shen |
| collection | DOAJ |
| description | Abstract Objectives The aim of this study was to assess and compare the diagnostic utility of a new diagnostic criteria for amyotrophic lateral sclerosis (ALS), abbreviated as the ‘Gold Coast Criteria’, with the revised El Escorial (rEEC) and Awaji criteria. Methods Clinical and electrophysiological data of 1185 patients from January 2014 to December 2019 in the Peking Union Medical College Hospital ALS database were reviewed. The sensitivity of the Gold Coast criteria was compared to that of the possible rEEC and Awaji criteria (defined by the proportion of patients categorized as definite, probable, or possible ALS). Results A final diagnosis of ALS was recorded in 1162 patients. The sensitivity of the Gold Coast criteria (96.6%, 95% confidence interval [CI] = 95.3%–97.5%) was greater than that of the rEEC (85.1%, 95%CI = 82.9%–87.1%) and Awaji (85.3%, 95%CI = 83.2%–87.3%). In addition, the sensitivity of the novel criteria maintained robust across subgroups, and the advantage was more prominent in limb-onset ALS patients and those who completed electromyographic tests. In those who did not achieve any of the rEEC diagnostic categories, the sensitivity of Gold Coast criteria was 84.4%. Conclusions The current study demonstrated that the Gold Coast criteria exhibited greater diagnostic sensitivity than the rEEC and Awaji criteria in a Chinese ALS population. The application of the Gold Coast criteria should be considered in clinical practice and future therapeutic trials. |
| first_indexed | 2024-12-16T11:23:30Z |
| format | Article |
| id | doaj.art-3a28eb09a8444cf6b1603c18ca205fe0 |
| institution | Directory Open Access Journal |
| issn | 2047-9158 |
| language | English |
| last_indexed | 2024-12-16T11:23:30Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Translational Neurodegeneration |
| spelling | doaj.art-3a28eb09a8444cf6b1603c18ca205fe02022-12-21T22:33:25ZengBMCTranslational Neurodegeneration2047-91582021-08-011011810.1186/s40035-021-00253-2The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese populationDongchao Shen0Xunzhe Yang1Yanying Wang2Di He3Xiaohan Sun4Zhengyi Cai5Jinyue Li6Mingsheng Liu7Liying Cui8Department of Neurology, Peking Union Medical College HospitalDepartment of Neurology, Peking Union Medical College HospitalDepartment of Neurology, Peking Union Medical College HospitalDepartment of Neurology, Peking Union Medical College HospitalDepartment of Neurology, Peking Union Medical College HospitalDepartment of Neurology, Peking Union Medical College HospitalDepartment of Neurology, Peking Union Medical College HospitalDepartment of Neurology, Peking Union Medical College HospitalDepartment of Neurology, Peking Union Medical College HospitalAbstract Objectives The aim of this study was to assess and compare the diagnostic utility of a new diagnostic criteria for amyotrophic lateral sclerosis (ALS), abbreviated as the ‘Gold Coast Criteria’, with the revised El Escorial (rEEC) and Awaji criteria. Methods Clinical and electrophysiological data of 1185 patients from January 2014 to December 2019 in the Peking Union Medical College Hospital ALS database were reviewed. The sensitivity of the Gold Coast criteria was compared to that of the possible rEEC and Awaji criteria (defined by the proportion of patients categorized as definite, probable, or possible ALS). Results A final diagnosis of ALS was recorded in 1162 patients. The sensitivity of the Gold Coast criteria (96.6%, 95% confidence interval [CI] = 95.3%–97.5%) was greater than that of the rEEC (85.1%, 95%CI = 82.9%–87.1%) and Awaji (85.3%, 95%CI = 83.2%–87.3%). In addition, the sensitivity of the novel criteria maintained robust across subgroups, and the advantage was more prominent in limb-onset ALS patients and those who completed electromyographic tests. In those who did not achieve any of the rEEC diagnostic categories, the sensitivity of Gold Coast criteria was 84.4%. Conclusions The current study demonstrated that the Gold Coast criteria exhibited greater diagnostic sensitivity than the rEEC and Awaji criteria in a Chinese ALS population. The application of the Gold Coast criteria should be considered in clinical practice and future therapeutic trials.https://doi.org/10.1186/s40035-021-00253-2Amyotrophic lateral sclerosisDiagnostic criteriaGold CoastSensitivity |
| spellingShingle | Dongchao Shen Xunzhe Yang Yanying Wang Di He Xiaohan Sun Zhengyi Cai Jinyue Li Mingsheng Liu Liying Cui The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese population Translational Neurodegeneration Amyotrophic lateral sclerosis Diagnostic criteria Gold Coast Sensitivity |
| title | The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese population |
| title_full | The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese population |
| title_fullStr | The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese population |
| title_full_unstemmed | The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese population |
| title_short | The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese population |
| title_sort | the gold coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a chinese population |
| topic | Amyotrophic lateral sclerosis Diagnostic criteria Gold Coast Sensitivity |
| url | https://doi.org/10.1186/s40035-021-00253-2 |
| work_keys_str_mv | AT dongchaoshen thegoldcoastcriteriaincreasesthediagnosticsensitivityforamyotrophiclateralsclerosisinachinesepopulation AT xunzheyang thegoldcoastcriteriaincreasesthediagnosticsensitivityforamyotrophiclateralsclerosisinachinesepopulation AT yanyingwang thegoldcoastcriteriaincreasesthediagnosticsensitivityforamyotrophiclateralsclerosisinachinesepopulation AT dihe thegoldcoastcriteriaincreasesthediagnosticsensitivityforamyotrophiclateralsclerosisinachinesepopulation AT xiaohansun thegoldcoastcriteriaincreasesthediagnosticsensitivityforamyotrophiclateralsclerosisinachinesepopulation AT zhengyicai thegoldcoastcriteriaincreasesthediagnosticsensitivityforamyotrophiclateralsclerosisinachinesepopulation AT jinyueli thegoldcoastcriteriaincreasesthediagnosticsensitivityforamyotrophiclateralsclerosisinachinesepopulation AT mingshengliu thegoldcoastcriteriaincreasesthediagnosticsensitivityforamyotrophiclateralsclerosisinachinesepopulation AT liyingcui thegoldcoastcriteriaincreasesthediagnosticsensitivityforamyotrophiclateralsclerosisinachinesepopulation |