The Experience of Fertility Preservation in a Single Tertiary Center in Korea
ObjectiveOocyte (OC), embryo (EC), and ovarian tissue cryopreservation (OTC) are options for fertility preservation (FP) before going through gonadotoxic cancer treatment, or anticipated fertility decline in benign ovarian diseases, or for planned OC. The aim of this study is to report outcomes of F...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.845051/full |
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| author | Yae Ji Choi Yae Ji Choi Yeon Hee Hong Yeon Hee Hong Seongbeen Kim Seul Ki Kim Seul Ki Kim Jung Ryeol Lee Jung Ryeol Lee Chang Suk Suh Chang Suk Suh |
| author_facet | Yae Ji Choi Yae Ji Choi Yeon Hee Hong Yeon Hee Hong Seongbeen Kim Seul Ki Kim Seul Ki Kim Jung Ryeol Lee Jung Ryeol Lee Chang Suk Suh Chang Suk Suh |
| author_sort | Yae Ji Choi |
| collection | DOAJ |
| description | ObjectiveOocyte (OC), embryo (EC), and ovarian tissue cryopreservation (OTC) are options for fertility preservation (FP) before going through gonadotoxic cancer treatment, or anticipated fertility decline in benign ovarian diseases, or for planned OC. The aim of this study is to report outcomes of FP in a single tertiary hospital in Korea.MethodsThis is a retrospective study of OC, EC, and OTC cycles. All patients who visited or were referred to the infertility clinic at the Department of Obstetrics and Gynecology for the purpose of FP between 2010 and October 2021 were included.ResultsA total of 564 controlled ovarian stimulation cycles were conducted in 416 women. Three hundred fifty-seven women underwent 494 OC cycles. Most patients were diagnosed with breast cancer (22.4%), followed by endometriomas (21.9%), and then by planned OC (20.7%). Cases of OC have increased over the years, peaking at 109 cycles in 2019 compared to one in 2010. Fifty-nine women underwent 70 EC cycles, and breast cancer (50.8%) was the most common indication. Repetitive OC and EC cycles were undergone in 92 and 9 women, respectively (mean number of repetition, 1.37 and 1.19 times in OC and EC, respectively), yielding a maximum number of 33 oocytes or 23 embryos being cryopreserved per patient. The utilization rate was 3.1% (11/357) in OC and 16.9% (10/59) in EC. Twenty-six women underwent OTC, and gynecologic cancer was the most common indication (9/26, 34.6%). One woman had the cryopreserved ovarian tissue retransplanted and successfully generated embryos.ConclusionOC, EC, and OTC are possible options for preserving fertility, and these opportunities should be provided for women at risk of fertility decline or those who are eager to protect their future fertility. This is the first report on long-term FP outcomes in a single tertiary center in Korea. We expect that there will be more cases over the years and more women returning to use their gametes or embryos for pregnancy. |
| first_indexed | 2024-12-12T21:31:08Z |
| format | Article |
| id | doaj.art-3a29ea1f853443f78e358631c4973b96 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T21:31:08Z |
| publishDate | 2022-04-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-3a29ea1f853443f78e358631c4973b962022-12-22T00:11:19ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-04-011310.3389/fendo.2022.845051845051The Experience of Fertility Preservation in a Single Tertiary Center in KoreaYae Ji Choi0Yae Ji Choi1Yeon Hee Hong2Yeon Hee Hong3Seongbeen Kim4Seul Ki Kim5Seul Ki Kim6Jung Ryeol Lee7Jung Ryeol Lee8Chang Suk Suh9Chang Suk Suh10Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South KoreaDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Surgical Oncology, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah, United Arab EmiratesObjectiveOocyte (OC), embryo (EC), and ovarian tissue cryopreservation (OTC) are options for fertility preservation (FP) before going through gonadotoxic cancer treatment, or anticipated fertility decline in benign ovarian diseases, or for planned OC. The aim of this study is to report outcomes of FP in a single tertiary hospital in Korea.MethodsThis is a retrospective study of OC, EC, and OTC cycles. All patients who visited or were referred to the infertility clinic at the Department of Obstetrics and Gynecology for the purpose of FP between 2010 and October 2021 were included.ResultsA total of 564 controlled ovarian stimulation cycles were conducted in 416 women. Three hundred fifty-seven women underwent 494 OC cycles. Most patients were diagnosed with breast cancer (22.4%), followed by endometriomas (21.9%), and then by planned OC (20.7%). Cases of OC have increased over the years, peaking at 109 cycles in 2019 compared to one in 2010. Fifty-nine women underwent 70 EC cycles, and breast cancer (50.8%) was the most common indication. Repetitive OC and EC cycles were undergone in 92 and 9 women, respectively (mean number of repetition, 1.37 and 1.19 times in OC and EC, respectively), yielding a maximum number of 33 oocytes or 23 embryos being cryopreserved per patient. The utilization rate was 3.1% (11/357) in OC and 16.9% (10/59) in EC. Twenty-six women underwent OTC, and gynecologic cancer was the most common indication (9/26, 34.6%). One woman had the cryopreserved ovarian tissue retransplanted and successfully generated embryos.ConclusionOC, EC, and OTC are possible options for preserving fertility, and these opportunities should be provided for women at risk of fertility decline or those who are eager to protect their future fertility. This is the first report on long-term FP outcomes in a single tertiary center in Korea. We expect that there will be more cases over the years and more women returning to use their gametes or embryos for pregnancy.https://www.frontiersin.org/articles/10.3389/fendo.2022.845051/fullembryo cyropreservationfertility preservationoncofertilityoocyte cryopreservationovarian tissue cryopreservation |
| spellingShingle | Yae Ji Choi Yae Ji Choi Yeon Hee Hong Yeon Hee Hong Seongbeen Kim Seul Ki Kim Seul Ki Kim Jung Ryeol Lee Jung Ryeol Lee Chang Suk Suh Chang Suk Suh The Experience of Fertility Preservation in a Single Tertiary Center in Korea Frontiers in Endocrinology embryo cyropreservation fertility preservation oncofertility oocyte cryopreservation ovarian tissue cryopreservation |
| title | The Experience of Fertility Preservation in a Single Tertiary Center in Korea |
| title_full | The Experience of Fertility Preservation in a Single Tertiary Center in Korea |
| title_fullStr | The Experience of Fertility Preservation in a Single Tertiary Center in Korea |
| title_full_unstemmed | The Experience of Fertility Preservation in a Single Tertiary Center in Korea |
| title_short | The Experience of Fertility Preservation in a Single Tertiary Center in Korea |
| title_sort | experience of fertility preservation in a single tertiary center in korea |
| topic | embryo cyropreservation fertility preservation oncofertility oocyte cryopreservation ovarian tissue cryopreservation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.845051/full |
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