The Protective Role of Ozone Therapy in Kidney Disease: A Review
Ozone (O<sub>3</sub>) is a reactive oxygen species (ROS) that can interact with cellular components and cause oxidative stress. Following said logic, if O<sub>3</sub> induces such a stressful milieu, how does it exert antioxidant functions? This is mediated by controlled toxi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/3/752 |
| _version_ | 1797610570363437056 |
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| author | Luis Fernando Delgadillo-Valero Estefani Yaquelin Hernández-Cruz José Pedraza-Chaverri |
| author_facet | Luis Fernando Delgadillo-Valero Estefani Yaquelin Hernández-Cruz José Pedraza-Chaverri |
| author_sort | Luis Fernando Delgadillo-Valero |
| collection | DOAJ |
| description | Ozone (O<sub>3</sub>) is a reactive oxygen species (ROS) that can interact with cellular components and cause oxidative stress. Following said logic, if O<sub>3</sub> induces such a stressful milieu, how does it exert antioxidant functions? This is mediated by controlled toxicity produced by low concentrations of O<sub>3</sub>, which enhance the cell’s suppliance of antioxidant properties without causing any further damage. Therapeutic concentrations vary extensively, although 50 µg/mL is commonly used in experimental and clinical procedures, given that augmented concentrations might work as germicides or cause endogenous damage. O<sub>3</sub> therapy has been shown to be effective when applied before or after traumatic renal procedures, whether caused by ischemia, xenobiotics, chronic damage, or other models. In this review, we focus on discussing the role of O<sub>3</sub> therapy in different models of kidney damage associated with fibrosis, apoptosis, oxidative stress, and inflammation. We integrate and report knowledge about O<sub>3</sub> in renal therapy, debunking skepticism towards unconventional medicine, explaining its proven therapeutic properties, and thus providing background for its use in further research as well as in clinical settings. |
| first_indexed | 2024-03-11T06:17:04Z |
| format | Article |
| id | doaj.art-3a2bd956656d4218b6199d55b6148138 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T06:17:04Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-3a2bd956656d4218b6199d55b61481382023-11-17T12:11:52ZengMDPI AGLife2075-17292023-03-0113375210.3390/life13030752The Protective Role of Ozone Therapy in Kidney Disease: A ReviewLuis Fernando Delgadillo-Valero0Estefani Yaquelin Hernández-Cruz1José Pedraza-Chaverri2Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04360, MexicoLaboratory F-315, Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City 04510, MexicoLaboratory F-315, Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City 04510, MexicoOzone (O<sub>3</sub>) is a reactive oxygen species (ROS) that can interact with cellular components and cause oxidative stress. Following said logic, if O<sub>3</sub> induces such a stressful milieu, how does it exert antioxidant functions? This is mediated by controlled toxicity produced by low concentrations of O<sub>3</sub>, which enhance the cell’s suppliance of antioxidant properties without causing any further damage. Therapeutic concentrations vary extensively, although 50 µg/mL is commonly used in experimental and clinical procedures, given that augmented concentrations might work as germicides or cause endogenous damage. O<sub>3</sub> therapy has been shown to be effective when applied before or after traumatic renal procedures, whether caused by ischemia, xenobiotics, chronic damage, or other models. In this review, we focus on discussing the role of O<sub>3</sub> therapy in different models of kidney damage associated with fibrosis, apoptosis, oxidative stress, and inflammation. We integrate and report knowledge about O<sub>3</sub> in renal therapy, debunking skepticism towards unconventional medicine, explaining its proven therapeutic properties, and thus providing background for its use in further research as well as in clinical settings.https://www.mdpi.com/2075-1729/13/3/752ozoneozone therapykidney diseaseoxidative stressantioxidants defenseinflammation |
| spellingShingle | Luis Fernando Delgadillo-Valero Estefani Yaquelin Hernández-Cruz José Pedraza-Chaverri The Protective Role of Ozone Therapy in Kidney Disease: A Review Life ozone ozone therapy kidney disease oxidative stress antioxidants defense inflammation |
| title | The Protective Role of Ozone Therapy in Kidney Disease: A Review |
| title_full | The Protective Role of Ozone Therapy in Kidney Disease: A Review |
| title_fullStr | The Protective Role of Ozone Therapy in Kidney Disease: A Review |
| title_full_unstemmed | The Protective Role of Ozone Therapy in Kidney Disease: A Review |
| title_short | The Protective Role of Ozone Therapy in Kidney Disease: A Review |
| title_sort | protective role of ozone therapy in kidney disease a review |
| topic | ozone ozone therapy kidney disease oxidative stress antioxidants defense inflammation |
| url | https://www.mdpi.com/2075-1729/13/3/752 |
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