Lactobacillus and Allobaculum mediates the improvement of vascular endothelial dysfunction during hypertension with TaohongSiwu decoction combined with Dubosiella newyorkensis
Background: Previous study confirmed that both TaohongSiwu decoction (THSWD) and Dubosiella newyorkensis improved hypertension-induced endothelial dysfunction. However, the mechanism of THSWD combined with Dubosiella newyorkensis remains unclear. Purpos: e: We aimed to investigate the microecologica...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023097803 |
| _version_ | 1797383993116590080 |
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| author | Tianhao Liu Xiaoya Li Chenyang Zhang Lin Zhao Xue Li Yusheng Yu Yahong Zhou Yuzheng Xue |
| author_facet | Tianhao Liu Xiaoya Li Chenyang Zhang Lin Zhao Xue Li Yusheng Yu Yahong Zhou Yuzheng Xue |
| author_sort | Tianhao Liu |
| collection | DOAJ |
| description | Background: Previous study confirmed that both TaohongSiwu decoction (THSWD) and Dubosiella newyorkensis improved hypertension-induced endothelial dysfunction. However, the mechanism of THSWD combined with Dubosiella newyorkensis remains unclear. Purpos: e: We aimed to investigate the microecological mechanism underlying the THSWD combined with Dubosiella newyorkensis for the prevention of hypertensive vascular endothelial dysfunction. Methods: Eight percent high-salt diet was applied to induce hypertension in a mouse model for 4 weeks. THSWD, Dubosiella newyorkensis and THSWD combined with Dubosiella newyorkensis were used to intervene in the model mice to observe the changes of systolic blood pressure (SBP), body weight, blood routine, endothelial function, gut contents microbiota and bile acid metabolites. Results: Results revealed that THSWD combined with Dubosiella newyorkensis significantly restored blood pressure and regulated body weight, and markedly downregulating serum and vascular levels of endothelin-1 (ET-1), thrombin regulatory protein (TM), vascular hemophilia factor (vWF) and vascular endothelial growth factor (VEGF), and upregulating nitric oxide (NO) levels compared with the model group. Notably, It altered the diversity and community structure of gut contents microbiota in mice. Lactobacillus and Allobaculum was enormously up-regulated at the genus level. Serum bile acid differential metabolites cholic acid and chenodeoxycholic acid were markedly altered. Futhermore, there was a close relationship between Lactobacillus, Allobaculum and endothelial function indexes in mice. Conclusion: Lactobacillus and Allobaculum play important roles in the prevention of vascular endothelial dysfunction in hypertension during the THSWD combined with Dubosiella newyorkensis. |
| first_indexed | 2024-03-08T21:29:01Z |
| format | Article |
| id | doaj.art-3a2caaa09312453a98cd587aea6a7a92 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T21:29:01Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-3a2caaa09312453a98cd587aea6a7a922023-12-21T07:33:51ZengElsevierHeliyon2405-84402023-12-01912e22572Lactobacillus and Allobaculum mediates the improvement of vascular endothelial dysfunction during hypertension with TaohongSiwu decoction combined with Dubosiella newyorkensisTianhao Liu0Xiaoya Li1Chenyang Zhang2Lin Zhao3Xue Li4Yusheng Yu5Yahong Zhou6Yuzheng Xue7Affiliated Hospital of Jiangnan University, Wuxi, China; College of Medicine, Jiangnan University, Wuxi, ChinaSchool of Basic Medical Science, Yunan University of Traditional Chinese Medicine, Kunming, ChinaAffiliated Hospital of Jiangnan University, Wuxi, ChinaCollege of Medicine, Jiangnan University, Wuxi, ChinaWuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, ChinaCollege of Medicine, Jiangnan University, Wuxi, ChinaWuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, China; Corresponding author.Affiliated Hospital of Jiangnan University, Wuxi, China; Corresponding author.Background: Previous study confirmed that both TaohongSiwu decoction (THSWD) and Dubosiella newyorkensis improved hypertension-induced endothelial dysfunction. However, the mechanism of THSWD combined with Dubosiella newyorkensis remains unclear. Purpos: e: We aimed to investigate the microecological mechanism underlying the THSWD combined with Dubosiella newyorkensis for the prevention of hypertensive vascular endothelial dysfunction. Methods: Eight percent high-salt diet was applied to induce hypertension in a mouse model for 4 weeks. THSWD, Dubosiella newyorkensis and THSWD combined with Dubosiella newyorkensis were used to intervene in the model mice to observe the changes of systolic blood pressure (SBP), body weight, blood routine, endothelial function, gut contents microbiota and bile acid metabolites. Results: Results revealed that THSWD combined with Dubosiella newyorkensis significantly restored blood pressure and regulated body weight, and markedly downregulating serum and vascular levels of endothelin-1 (ET-1), thrombin regulatory protein (TM), vascular hemophilia factor (vWF) and vascular endothelial growth factor (VEGF), and upregulating nitric oxide (NO) levels compared with the model group. Notably, It altered the diversity and community structure of gut contents microbiota in mice. Lactobacillus and Allobaculum was enormously up-regulated at the genus level. Serum bile acid differential metabolites cholic acid and chenodeoxycholic acid were markedly altered. Futhermore, there was a close relationship between Lactobacillus, Allobaculum and endothelial function indexes in mice. Conclusion: Lactobacillus and Allobaculum play important roles in the prevention of vascular endothelial dysfunction in hypertension during the THSWD combined with Dubosiella newyorkensis.http://www.sciencedirect.com/science/article/pii/S2405844023097803THSWDDubosiella newyorkensisHypertensionVascular endothelial dysfunctionMicroecological mechanism |
| spellingShingle | Tianhao Liu Xiaoya Li Chenyang Zhang Lin Zhao Xue Li Yusheng Yu Yahong Zhou Yuzheng Xue Lactobacillus and Allobaculum mediates the improvement of vascular endothelial dysfunction during hypertension with TaohongSiwu decoction combined with Dubosiella newyorkensis Heliyon THSWD Dubosiella newyorkensis Hypertension Vascular endothelial dysfunction Microecological mechanism |
| title | Lactobacillus and Allobaculum mediates the improvement of vascular endothelial dysfunction during hypertension with TaohongSiwu decoction combined with Dubosiella newyorkensis |
| title_full | Lactobacillus and Allobaculum mediates the improvement of vascular endothelial dysfunction during hypertension with TaohongSiwu decoction combined with Dubosiella newyorkensis |
| title_fullStr | Lactobacillus and Allobaculum mediates the improvement of vascular endothelial dysfunction during hypertension with TaohongSiwu decoction combined with Dubosiella newyorkensis |
| title_full_unstemmed | Lactobacillus and Allobaculum mediates the improvement of vascular endothelial dysfunction during hypertension with TaohongSiwu decoction combined with Dubosiella newyorkensis |
| title_short | Lactobacillus and Allobaculum mediates the improvement of vascular endothelial dysfunction during hypertension with TaohongSiwu decoction combined with Dubosiella newyorkensis |
| title_sort | lactobacillus and allobaculum mediates the improvement of vascular endothelial dysfunction during hypertension with taohongsiwu decoction combined with dubosiella newyorkensis |
| topic | THSWD Dubosiella newyorkensis Hypertension Vascular endothelial dysfunction Microecological mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023097803 |
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