The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson’s disease
Parkinson’s disease (PD) is an age-related chronic neurodegenerative disease caused by the death and degeneration of dopaminergic neurons in the substantia nigra of the midbrain. The decrease of the neurotransmitter dopamine in the patient’s brain leads to various motor symptoms. PD drugs mainly enh...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.963327/full |
| _version_ | 1797986444007964672 |
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| author | Changcheng Lu Shuhui Qu Zhangfeng Zhong Hua Luo Si San Lei Hai-Jing Zhong Huanxing Su Yitao Wang Cheong-Meng Chong |
| author_facet | Changcheng Lu Shuhui Qu Zhangfeng Zhong Hua Luo Si San Lei Hai-Jing Zhong Huanxing Su Yitao Wang Cheong-Meng Chong |
| author_sort | Changcheng Lu |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is an age-related chronic neurodegenerative disease caused by the death and degeneration of dopaminergic neurons in the substantia nigra of the midbrain. The decrease of the neurotransmitter dopamine in the patient’s brain leads to various motor symptoms. PD drugs mainly enhance dopamine levels but cannot prevent or slow down the loss of dopaminergic neurons. In addition, they exhibit significant side effects and addiction issues during long-term use. Therefore, it is particularly urgent to develop novel drugs that have fewer side effects, can improve PD symptoms, and prevent the death of dopaminergic neurons. The rhizome of Gastrodia elata Blume (Tianma) is a well-known medicinal herb and has long been used as a treatment of nervous system-related diseases in China. Several clinical studies showed that formula comprising Tianma could be used as an add-on therapy for PD patients. Pharmacological studies indicated that Tianma and its bioactive components can reduce the death of dopaminergic neurons, α-synuclein accumulation, and neuroinflammation in various PD models. In this review, we briefly summarize studies regarding the effects of Tianma and its bioactive components’ effects on major PD features and explore the potential use of Tianma components for the treatment of PD. |
| first_indexed | 2024-04-11T07:33:50Z |
| format | Article |
| id | doaj.art-3a2d21ae9c794d6ba3de119e21b0ac9d |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T07:33:50Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3a2d21ae9c794d6ba3de119e21b0ac9d2022-12-22T04:36:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.963327963327The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson’s diseaseChangcheng Lu0Shuhui Qu1Zhangfeng Zhong2Hua Luo3Si San Lei4Hai-Jing Zhong5Huanxing Su6Yitao Wang7Cheong-Meng Chong8tate Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, Chinatate Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, Chinatate Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, Chinatate Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, Chinatate Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, Chinanternational Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou, Chinatate Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, Chinaacau Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, Chinatate Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, ChinaParkinson’s disease (PD) is an age-related chronic neurodegenerative disease caused by the death and degeneration of dopaminergic neurons in the substantia nigra of the midbrain. The decrease of the neurotransmitter dopamine in the patient’s brain leads to various motor symptoms. PD drugs mainly enhance dopamine levels but cannot prevent or slow down the loss of dopaminergic neurons. In addition, they exhibit significant side effects and addiction issues during long-term use. Therefore, it is particularly urgent to develop novel drugs that have fewer side effects, can improve PD symptoms, and prevent the death of dopaminergic neurons. The rhizome of Gastrodia elata Blume (Tianma) is a well-known medicinal herb and has long been used as a treatment of nervous system-related diseases in China. Several clinical studies showed that formula comprising Tianma could be used as an add-on therapy for PD patients. Pharmacological studies indicated that Tianma and its bioactive components can reduce the death of dopaminergic neurons, α-synuclein accumulation, and neuroinflammation in various PD models. In this review, we briefly summarize studies regarding the effects of Tianma and its bioactive components’ effects on major PD features and explore the potential use of Tianma components for the treatment of PD.https://www.frontiersin.org/articles/10.3389/fphar.2022.963327/fullParkisnon’s diseasetianma (Gastrodia elata blume)dopaminergic neuronsneuroinflmamationsynuclein |
| spellingShingle | Changcheng Lu Shuhui Qu Zhangfeng Zhong Hua Luo Si San Lei Hai-Jing Zhong Huanxing Su Yitao Wang Cheong-Meng Chong The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson’s disease Frontiers in Pharmacology Parkisnon’s disease tianma (Gastrodia elata blume) dopaminergic neurons neuroinflmamation synuclein |
| title | The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson’s disease |
| title_full | The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson’s disease |
| title_fullStr | The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson’s disease |
| title_full_unstemmed | The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson’s disease |
| title_short | The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson’s disease |
| title_sort | effects of bioactive components from the rhizome of gastrodia elata blume tianma on the characteristics of parkinson s disease |
| topic | Parkisnon’s disease tianma (Gastrodia elata blume) dopaminergic neurons neuroinflmamation synuclein |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.963327/full |
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