Periodontal Disease and Neurodegeneration: The Possible Pathway and Contribution from Periodontal Infections
Neurodegeneration is a process in which the neurons lose its structure, function and ultimately the death of the neurons follows. Various neurodegenerative diseases like Alzheimer’s, Parkinson’s etc., are thus gaining enormous interest in health plans. Scientists are in search of finding the various...
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JCDR Research and Publications Private Limited
2018-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/11045/29110_CE(RA1)_F(AP)_PF1(SK_BT_AP)_PFA(AP)_PB(MJ_AP)_PN(AP).pdf |
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| author | Rajeev Ranjan Gyanaseni Dhar Swetapadma Sahu Nibedita Nayak Monalisa Mishra |
| author_facet | Rajeev Ranjan Gyanaseni Dhar Swetapadma Sahu Nibedita Nayak Monalisa Mishra |
| author_sort | Rajeev Ranjan |
| collection | DOAJ |
| description | Neurodegeneration is a process in which the neurons lose its structure, function and ultimately the death of the neurons follows. Various neurodegenerative diseases like Alzheimer’s, Parkinson’s etc., are thus gaining enormous interest in health plans. Scientists are in search of finding the various markers to detect the onset of neurodegeneration. So far, Amyloid-beta (Aβ) and neurofibrillary tangle are the two markers found in most neurodegenerative diseases. Besides that, neural inflammation is also considered as one of the parameters for the onset of neurodegeneration. Inflammation may be caused either by insult of central nervous system or by peripheral infections. Numerous microbes get a chance to enter into the brain due to bacterial infection especially periodontal infection. The current review summarises the role of periodontal infection and the mechanism via which it contributes for neurodegeneration. |
| first_indexed | 2024-12-10T16:21:38Z |
| format | Article |
| id | doaj.art-3a2ee7e78128449ba7b5c70e20cc7f84 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-10T16:21:38Z |
| publishDate | 2018-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-3a2ee7e78128449ba7b5c70e20cc7f842022-12-22T01:41:47ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-01-01121DE01DE0510.7860/JCDR/2018/29110.11045Periodontal Disease and Neurodegeneration: The Possible Pathway and Contribution from Periodontal InfectionsRajeev Ranjan0Gyanaseni Dhar1Swetapadma Sahu2Nibedita Nayak3Monalisa Mishra4Senior Lecturer, Department of Periodontics and Oral Implantology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology University, Bhubaneswar, Odisha, India.INSPIRE Fellow, Department of Life Science, National Institute of Technology, Rourkela, Odisha, India.INSPIRE Fellow, Department of Life Science, National Institute of Technology, Rourkela, Odisha, India.INSPIRE Fellow, Department of Life Science, National Institute of Technology, Rourkela, Odisha, India.Assistant Professor, Department of Life Science, National Institute of Technology, Rourkela, Odisha, India.Neurodegeneration is a process in which the neurons lose its structure, function and ultimately the death of the neurons follows. Various neurodegenerative diseases like Alzheimer’s, Parkinson’s etc., are thus gaining enormous interest in health plans. Scientists are in search of finding the various markers to detect the onset of neurodegeneration. So far, Amyloid-beta (Aβ) and neurofibrillary tangle are the two markers found in most neurodegenerative diseases. Besides that, neural inflammation is also considered as one of the parameters for the onset of neurodegeneration. Inflammation may be caused either by insult of central nervous system or by peripheral infections. Numerous microbes get a chance to enter into the brain due to bacterial infection especially periodontal infection. The current review summarises the role of periodontal infection and the mechanism via which it contributes for neurodegeneration.https://jcdr.net/articles/PDF/11045/29110_CE(RA1)_F(AP)_PF1(SK_BT_AP)_PFA(AP)_PB(MJ_AP)_PN(AP).pdfalzheimer diseaseamyloid-betagingivitis |
| spellingShingle | Rajeev Ranjan Gyanaseni Dhar Swetapadma Sahu Nibedita Nayak Monalisa Mishra Periodontal Disease and Neurodegeneration: The Possible Pathway and Contribution from Periodontal Infections Journal of Clinical and Diagnostic Research alzheimer disease amyloid-beta gingivitis |
| title | Periodontal Disease and Neurodegeneration: The Possible Pathway and Contribution from Periodontal Infections |
| title_full | Periodontal Disease and Neurodegeneration: The Possible Pathway and Contribution from Periodontal Infections |
| title_fullStr | Periodontal Disease and Neurodegeneration: The Possible Pathway and Contribution from Periodontal Infections |
| title_full_unstemmed | Periodontal Disease and Neurodegeneration: The Possible Pathway and Contribution from Periodontal Infections |
| title_short | Periodontal Disease and Neurodegeneration: The Possible Pathway and Contribution from Periodontal Infections |
| title_sort | periodontal disease and neurodegeneration the possible pathway and contribution from periodontal infections |
| topic | alzheimer disease amyloid-beta gingivitis |
| url | https://jcdr.net/articles/PDF/11045/29110_CE(RA1)_F(AP)_PF1(SK_BT_AP)_PFA(AP)_PB(MJ_AP)_PN(AP).pdf |
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