An integrated strategy by chemical characterization, in vivo metabolism, chemical isolation, and activity evaluation to target discovery of potential active substances in traditional Chinese medicine: Mori Fructus as an example

An integrated strategy by chemical characterization, in vivo metabolism, chemical isolation, and activity evaluation to target discovery of potential active substances in traditional Chinese medicine: Mori Fructus as an example

Mori Fructus (MF) is a famous edible fruit of Morus alba L. as well as traditional Chinese medicine (TCM). Moreover, exposure behavior of complex components in vivo is a necessary way to elucidate active substances in TCMs. However, the effective discovery of active ingredients from MF in vivo is st...

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Bibliographic Details
Main Authors: Xi-yang Tang, Peng-cheng Zhao, Ming-hao Chen, Xiao-xing Wang, Cai-lian Fan, Zhi-hong Yao, Xin-sheng Yao, Yi Dai
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Arabian Journal of Chemistry
Subjects:
Mori Fructus
In vivo metabolism
LC-MS guided isolation
Alkaloids
Lipid-lowering activity
PCSK9
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223003209

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