Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks
Long noncoding RNAs (lncRNAs) mediate important epigenetic regulation in a wide range of biological processes. However, the effect of all dysregulated lncRNAs in myocardial infarction (MI) is not clear. Whole transcriptome sequencing analysis was used to characterize the dynamic changes in lncRNA an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-03-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2023-0657 |
| _version_ | 1797848638239539200 |
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| author | Yang Jingqi Yang Ming Sheng Guotai |
| author_facet | Yang Jingqi Yang Ming Sheng Guotai |
| author_sort | Yang Jingqi |
| collection | DOAJ |
| description | Long noncoding RNAs (lncRNAs) mediate important epigenetic regulation in a wide range of biological processes. However, the effect of all dysregulated lncRNAs in myocardial infarction (MI) is not clear. Whole transcriptome sequencing analysis was used to characterize the dynamic changes in lncRNA and mRNA expression. A gene network was constructed, and genes were classified into different modules using WGCNA. In addition, for all dysregulated lncRNAs, gene ontology analysis and cis-regulatory analysis were applied. The results demonstrated that a large number of the differentially co-expressed genes were primarily linked to the immune system process, inflammatory response, and innate immune response. The functional pathway analysis of the MEblue module included immune system process and apoptosis, and MEbrown included the T-cell receptor signal pathway by WGCNA. In addition, through cis-acting analysis of lncRNA regulation, the cis-regulated mRNAs were mainly enriched in immune system processes, innate immune responses, and VEGF signal pathways. We found that lncRNA regulation of mRNAs plays an important role in immune and inflammatory pathways. Our study provides a foundation to further understand the role and potential mechanism of dysregulated lncRNAs in the regulation of MI, in which many of them could be potential targets for MI. |
| first_indexed | 2024-04-09T18:31:46Z |
| format | Article |
| id | doaj.art-3a32e766a93b49bf8c542cf1ca860df7 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-09T18:31:46Z |
| publishDate | 2023-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-3a32e766a93b49bf8c542cf1ca860df72023-04-11T17:07:17ZengDe GruyterOpen Medicine2391-54632023-03-0118157687510.1515/med-2023-0657Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networksYang Jingqi0Yang Ming1Sheng Guotai2Department of Cardiovascular Medicine, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330000, ChinaDepartment of Cardiovascular Medicine, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330000, ChinaDepartment of Cardiovascular Medicine, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330000, ChinaLong noncoding RNAs (lncRNAs) mediate important epigenetic regulation in a wide range of biological processes. However, the effect of all dysregulated lncRNAs in myocardial infarction (MI) is not clear. Whole transcriptome sequencing analysis was used to characterize the dynamic changes in lncRNA and mRNA expression. A gene network was constructed, and genes were classified into different modules using WGCNA. In addition, for all dysregulated lncRNAs, gene ontology analysis and cis-regulatory analysis were applied. The results demonstrated that a large number of the differentially co-expressed genes were primarily linked to the immune system process, inflammatory response, and innate immune response. The functional pathway analysis of the MEblue module included immune system process and apoptosis, and MEbrown included the T-cell receptor signal pathway by WGCNA. In addition, through cis-acting analysis of lncRNA regulation, the cis-regulated mRNAs were mainly enriched in immune system processes, innate immune responses, and VEGF signal pathways. We found that lncRNA regulation of mRNAs plays an important role in immune and inflammatory pathways. Our study provides a foundation to further understand the role and potential mechanism of dysregulated lncRNAs in the regulation of MI, in which many of them could be potential targets for MI.https://doi.org/10.1515/med-2023-0657long noncoding rnamyocardial infarctionimmune systeminflammationregulatory networks |
| spellingShingle | Yang Jingqi Yang Ming Sheng Guotai Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks Open Medicine long noncoding rna myocardial infarction immune system inflammation regulatory networks |
| title | Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks |
| title_full | Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks |
| title_fullStr | Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks |
| title_full_unstemmed | Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks |
| title_short | Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks |
| title_sort | dysregulated lncrnas are involved in the progress of myocardial infarction by constructing regulatory networks |
| topic | long noncoding rna myocardial infarction immune system inflammation regulatory networks |
| url | https://doi.org/10.1515/med-2023-0657 |
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